Interdisciplinary Study of Two Novel Anticonvulsants in Alcoholism

两种新型抗惊厥药治疗酒精中毒的跨学科研究

• 批准号: 9353265
• 负责人: David H. Barlow
• 金额: $ 76.9万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-01-10 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9353265
• 关键词: Abstinence; Alcohol consumption; Alcoholism; Alcohols; Anticonvulsants; Area; Attenuated; Behavior; Brain; Centers for Disease Control and Prevention (U.S.); Cessation of life; Chronic; Clinical; Cues; Dopamine; Double-Blind Method; Effectiveness; Emotional; Emotions; Ethanol; Functional Magnetic Resonance Imaging; Funding; Image; Impairment; Impulsivity; Individual; Interdisciplinary Study; Lead; Measures; Mediating; Methods; Midbrain structure; Mission; Modeling; National Institute on Alcohol Abuse and Alcoholism; Neurobiology; Parietal; Performance; Pharmaceutical Preparations; Placebos; Process; Public Health; Research; Rewards; Risk; Risk-Taking; Stimulus; Testing; Therapeutic Effect; Ventral Striatum; alcohol cue; alcohol effect; alcohol exposure; alcohol relapse; alcohol response; alcohol reward; alcoholism therapy; analog; blood oxygenation level dependent response; craving; cue reactivity; drinking; genetic profiling; improved; neural circuit; neurobehavioral; novel; performance tests; placebo controlled study; predicting response; public health relevance; response; screening; tool; topiramate

 DESCRIPTION (provided by applicant): In a recent double-blind placebo-controlled study we found the broad spectrum anticonvulsant zonisamide (ZON) to have effects on ethanol consumption that are comparable to those of topiramate. We hypothesize here that the administration of ZON, by attenuating the hyperexcitability of the brain during periods of abstinence, through its neuro-protective effects, and its enhancement of dopamine activity in midbrain and frontal regions will counteract the effects of alcohol that lead to impaired regulatio of emotional and reward processes that control the consumption of alcohol. This will be evident by the normalization of brain activity seen in performance of the alcohol and emotional-word Stroop tasks and in a reduction of the BOLD response to alcohol related images. The results of this study should provide an indication of the neurobehavioral mechanisms through which ZON may act to regulate the consumption of alcohol.

 描述（由申请人提供）：在最近的一项双盲安慰剂对照研究中，我们发现广谱抗惊厥药唑尼沙胺 (ZON) 对乙醇消耗的影响与托吡酯相当。通过减弱禁欲期间大脑的过度兴奋，通过其神经保护作用，以及增强中脑和额叶区域的多巴胺活性，可以抵消这种影响酒精导致控制饮酒的情绪和奖励过程的调节受损，这可以通过执行酒精和情绪词斯特鲁普任务以及对大胆反应的减少中看到的大脑活动正常化来证明。与酒精相关的图像。这项研究的结果应该提供 ZON 可能调节酒精消耗的神经行为机制的指示。