CVD in American Indians Study and Data Management Center and OK Field Center

美洲印第安人的CVD研究和数据管理中心和OK现场中心

基本信息

批准号：
9274844
负责人：
Julie A Stoner
金额：
$ 89.76万
依托单位：
UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-06-01 至 2019-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9274844
关键词：
Abdomen Accelerometer Address Adipose tissue Adult Affect Age Alcohols Alleles American Indians Architecture Atrial Fibrillation Behavioral Biological Biological Markers Blood Pressure Caliber Cardiac Cardiovascular Diseases Cardiovascular Physiology Cardiovascular system Clinical Cohort Studies Coupled Data Deposition Diabetes Mellitus Diet Disease Drug or chemical Tissue Distribution Elderly Environmental Exposure Epidemic Etiology Event Extended Family Family Family Study Fatty acid glycerol esters Foundations Functional disorder Gene Expression Genes Genetic Genetic Determinism Genetic Transcription Genetic Variation Genomics Health Heart Heart failure Hepatic Individual Inflammation Insulin Resistance Investigation Kidney Diseases Knowledge Lead Life Expectancy Link Liver Magnetic Resonance Imaging Measurement Measures Mental Health Metabolic Morbidity - disease rate Myocardial Infarction Nonesterified Fatty Acids Obesity Participant Persons Phenotype Physical activity Physiological Placebo Effect Plant Roots Population Prevention therapy Process RNA Recurrence Reproductive History Resources Risk Factors Role Socioeconomic Status Solid Statistical Data Interpretation Stroke Techniques Technology Tobacco use Triglycerides Variant abdominal fat aged base behavior measurement cardiovascular disorder risk clinical practice cohort data management demographics design diabetes risk diabetic diabetic cardiomyopathy experience follow-up genetic analysis genetic variant health disparity heart rate variability inflammatory marker innovation insight interest member middle age mortality novel obesity risk phenotypic data pre-clinical prediction algorithm public health relevance surveillance data tonometry transcriptomics trend

项目摘要

DESCRIPTION (provided by applicant): The Strong Heart Study (SHS) of two unique American Indian (AI) cohorts (4549 adults, aged 45 to 74 and 3838 ¿15 yrs. from 94 families) constitutes an unequalled and irreplaceable national resource. The proposed studies will elucidate the genetics and early pathophysiology of diabetic CVD and also address health disparities experienced by populations with high rates of diabetes and CVD. Very high rates of obesity and diabetes, especially among younger SHS participants, herald a pending epidemic of CVD, making them the ideal population in which to examine these processes. Measures of CVD, preclinical CVD, biomarkers, and genetic findings have provided valuable pathogenetic insights related to the etiology of CVD; the proposed investigations will take maximal advantage of this solid foundation and add innovative new measures. Our Aims: The identification of genetic variants affecting risk of obesity, diabetes, preclinical CVD, and CVD events, aided by new genomic technologies. We will use genomics techniques for SNP discovery and subsequent statistical analysis of functionality in regions known to contain genes of interest. Transcriptional profiling of RNA concurrent with a liver/abdominal MRI will be used to relate expression of genes and gene networks to CVD etiology. New biological measurements during a re-examination of the large family-based cohort will expand knowledge of pre-clinical stages of obesity and diabetes associated CVD. Novel phenotypes defined by MRI of the abdomen (for fat deposition in liver and adipose depots) will elucidate the etiology of preclinical disease in younger persons. Measures of central blood pressure (by applanation tonometry), heart rate variability and abdominal aortic size will broaden our understanding of CVD in association with obesity and diabetes. Measures of physiologic and behavioral risk factors, such as demographics, reproductive history, socioeconomic status, tobacco use, alcohol, diet, mental health indicators, and physical activity (by accelerometer) will add additional key phenotypes. Continuing mortality and morbidity surveillance of these cohorts will provide increased power in understanding how obesity and diabetes lead to strokes and heart failure in later life. Secular trends, life expectancy, the effects of renal disease on preclinical CVD, and the role of preclinical measures in predicting CVD endpoints will be explored. Thus, the proposed investigations will lead to new understanding of CVD and preclinical and diabetic CVD as well as improvements in clinical practice.

描述（由申请人提供）：两个独特的美洲印第安人 (AI) 群体（来自 94 个家庭的 4549 名 45 至 74 岁成年人和 3838 岁 15 岁）的强心脏研究 (SHS) 构成了拟议的无与伦比的、不可替代的国家资源。研究将阐明糖尿病心血管疾病的遗传学和早期病理生理学，并解决糖尿病发病率高的人群所经历的健康差异肥胖和糖尿病的发病率非常高，特别是在年轻的 SHS 参与者中，预示着 CVD 的流行，使他们成为检查这些过程、临床前 CVD、生物标志物和遗传发现的理想人群。提供了与 CVD 病因学相关的有价值的发病机制；拟议的研究将最大限度地利用这一坚实的基础，并增加创新的新措施：识别影响肥胖、糖尿病、临床前 CVD 风险的遗传变异。在新的基因组技术的帮助下，我们将使用基因组学技术来发现 SNP，并随后对已知包含感兴趣基因的区域进行功能统计分析，同时进行肝脏/腹部 MRI 的 RNA 转录分析，以进行相关表达。重新检查大型家庭队列期间的新生物学测量将扩大对肥胖和糖尿病相关 CVD 的临床前阶段的了解。腹部（肝脏和脂肪库中的脂肪沉积）将阐明年轻人临床前疾病的病因。中心血压（通过压平眼压测量）、心率变异性和腹主动脉大小的测量将拓宽我们对与肥胖相关的心血管疾病的理解。生理和行为风险因素的测量，例如人口统计、生育史、社会经济状况、吸烟、饮酒、饮食、心理健康指标和体力活动（通过额外的加速度计）。对这些人群的持续死亡率和发病率监测将为了解肥胖和糖尿病如何导致晚年中风和心力衰竭提供更多依据。因此，将探索预测 CVD 终点的临床前措施，因此，拟议的研究将导致对 CVD 和临床前和糖尿病 CVD 的新认识以及临床实践的改进。