Mentoring in Patient Oriented Research on Asthma and the Indoor Environment

指导以患者为中心的哮喘和室内环境研究

• 批准号: 9203614
• 负责人: Elizabeth C. Matsui
• 金额: $ 18.32万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-02-01 至 2020-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9203614
• 关键词: Affect; Allergens; Allergic; Allergic Disease; Asthma; Child; Childhood; Communities; Complex; Data; Decontamination; Development; Doctor of Philosophy; Eczema; Enrollment; Environment; Environmental Exposure; Environmental Health; Environmental Pollution; Epidemiologist; Evaluation; Exposure to; Funding; Genus staphylococcus; Goals; Gram-Positive Bacteria; Health; High Prevalence; Home environment; House Dust; Household; IgE; Immune response; Immunologist; Indoor environment; Inflammatory; Learning; Link; Lung diseases; Measures; Mentors; Mentorship; Methods; Microbe; Midcareer Investigator Award in Patient-Oriented Research; Morbidity - disease rate; Mus; Nose; Outcome; Pathway interactions; Pediatrics; Population; Prevention strategy; Proteins; Public Health; Pulmonary Inflammation; Recovery; Research; Research Project Grants; Respiratory physiology; Rodent; Role; Scientist; Source; Staphylococcal enterotoxin A; Staphylococcus aureus; Superantigens; Symptoms; Testing; Time; Training; career; chronic rhinosinusitis; environmental allergen; environmental allergy; genome sequencing; household environmental exposure; indoor exposure; inner city; insight; investigator training; microbial; mid-career faculty; patient oriented research; pollutant; polyposis; prevent; programs; public health intervention; public health relevance; remediation; research and development; skill acquisition; skills; staphylococcal enterotoxin; urban children; virtual; whole genome

DESCRIPTION (provided by applicant): The candidate is currently an Associate Professor of Pediatrics at Johns Hopkins and a pediatric allergist/immunologist, epidemiologist, and environmental health scientist whose broad career goal is to develop an understanding of the effects of the environment on asthma that results in feasible and actionable public health interventions to prevent asthma and reduce asthma morbidity. As the complex interplay between microbes, allergens, and pollutants must be understood in order to make significant progress in environmental control strategies for prevention and treatment of allergic disease, one major aim of this project is to extend her research program to study the effects of environmental microbial exposures on asthma. In addition, the candidate has a strong track record of mentoring trainees in patient-oriented research (POR) and proposes to develop advanced mentorship skills with a combination of didactic and mentored learning. Thus, the second aim of this proposal is to protect her time for mentorship and further development of mentoring skills. The mentorship skills and research development will occur, in part, in the context of the proposed research project, which aims to test the hypothesis that environmental exposure to SE+ S. aureus causes asthma morbidity in urban children in a SE-specific IgE dependent manner.

描述（由申请人提供）：候选人目前是约翰·霍普金斯大学的儿科副教授，也是一名儿科过敏症专家/免疫学家、流行病学家和环境健康科学家，其广泛的职业目标是了解环境对哮喘的影响，产生可行且可操作的公共卫生干预措施，以预防哮喘并降低哮喘发病率。由于必须了解微生物、过敏原和污染物之间复杂的相互作用，以便在预防和治疗过敏性疾病的环境控制策略方面取得重大进展，因此该项目的一个主要目标是扩展她的研究计划，以研究环境影响微生物暴露对哮喘的影响。此外，该候选人在以患者为导向的研究（POR）中指导学员方面拥有良好的记录，并建议通过说教和指导学习相结合来培养高级指导技能。因此，该提案的第二个目标是保护她的指导时间和指导技能的进一步发展。指导技能和研究开发将部分地在拟议的研究项目的背景下进行，该项目旨在检验以下假设：环境暴露于 SE+ 金黄色葡萄球菌会以 SE 特异性 IgE 依赖性方式导致城市儿童哮喘发病。