Center for Appalachian Research in Environmental Sciences

阿巴拉契亚环境科学研究中心

基本信息

批准号：
9270969
负责人：
Xianglin Shi
金额：
$ 149.65万
依托单位：
UNIVERSITY OF KENTUCKY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-05-01 至 2022-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9270969
关键词：
Address Air Analytical Chemistry Appalachian Region Area Arsenic Asthma Atherosclerosis Awareness Bioinformatics Chemicals Child health care Chromium Chronic Disease Chronic Obstructive Airway Disease Clinical Collaborations Colorectal Cancer Communication Communities Community Outreach Complex Computational Biology Core Facility Development Diabetes Mellitus Disease Ecology Environment Environmental Health Environmental Risk Factor Exposure to Fostering Foundations Funding Genetic Predisposition to Disease Goals Health Health Professional Health Sciences Healthcare Heart Heart Diseases Heavy Metals Human Incidence Individual Integrative Medicine Interest Group Kentucky Leadership Longevity Malignant Neoplasms Malignant neoplasm of lung Medical Medical center Mentorship Metabolic Diseases Mining National Institute of Environmental Health Sciences Nickel Obesity Outcome Particulate Pilot Projects Population Positioning Attribute Public Health Pulmonary Heart Disease Radon Recruitment Activity Research Research Infrastructure Research Personnel Resources Rivers Rural Science Scientist Stimulus Structure Talents Toxic Environmental Substances Toxicology Training Training Activity Translations Universities Vision Water base career career development early life exposure innovation interest member metabolomics neonate novel population health programs socioeconomic disadvantage water quality

项目摘要

PROJECT SUMMARY – Overall The University of Kentucky Center for Appalachian Research in Environmental Sciences (UK-CARES) will establish an Environmental Health Sciences Core Center to enhance research capacity focused on major environmental health impacts to air and water quality that have been implicated in environmentally induced disease. This Center will provide advanced infrastructure and leading expertise, dedicated career development and mentorship, and community-engaged interactions to facilitate innovative discovery and new understandings of environmental factors in disease initiation, progression, and outcomes and their community impacts. The central hypothesis is that toxic environmental agents are contributors to the disproportionately high incidence of chronic diseases, e.g., cancers, cardiopulmonary disease, and metabolic disorders in Appalachian Kentucky and that the impacts of early exposure are especially harmful. UK-CARES draws on a strong and diverse base of environmental health science and community-engaged research to build environmental health research capacity to meet the needs of communities in three Area Development Districts in southeastern Kentucky: Big Sandy, Kentucky River, and Cumberland Valley. Center members bring notable strengths in environmental health across four Research Interest Groups: Cardiopulmonary Diseases, Metabolic Disorders, Cancer, and Child Health and Early Life Exposures. To achieve the Center’s goal, UK-CARES will: 1) establish a rich research environment and a framework for transdisciplinary leadership and integrated infrastructure to facilitate collaboration and efficient use of resources for research expansion and development of new scientific directions; 2) build research capacity in environmental health sciences by providing an outstanding intellectual environment and advanced infrastructure to support innovation and community engagement; 3) recruit new talent and facilitate career development of investigators whose research addresses critical issues in environmentally induced disease through mentorship and structured career training activities; 4) develop multi-directional and mutually beneficial communications and interactions with community residents, policymakers, and public health/healthcare professionals to identify environmental concerns of target communities as a stimulus to new research; and 5) bridge the gap between discovery of novel research findings and population-level awareness and practice via community-focused science communication training. An Integrative Health Sciences Facility Core, Analytical Core, and Community Outreach and Engagement Core are integral to this effort and will catalyze multi-directional translation across the whole spectrum of research; provide advanced analytical support in metabolomics, computational biology, analytical chemistry, biospecimen management, and bioinformatics; and bridge Center and community priorities. Complementary activities in career development of scientists who are interested in tackling challenging environmental health questions and pilot project funding will support developing research and evolving scientific directions.

项目概要——总体肯塔基大学阿巴拉契亚环境科学研究中心 (UK-CARES) 将建立环境健康科学核心中心，加强重点专业的研究能力环境引起的对空气和水质的环境健康影响该中心将提供先进的基础设施和领先的专业知识，致力于职业发展。和指导以及社区参与的互动，以促进创新发现和新理解疾病发生、进展和结果的环境因素及其社区影响。中心假设是，有毒环境因素是造成不成比例的高发病率的原因之一。阿巴拉契亚肯塔基州的慢性疾病，例如癌症、心肺疾病和代谢紊乱早期暴露的影响尤其有害。UK-CARES 拥有强大而多样化的基础。环境健康科学和社区参与研究以建立环境健康研究满足肯塔基州东南部三个地区开发区社区需求的能力：大桑迪、肯塔基河和坎伯兰谷中心成员在环境方面具有显着的优势。四个研究兴趣组的健康：心肺疾病、代谢紊乱、癌症和儿童健康和早期生命暴露为了实现该中心的目标，UK-CARES 将： 1) 建立一个丰富的中心。研究环境、跨学科领导框架和综合基础设施，以促进协作和有效利用资源来扩展研究和开发新的科学方向； 2）通过提供优秀的智力环境来建设环境健康科学研究能力支持创新和社区参与的先进基础设施；3) 招募新人才；促进其研究解决环境关键问题的研究人员的职业发展 4）多方位发展与社区居民、政策制定者和公众进行互利的沟通和互动健康/医疗保健专业人员确定目标社区的环境问题作为新的刺激因素研究；5) 弥合新颖研究成果的发现与大众意识之间的差距通过以社区为中心的科学传播培训进行实践。核心、分析核心、社区外展和参与核心是这项工作的组成部分，并将促进整个研究领域的多向转化；提供先进的分析代谢组学、计算生物学、分析化学、生物样本管理等方面的支持生物信息学；以及桥接中心和社区优先事项的补充活动。对解决具有挑战性的环境健康问题和试点项目资金感兴趣的科学家将支持发展研究和不断发展的科学方向。