FIBER OPTIC RAMAN IMAGER FOR VISUALIZING DENTAL CARIES

用于可视化龋齿的光纤拉曼成像仪

• 批准号: 9442785
• 负责人: Shan Yang
• 金额: $ 13.32万
• 依托单位: JACKSON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-03-01 至 2020-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9442785
• 关键词: Acids; Area; Benchmarking; Clinical; Collection; Complex; Computer software; Custom; Data; Dental; Dental Care; Dental Clinics; Dental Enamel; Dental Implants; Dental caries; Dental crowns; Dentin; Detection; Devices; Diagnosis; Diagnostic; Diagnostic Sensitivity; Disease Progression; Early Diagnosis; Feasibility Studies; Fiber Optics; Gold; Hand; Head; Histology; Image; Imaging Device; Individual; Intervention; Lasers; Lesion; Life; Light; Location; Measurable; Microscope; Minerals; Modality; Optics; Oral; Oral cavity; Oral health; Outcome; Patients; Penetration; Performance; Photons; Pilot Projects; Population; Positioning Attribute; Process; Roentgen Rays; Sampling; Scanning; Sensitivity and Specificity; Severities; Signal Transduction; Speed; Spottings; Surveys; System; Tactile; Technology; Testing; Time; Tooth Loss; Tooth structure; Treatment Cost; Visual; White Spots; base; care costs; clinical application; commercialization; cost; demineralization; early onset; imager; imaging study; imaging system; improved; in vivo; innovation; lens; mineralization; new technology; portability; remineralization; repaired; screening; sound; success; tool; tooth surface

Summary Dental caries is the most significant problem in oral health area. Early detection of caries is highly desired because decays can be reversed by remineralization. When detected later, caries result in costly treatments such as fillings, bridge, crown or dental implants, amounting to thousands of dollars per tooth. Therefore, the reliable diagnosis of decay at the early onset would have a significant impact by curbing the progression of the disease before the advanced stage of tooth decay and, in turn, alleviate the associated dental-care costs. Because early onset lesions are elusive to current technologies, there is great emphasis on developing new technologies for early diagnosis of caries. Raman imaging is promising but it needs to be lower cost and customized for the dental operatory. Raman can detect caries by visualizing changes in the mineralization of decaying enamel. The speed of existing Raman modalities (point by point scan etc.) does not allow a systematic survey of the oral space, and the Raman microscopes are too bulky and complex to be used in the dental operatory. A fiber optic Raman- imaging tool is essential to enable clinical utilization of Raman. The major aim of the proposed pilot study is to develop a Raman imaging device for early detection of caries. Aim 1 will integrate a hand- held fiber optic Raman imager for dental diagnostics. This imager is a portable and automated platform that is an innovative combination of microarray based wide-field excitation and 2D- signal collection optics to generate mineralization distributions of the occlusal, frontal and posterior aspects of the teeth. The system will generate full-field images of teeth surface finding lesions as least 100 µm size in the oral space within 5 minutes. Aim 2 will validate and refine the performance of the imager towards the detection of caries. The limits of detection (size of the lesion and the degree of mineralization) of the system will be assessed and improved by artificially induced lesions of controlled size and severity. The imager will then be tested blindly on sound teeth samples and those with naturally occurring caries lesions to determine its sensitivity and specificity against the gold standard undemineralized histology.

概括 龋齿是口腔健康领域最重要的问题，迫切需要早期发现龋齿。 因为当后来发现龋齿时，可以通过再矿化来逆转龋齿，从而导致昂贵的治疗费用。 如补牙、牙桥、牙冠或种植牙，每颗牙齿价值数千美元，因此值得信赖。 在发病早期诊断腐烂将对遏制疾病的进展产生重大影响 在蛀牙晚期之前，进而减轻相关的牙科护理费用。 目前的技术难以捕捉到发病病变，因此非常重视开发早期病变的新技术 拉曼成像的诊断前景广阔，但需要降低成本并针对牙科进行定制。 拉曼可以通过观察腐烂牙釉质的矿化速度的变化来检测龋齿。 现有拉曼模式（逐点扫描等）不允许对口腔空间进行系统调查，并且 拉曼显微镜体积太大且复杂，无法在牙科手术中使用。 成像工具对于拉曼的临床应用至关重要。拟议试点研究的主要目标。 Aim 1 将开发一种用于早期龋齿检测的拉曼成像设备。 用于牙科诊断的光纤拉曼成像仪 该成像仪是一个便携式自动化平台。 这是基于微阵列的宽场激发和 2D 信号收集光学器件的创新组合， 系统将生成牙齿咬合面、前牙面和后牙面的矿化分布。 生成牙齿表面的全视野图像，在 5 分钟内发现口腔空间中至少 100 µm 大小的病变。 目标 2 将验证和改进成像仪在龋齿检测方面的性能。 将评估系统的检测极限（病变大小和矿化程度）并 然后通过人工诱导的受控大小和严重程度的损伤来改善成像仪的情况。 健全的牙齿样本和那些自然发生的龋齿病变决定了其敏感性和特异性 反对未脱矿组织学的金标准。