Center for Appalachian Research in Environmental Sciences Administrative Supplement for Cost Extension

阿巴拉契亚环境科学研究中心成本扩展行政补充

• 批准号: 10598337
• 负责人: Ellen J Hahn
• 金额: $ 22.95万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10598337
• 关键词: Address; Administrative Supplement; Air; Analytical Chemistry; Appalachian Region; Area; Arsenic; Asthma; Atherosclerosis; Awareness; Bioinformatics; Chemicals; Child Health; Chromium; Chronic Disease; Chronic Obstructive Pulmonary Disease; Clinical; Collaborations; Colorectal Cancer; Communication; Communities; Community Outreach; Complex; Computational Biology; Core Facility; Development; Diabetes Mellitus; Disease; Environment; Environmental Health; Environmental Risk Factor; Environmental Science; Exposure to; Fostering; Foundations; Funding; Genetic Predisposition to Disease; Goals; Health; Health Professional; Health Sciences; Healthcare; Heart; Heart Diseases; Heavy Metals; Human; Incidence; Individual; Infrastructure; Integrative Medicine; Interest Group; Kentucky; Leadership; Longevity; Malignant Neoplasms; Malignant neoplasm of lung; Medical; Medical center; Mentorship; Metabolic Diseases; Mining; National Institute of Environmental Health Sciences; Nickel; Obesity; Outcome; Particulate; Pilot Projects; Population; Positioning Attribute; Public Health; Pulmonary Heart Disease; Radon; Research; Research Personnel; Resources; Rivers; Rural; Science; Scientist; Stimulus; Strategic vision; Structure; Talents; Toxic Environmental Substances; Toxicology; Training; Training Activity; Translations; Universities; Water; advanced analytics; base; career; career development; community engaged research; community engagement; cost; early life exposure; health science research; hydraulic fracturing; innovation; interest; member; metabolomics; neonate; novel; population health; programs; recruit; socioeconomic disadvantage; water quality; Address; Administrative Supplement; Air; Analytical Chemistry; Appalachian Region; Area; Arsenic; Asthma; Atherosclerosis; Awareness; Bioinformatics; Chemicals; Child Health; Chromium; Chronic Disease; Chronic Obstructive Pulmonary Disease; Clinical; Collaborations; Colorectal Cancer; Communication; Communities; Community Outreach; Complex; Computational Biology; Core Facility; Development; Diabetes Mellitus; Disease; Environment; Environmental Health; Environmental Risk Factor; Environmental Science; Exposure to; Fostering; Foundations; Funding; Genetic Predisposition to Disease; Goals; Health; Health Professional; Health Sciences; Healthcare; Heart; Heart Diseases; Heavy Metals; Human; Incidence; Individual; Infrastructure; Integrative Medicine; Interest Group; Kentucky; Leadership; Longevity; Malignant Neoplasms; Malignant neoplasm of lung; Medical; Medical center; Mentorship; Metabolic Diseases; Mining; National Institute of Environmental Health Sciences; Nickel; Obesity; Outcome; Particulate; Pilot Projects; Population; Positioning Attribute; Public Health; Pulmonary Heart Disease; Radon; Research; Research Personnel; Resources; Rivers; Rural; Science; Scientist; Stimulus; Strategic vision; Structure; Talents; Toxic Environmental Substances; Toxicology; Training; Training Activity; Translations; Universities; Water; advanced analytics; base; career; career development; community engaged research; community engagement; cost; early life exposure; health science research; hydraulic fracturing; innovation; interest; member; metabolomics; neonate; novel; population health; programs; recruit; socioeconomic disadvantage; water quality

