Functional Analysis of Sleep Promoting Neurons in Health and Disease

睡眠促进神经元在健康和疾病中的功能分析

• 批准号: 9302571
• 负责人: PAUL J SHAW
• 金额: $ 35.48万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9302571
• 关键词: ATP Receptors; Air; Alzheimer' s Disease; Alzheimer' s disease model; Animals; Architecture; Arousal; Attention; Awareness; Behavior; Behavioral; Brain; Brain imaging; Calcium; Cells; Characteristics; Cognition; Cognitive; Complex; Cyclic AMP; Data; Dependence; Disease; Dorsal; Drosophila genus; Equilibrium; Goals; Health; Human; Human Amyloid Precursor Protein; Impaired cognition; Individual; Learning; Light; Link; Memory; Mind; Monitor; Neurologic; Neurons; Peptides; Phenotype; Physiological; Physiology; Population; Process; Property; Proteins; Risk; Role; S-nitro-N-acetylpenicillamine; Signal Transduction; Sleep; Sleep Deprivation; Structure; Synapses; System; Testing; Time; Walking; Work; base; beta secretase; beta-site APP cleaving enzyme 1; cognitive function; cognitive process; connectome; experimental study; fly; interest; memory consolidation; nervous system disorder; neural circuit; optogenetics; relating to nervous system; response; selective attention; sensor; tau Proteins; tool; vesicle-associated membrane protein; virtual reality

Sleep, selective-attention and memory consolidation are adversely impacted by many, if not most, neurological conditions. Interestingly, recent studies suggest that neuronal activity during waking may alter the risk for developing Alzheimer's disease. With this in mind, we have identified a genetically-tractable neural circuit that is impacted by Alzheimer's disease and is also uniquely suited for dissecting the dynamic, bi-directional relationship between sleep and cognition. That is, we are less interested in defining a minimal set of neurons that control a behavior than we are in understanding how these neurons interact (e.g., via a sleep- cognitive connectome). In this proposal we will investigate how connected structures in the fly brain work together to regulate sleep and cognition during health and in the context of Alzheimer's disease. Since we have recently demonstrated that the power of sleep can be harnessed to reverse cognitive impairments in a Drosophila model of Alzheimer's disease, a goal of this proposal will be to define the functional properties of circuits that confer the benefits of sleep to cognitive processes.

睡眠，选择性注意力和记忆巩固受到许多（如果没有）的不利影响 大多数是神经系统条件。有趣的是，最近的研究表明神经元活动 在醒来时，可能会改变患阿尔茨海默氏病的风险。考虑到这一点，我们 已经确定了受阿尔茨海默氏病影响的遗传学神经回路 并且也非常适合剖析动态的双向关系 睡眠和认知。也就是说，我们对定义最小的神经元的感兴趣 控制行为比我们了解这些神经元如何相互作用（例如，通过睡眠 - 认知连接组）。在此提案中，我们将研究如何即时建筑物 大脑一起工作以调节健康期间的睡眠和认知 阿尔茨海默氏病。由于我们最近证明睡眠的力量可以是 在阿尔茨海默氏病的果蝇模型中逆转认知障碍， 该提案的目标是定义赋予电路的功能特性 睡眠对认知过程的好处。