FASEB SRC on Lipid Droplets on the Move from Health to Disease

FASEB SRC 关于脂滴从健康到疾病的转变

基本信息

批准号：
9543174
负责人：
PERRY E BICKEL
金额：
$ 1.5万
依托单位：
FEDERATION OF AMER SOC FOR EXPER BIOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-04-01 至 2019-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9543174
关键词：
Address Atherosclerosis Biochemical Biochemistry Biogenesis Biological Models Biology Biophysics Cardiovascular Diseases Cells Cellular biology Characteristics Clinical Research Collaborations Colorado Cultured Cells Development Diabetes Mellitus Disabled Persons Disease Drosophila genus Educational workshop Endocrinology Energy Metabolism Epidemic Equilibrium Feedback Fostering Functional disorder Funding Genetic Genetic Determinism Grant Health Human Imaging technology Immunity Insulin Resistance International Lipid Inclusion Lipids Lipodystrophy Lipolysis Malignant Neoplasms Medicine Metabolic Diseases Metabolic syndrome Metabolism Minority Modeling Movement Mus National Institute of Diabetes and Digestive and Kidney Diseases Nerve Degeneration Neurodegenerative Disorders Non-Insulin-Dependent Diabetes Mellitus Obesity Oral Organ Organelles Participant Pathology Physiology Play Postdoctoral Fellow Prevalence Prevention strategy Process Request for Applications Research Research Personnel Resort Scientist Site Students Time Tissues Training Underrepresented Minority United States National Institutes of Health Woman Work Writing Yeasts biophysical properties career collaborative environment design experience fly graduate student innovation insight meetings microscopic imaging next generation non-alcoholic fatty liver disease novel novel therapeutic intervention oxidation posters programs student training summer research symposium trafficking tumor metabolism

项目摘要

Project Summary The 6th FASEB Summer Research Conference on Lipid Droplets, entitled “Lipid Droplets on the Move from Health to Disease,” will focus on the rapidly developing field of lipid droplet biology. Lipid droplets are dynamic cellular organelles that play key roles in energy metabolism. Lipid droplet accumulation and dysfunction are hallmarks of metabolic diseases, including obesity, lipodystrophy, insulin resistance, diabetes, nonalcoholic fatty liver disease, and cardiovascular disease. Lipid droplets are increasingly being studied in the contexts of cancer metabolism, neurodegeneration and immunity as well. The increasing prevalence of metabolic disorders throughout the world lends increased urgency to encouraging research into fundamental aspects of how lipid droplets form, grow, move, mature, and degrade and how lipid droplets influence cell, tissue and organismal physiology and contribute to disease. Understanding of these concepts is necessary for the rationale design appropriate new therapeutic strategies. The conference will be held from June 24-29, 2018 at the Steamboat Grand Resort in Steamboat Springs, CO. The format includes an opening night keynote address by Lewis Cantley, eight sessions of talks by invited speakers, as well as short talks by trainees and early career investigators selected from submitted abstracts, four poster sessions, a Career Workshop on career design and balance, and a Meet the Experts session on advanced imaging microscopy. The meeting format will encourage and facilitate interactions between trainees, early career investigators and established investigators. The scientific sessions cover the full breadth of lipid-droplet biology, from biophysical, biochemical, and cellular topics to physiology and disease. Talks from internationally renowned researchers will span basic to clinical research and describe diverse approaches (biophysics, genetics, biochemistry, cell biology, physiology) and models (mice, humans, cultured cells, flies, yeast). This meeting continues to represent THE major international meeting dedicated exclusively to lipid droplets and remains a unique forum for researchers to exchange ideas and share breaking results in this dynamic and timely field. A central aim of this conference is training and encouraging the next generation of scientists. This application requests funding to support the participation of 14 graduate students, postdoctoral fellows and early career investigators, including women, underrepresented minorities, and persons with disabilities, who will be chosen from submitted abstracts judged as superior. The intimate conference format, the secluded conference site, and the many opportunities for informal interactions between participants, planned and unplanned, will provide young investigators opportunities to present their work, to obtain feedback from leaders in the field, and to get career advice.

项目摘要第六届Faseb夏季研究会议关于脂质液滴的研究会议，题为“从健康与疾病，“将重点放在脂质滴滴液滴生物学的快速发展领域。脂质液滴是动态的在能量代谢中起关键作用的细胞细胞器。代谢疾病的标志，包括肥胖，脂肪营养不良，胰岛素抵抗，糖尿病，非酒精性脂肪肝病和心血管疾病。癌症代谢，神经退行性和免疫力也增加了代谢的患病率全世界的疾病借出了迫切的紧迫性，以鼓励研究基本方面的研究脂质液滴如何形成，生长，移动，成熟和降解以及脂质滴滴降低影响细胞，组织和有机生理学并有助于疾病。 Raationale设计适当的新治疗策略。在Co. Steamboat Springs的Steamboat Grand Resort。该格式包括开幕式主题演讲刘易斯·坎特利（Lewis Cantley）的讲话，八次邀请发言人的会谈以及培训和早期职业调查人员从提交的摘要，四个海报会议，职业讲习班中选出职业设计和平衡，以及会议的专家会议格式将鼓励和促进互动研究人员。生理学和疾病的生化和细胞主题。将跨越临床研究并描述多种方法（生物物理学，遗传学，生物化学，细胞生物学，生理学）和模型（小鼠，人类，培养的细胞，苍蝇，Youst）。代表专门用于脂质液滴的主要国际会议，仍然是Aunique论坛研究人员在这个动态和及时的领域中交换想法并分享打破的结果。这次会议是培训并鼓励下一代科学。为了支持14名研究生，博士后研究员和早期职业调查员的参与，包括妇女，少数群体和残疾人，他们将从提交的摘要被认为是私密的会议格式，僻静的会议网站和你计划和计划外的参与者之间互动的许多机会将为年轻人提供调查人员有机会介绍他们的工作，从该领域的领导人那里获得反馈并获得职业建议。