Pediatric Preclinical Testing Consortium: Coordinating Center-Additional PPTC funding extension

儿科临床前检测联盟：协调中心-额外PPTC资金延期

• 批准号: 10302652
• 负责人: GREGORY J GATTO
• 金额: $ 25.15万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-11-14 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10302652
• 关键词: Adult; Antineoplastic Agents; Childhood; Childhood Cancer Treatment; Clinical Trials; Collaborations; Community Clinical Oncology Program; Data; Data Collection; Data Management Resources; Development; Elements; Ensure; Funding; Goals; Human; Investments; Leadership; Logistics; Malignant Childhood Neoplasm; Malignant Neoplasms; Mission; Modeling; Molecular Target; Output; Pediatric Oncology; Pharmaceutical Preparations; Pharmacologic Substance; Pre-Clinical Model; Preclinical Testing; Procedures; Process; Program Evaluation; Research; Resources; Running; Scientist; Side; Statistical Data Interpretation; Teleconferences; Testing; Therapeutic Agents; Translating; advocacy organizations; clinical development; clinical practice; data dictionary; data management; drug candidate; effective therapy; flexibility; innovation; meetings; member; novel; novel therapeutics; pre-clinical; programs; success; tool; web site; webinar; Adult; Antineoplastic Agents; Childhood; Childhood Cancer Treatment; Clinical Trials; Collaborations; Community Clinical Oncology Program; Data; Data Collection; Data Management Resources; Development; Elements; Ensure; Funding; Goals; Human; Investments; Leadership; Logistics; Malignant Childhood Neoplasm; Malignant Neoplasms; Mission; Modeling; Molecular Target; Output; Pediatric Oncology; Pharmaceutical Preparations; Pharmacologic Substance; Pre-Clinical Model; Preclinical Testing; Procedures; Process; Program Evaluation; Research; Resources; Running; Scientist; Side; Statistical Data Interpretation; Teleconferences; Testing; Therapeutic Agents; Translating; advocacy organizations; clinical development; clinical practice; data dictionary; data management; drug candidate; effective therapy; flexibility; innovation; meetings; member; novel; novel therapeutics; pre-clinical; programs; success; tool; web site; webinar

Project Summary The main goal of the Pediatric Preclinical Testing Consortium (PPTC) is to develop models that will translate to human clinical practice and effectively prioritize therapies for the treatment of pediatric cancers. An effective Coordinating Center (CC) will be critical to the Consortium’s goals by providing broad organizational, scientific, and analytic expertise to support NCI scientists and the PPTC Research Programs. The CC will also be responsible for developing, implementing, and evaluating a comprehensive PPTC research program, providing leadership in data collection and ongoing program evaluation to ensure that the research program is making optimal progress toward the PPTC mission. Providing the organizational and administrative leadership necessary to enable the Consortium to function efficiently will also be a key function of the CC. RTI’s goal as the proposed CC for the PPTC will be to optimize Consortium progress in generating reliable data to accelerate the development of more effective treatments for children with cancer by achieving the following specific aims: 1. Guide interactions between Consortium members and the pediatric oncology community. Provide the logistical support necessary to run an efficient and productive Consortium through effective teleconferences, webinars, Consortium meetings, and website. Employ these tools to facilitate interactions between PPTC members, pharmaceutical companies, and pediatric oncology advocacy organizations to ensure that promising new therapies are utilized efficiently. 2. Generate reliable predictive data that can be used for prioritization of therapeutic agents in pediatric cancer. Provide efficient and robust procedures for data collection, and statistical analysis of data collected from the Research Programs. 3. Provide the Consortium with a comprehensive, yet flexible set of scientific, statistical, and analytic resources needed to develop an innovative research program for creating a functional Consortium for pediatric preclinical testing. Develop tools to track the status of each potential drug candidate through the preclinical process. Document variables in a Consortium-side data dictionary as one element to build the data management system in REDCap.

项目摘要 小儿临床前测试联盟（PPTC）的主要目标是开发模型 转化为人类临床实践，并有效地优先考虑治疗小儿的治疗方法 癌症。有效的协调中心（CC）将通过提供对财团的目标至关重要 广泛的组织，科学和分析专业知识，以支持NCI科学家和PPTC研究 程序。 CC还将负责开发，实施和评估 全面的PPTC研究计划，在数据收集和正在进行的计划中提供领导 评估以确保研究计划在PPTC任务中取得最佳进步。 提供必要的组织和行政领导，使财团能够 功能有效也将是CC的关键功能。 RTI作为PPTC提议的CC的目标将 要优化联盟的进度，以生成可靠的数据，以加速更多 通过实现以下特定目的对癌症儿童的有效治疗： 1。指导财团成员与儿科肿瘤学社区之间的相互作用。提供 通过有效运行高效和产品联盟所必需的后勤支持 电信，网络研讨会，财团会议和网站。采用这些工具来促进 PPTC成员，制药公司和儿科肿瘤学倡导之间的互动 组织有望有效利用新疗法的组织。 2。生成可靠的预测数据，可用于优先考虑儿科治疗剂 癌症。为数据收集提供高效且可靠的程序，并对数据进行统计分析 从研究计划中收集。 3。为财团提供一套全面但灵活的科学，统计和分析 开发创新研究计划所需的资源，以创建一个功能联盟 小儿临床前测试。开发通过通过 临床前过程。财团端数据字典中的文档变量是要构建的一个元素 REDCAP中的数据管理系统。