PROJECT SUMMARY – Overall The University of Kentucky Center for Appalachian Research in Environmental Sciences (UK-CARES) will establish an Environmental Health Sciences Core Center to enhance research capacity focused on major environmental health impacts to air and water quality that have been implicated in environmentally induced disease. This Center will provide advanced infrastructure and leading expertise, dedicated career development and mentorship, and community-engaged interactions to facilitate innovative discovery and new understandings of environmental factors in disease initiation, progression, and outcomes and their community impacts. The central hypothesis is that toxic environmental agents are contributors to the disproportionately high incidence of chronic diseases, e.g., cancers, cardiopulmonary disease, and metabolic disorders in Appalachian Kentucky and that the impacts of early exposure are especially harmful. UK-CARES draws on a strong and diverse base of environmental health science and community-engaged research to build environmental health research capacity to meet the needs of communities in three Area Development Districts in southeastern Kentucky: Big Sandy, Kentucky River, and Cumberland Valley. Center members bring notable strengths in environmental health across four Research Interest Groups: Cardiopulmonary Diseases, Metabolic Disorders, Cancer, and Child Health and Early Life Exposures. To achieve the Center’s goal, UK-CARES will: 1) establish a rich research environment and a framework for transdisciplinary leadership and integrated infrastructure to facilitate collaboration and efficient use of resources for research expansion and development of new scientific directions; 2) build research capacity in environmental health sciences by providing an outstanding intellectual environment and advanced infrastructure to support innovation and community engagement; 3) recruit new talent and facilitate career development of investigators whose research addresses critical issues in environmentally induced disease through mentorship and structured career training activities; 4) develop multi-directional and mutually beneficial communications and interactions with community residents, policymakers, and public health/healthcare professionals to identify environmental concerns of target communities as a stimulus to new research; and 5) bridge the gap between discovery of novel research findings and population-level awareness and practice via community-focused science communication training. An Integrative Health Sciences Facility Core, Analytical Core, and Community Outreach and Engagement Core are integral to this effort and will catalyze multi-directional translation across the whole spectrum of research; provide advanced analytical support in metabolomics, computational biology, analytical chemistry, biospecimen management, and bioinformatics; and bridge Center and community priorities. Complementary activities in career development of scientists who are interested in tackling challenging environmental health questions and pilot project funding will support developing research and evolving scientific directions.

项目摘要 - 总体 肯塔基大学阿巴拉契亚环境科学研究中心（英国）将 建立一个环境健康科学核心中心，以增强专注于主要的研究能力 环境健康对空气和水质的影响与环境诱导有关 疾病。该中心将提供高级基础设施和领先的专业知识，专门的职业发展 和精神训练以及社区参与的互动，以促进创新发现和新的理解 疾病启动，进展和结果及其社区影响的环境因素。这 中心假设是，有毒环境因素是导致不成比例的出现的贡献者 阿巴拉契亚肯塔基州的慢性疾病，例如癌症，心肺疾病和代谢性疾病 早期暴露的影响特别有害。英国 - 卡雷斯借鉴了强大而潜水的基础 环境健康科学和社区参与研究以建立环境健康研究 满足肯塔基州东南部三个地区发展区社区需求的能力：大 桑迪，肯塔基河和坎伯兰山谷。中心成员在环境中带来明显的优势 四个研究兴趣组的健康：心肺疾病，代谢疾病，癌症和 儿童健康和早期生活暴露。为了实现中心的目标，英国卡雷斯将：1）建立富人 研究环境和跨学科领导和综合基础设施的框架以促进 合作和有效利用资源来研究新科学方向的研究； 2）通过提供杰出的智力环境来建立环境健康科学的研究能力 以及支持创新和社区参与的高级基础设施； 3）招募新人才和 促进研究人员的职业发展，他们的研究解决了环境中的关键问题 通过心态和结构化的职业培训活动诱发疾病； 4）开发多方向和 与社区居民，政策制定者和公众的互惠交流以及互动 卫生/医疗保健专业人员确定目标社区的环境问题作为新的 研究; 5）弥合发现新研究发现与人群水平意识之间的差距 并通过以社区为重点的科学传播培训进行练习。综合健康科学设施 核心，分析核心以及社区外展和参与核心是这一努力不可或缺的一部分，将 在整个研究范围内催化多向翻译；提供高级分析 代谢组学，计算生物学，分析化学，生物测量管理和支持的支持 生物信息学；以及桥梁中心和社区优先事项。职业发展中的互补活动 有兴趣解决挑战环境健康问题和试点项目资金的科学家将 支持开发研究和发展科学方向。