Genome Integrity Training Program

基因组完整性培训计划

• 批准号: 9303424
• 负责人: SUSAN SMITH
• 金额: $ 18.64万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9303424
• 关键词: Training Programs; genome integrity

 DESCRIPTION (provided by applicant): Control of genome integrity is emerging as a key underlying force in human disease. The aim of the Genome Integrity training program at the New York University School of Medicine is to equip students for modern research in genome biology by providing an intellectually diverse and rigorous research environment that emphasizes the basic principles of genome organization and function. Specifically, the program aims at providing in depth understanding of the molecular mechanisms regulating chromosomal replication, repair, recombination, expression, and propagation, and understanding how these mechanisms function in the context of tissue homeostasis and cellular and organismal fitness. The proposed program is the only program at the NYUSOM that supports training with research on genome integrity as its main objective. A deep understanding of genome organization and function will provide students with an essential underpinning for research in a broad range of areas that will impact human health including cancer and infectious and inherited diseases. The Genome Integrity Program has 28 faculty mentors from five departments at NYUSOM and the Biology department at NYU with active genome integrity research programs that use a use a broad range of model organisms (bacteria, virus, yeast, flies, worms, mouse, and human cells) and techniques (structural biology, biochemistry, cell biology, single molecule analysis, genetics, genomics, proteomics, and systems analysis). The 28 Genome Integrity members are highly productive scientists with extensive mentoring experience. In the last 10 years, they have mentored a total of 91 predoctoral trainees, most of whom, are pursuing careers in science and medicine. This program will receive strong support from the NYUSOM and will benefit from aggressive recruitment efforts by the open graduate programs at the Sackler Institute at the NYUSOM that have attracted high-caliber graduate students including underrepresented minority students. Since genome integrity is an expanding field requiring unique intellectual and technical training, and we anticipate an eventual steady state number of 25-30 students in the program, we are requesting 6 pre-doctoral training slots per year. Training in the Genome integrity program will include (a) rigorous research training in the principal investigator's laboratory; (b) broad education in genome function, biochemistry, genetics, and cell biology; (c) Bioinformatics and Statistics, Nuclear Cell Biology, and Genome Integrity courses; (d) active participation in the Genome Integrity seminar series/presentation/journal club, and an annual retreat; (e) opportunities to hone grant-writing and presentation skills; (f) discussion groups and lectures focusing on issues of ethical conduct in science and career options for biology graduates; and (g) a three-tiered mentoring system consisting of a first- year faculty mentor, research advisor, and thesis committee.

 描述（由申请人提供）：基因组完整性控制正在成为人类疾病的关键潜在力量。纽约大学医学院基因组完整性培训计划的目的是通过提供以下内容为学生提供基因组生物学现代研究的装备。一个智力多样化且严谨的研究环境，强调基因组组织和功能的基本原理，具体而言，该项目旨在深入了解调节染色体复制、修复、重组、表达和传播的分子机制，并了解这些机制是如何发挥作用的。该项目是 NYUSOM 唯一支持以基因组完整性研究为主要目标的培训项目，将为学生提供基本的基因组组织和功能的了解。基因组完整性计划为影响人类健康的广泛领域的研究提供支持，包括癌症、传染病和遗传性疾病。基因组完整性计划拥有来自 NYUSOM 五个系和纽约大学生物系的 28 名教师导师，他们开展了活跃的基因组完整性研究计划。使用一个广泛的模型生物（细菌、病毒、酵母、苍蝇、蠕虫、小鼠和人类细胞）和技术（结构生物学、生物化学、细胞生物学、单分子分析、遗传学、 Genome Integrity 的 28 名成员是具有丰富指导经验的高产科学家，在过去 10 年中，他们指导了总共 91 名博士生，其中大多数正在从事科学和医学领域的职业生涯。该项目将得到 NYUSOM 的大力支持，并将受益于 NYUSOM 萨克勒研究所的开放研究生项目的积极招募工作，该项目吸引了包括少数族裔在内的高素质研究生。由于基因组完整性是一个不断扩大的领域，需要独特的智力和技术培训，我们预计该项目的学生人数最终稳定在 25-30 名，因此我们每年要求 6 个博士前培训名额。计划将包括（a）首席研究员实验室的严格研究培训；（b）基因组功能、生物化学、遗传学和细胞生物学的广泛教育；（c）生物信息学和统计学、核细胞生物学和基因组完整性课程； (d) 积极参与基因组完整性研讨会系列/演讲/期刊俱乐部以及年度静修会； (e) 磨练资助金写作和演讲技巧的机会； (f) 讨论小组和演讲技巧； 重点关注生物学毕业生的科学道德行为和职业选择问题的讲座；(g) 由一年级教师导师、研究顾问和论文委员会组成的三级指导体系。