Resiliency Among Older Adults Receiving Lung Cancer Treatment (ROAR-LCT): A Pilot Intervention Study
接受肺癌治疗的老年人的复原力 (ROAR-LCT):一项试点干预研究
基本信息
- 批准号:9811985
- 负责人:
- 金额:$ 11.6万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-08-15 至 2021-04-30
- 项目状态:已结题
- 来源:
- 关键词:Activities of Daily LivingAddressAdherenceAdultAffectAftercareAgingAntineoplastic AgentsAnxietyAwardChronic DiseaseClinic VisitsClinicalClinical TrialsCohort StudiesCombination Drug TherapyCombined Modality TherapyDataDiagnosisDiseaseDisease ProgressionElderlyEnrollmentFamilyFibrinogenFutureGeriatricsGoalsHealthHealth Care VisitHousekeepingImmune checkpoint inhibitorImpairmentIndividualInstitute of Medicine (U.S.)InterventionIntervention StudiesKnowledgeLeadershipLeisure ActivitiesLife ExpectancyMalignant NeoplasmsMalignant neoplasm of lungMental DepressionMentorshipMethodologyMuscle relaxation phaseNon-Small-Cell Lung CarcinomaOhioOncologistOperative Surgical ProceduresOutcomeParticipantPatientsPhysical PerformancePhysical activityPhysical therapyPilot ProjectsPopulationProspective cohort studyPsychologyQuality of lifeRelaxationRelaxation TherapyResearchResearch DesignResearch PersonnelRiskRisk FactorsScheduleSelf CareSupervisionSymptomsTestingTimeToxic effectTraining SupportUniversitiesWorkactive methodadvanced diseaseaging populationanticancer researchanxiety symptomscancer carecancer diagnosiscancer therapycohortdata archivedepressive symptomsdesigndisabilityexercise interventionexperiencefunctional disabilityfunctional independencefunctional lossfunctional outcomesfunctional statushealth related quality of lifeimprovedintervention programmodifiable risknegative moodnoveloncologypatient populationpatient subsetspreventprimary endpointresilienceresponseretention rateskillsstatisticssymptomatic improvementvirtual
项目摘要
PROJECT SUMMARY
Advanced non-small cell lung cancer (NSCLC) disproportionately affects older adults, but they are the least
studied in cancer research. Treatments for lung cancer are evolving rapidly, resulting in improved overall
survival even for patients with advanced disease. The impact of newer treatments such as immune checkpoint
inhibitors (ICIs) and combination therapy on functional status, the ability to recover worsening functional status
(resiliency), and clinical factors (i.e. treatment toxicity & disease response) for older adults is unknown. The
majority of older adults with cancer prioritize maintaining functional independence (i.e. no disability) over
survival. Despite this common desire among older adults, worsening functional status is a common
consequence of cancer treatment and is often not monitored throughout treatment. Among older adults with
NSCLC, symptoms such as anxiety, depression, and poor quality of life are common and are potential
determinants of whether patients are able to recover their functional status (resiliency) during treatment.
Interventions focusing on helping older adults to maintain functional status and improve resiliency at this time
are urgently needed. Dr. Presley's overall goal is to conduct research to understand the problem of functional
disability following cancer diagnosis and to develop empirically supported strategies to prevent the loss of
functional status in older adults with advanced lung cancer. To this end, the objectives of this application are:
1) to improve our understanding of functional status and resiliency among a cohort of older adults with
advanced NSCLC; and 2) to use this information to pilot a novel intervention targeting physical performance
and negative mood – two modifiable risk factors for worsening functional status among older adults undergoing
active treatment for advanced NSCLC. To meet these objectives, we will characterize functional status,
resiliency, and important clinical factors (i.e. treatment toxicity & disease response) in older adults with
advanced NSCLC in an ongoing prospective cohort study at The Ohio State University (Beating Lung Cancer
in Ohio). We will evaluate the association between clinical factors and outcomes: functional status and
resiliency in these patients. Refined with information from the first objective, a subset of patients will participate
in a pilot study, testing an intervention to improve functional status (via physical therapy) and reduce negative
mood (via progressive muscle relaxation, PMR) at regularly scheduled clinic visits in conjunction with virtual
health. The pilot intervention is designed to minimize treatment burden for this vulnerable patient population.
This will be one of the first studies to describe how treatment with ICIs affect older adults in terms of functional
status (i.e., activities of daily living and mobility). This award will provide the support necessary to advance Dr.
Presley's knowledge of intervention studies among older adults. Her mentorship team includes experts in
oncology, geriatrics, geriatric oncology, psychology, exercise interventions, & statistics, all selected to advance
Dr. Presley's research design, quantitative, project management, and leadership skills.
项目摘要
晚期非小细胞肺癌(NSCLC)对老年人的影响不佳,但最少
在癌症研究中进行的研究正在迅速发展,从而改善
即使是患有晚期疾病的患者的生存
抑制剂(ICI)和功能状态的组合疗法,恢复功能状况恶化的能力
(弹性)和老年人的临床因素(即治疗毒性反应)是未知的
大多数癌症的老年人优先维持功能独立性(即可介绍性)
生存。
癌症治疗的结果,通常不受监测的老年人治疗。
NSCLC,焦虑,抑郁和生活质量差等症状很普遍,潜力
在治疗期间,患者是否能够恢复其功能状况(弹性)的决定因素。
干预措施着重于帮助老年人保持功能状况并提高弹性
迫切需要。
癌症诊断后的残疾,并制定经验支持的策略,以防止失去
肺癌晚期的老年人的功能状况,该应用的目标是:
1)提高我们对与旧款的功能状态和韧性的理解。
高级NSCLC和2)使用此段落来实现针对身体的新型互动
和负面情绪 - 两个正在进行的老年人功能状况恶化的风险因素
高级NSCLC的主动处理,我们将表征功能状态
弹性和重要的临床因素(即治疗毒性和疾病反应)
高级NSCLC在俄亥俄州立大学正在进行的前瞻性队列研究中(击败肺癌
在俄亥俄州)。
这些患者的韧性与第一个目标的信息进行了完善
在一项试点研究中,测试一项干预措施以改善功能状态(通过物理疗法)并减少阴性
情绪(通过渐进的肌肉放松,PMR)在定期安排的诊所与虚拟诊所结合
健康。
这将是最早描述ICI治疗如何影响老年人的研究之一
地位(即日常生活和流动性的活动)。
Presley对老年人的干预研究知识。
肿瘤学,老年医学,老年肿瘤学,心理学,运动干预和统计数字都被选为进步
普雷斯利博士的研究设计,定量,项目管理和领导技能。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Carolyn Presley其他文献
Carolyn Presley的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Carolyn Presley', 18)}}的其他基金
Resiliency among Older Adults Receiving Lung Cancer Treatment: A Supportive Care Intervention Study
接受肺癌治疗的老年人的复原力:支持性护理干预研究
- 批准号:
10493276 - 财政年份:2021
- 资助金额:
$ 11.6万 - 项目类别:
Resiliency among Older Adults Receiving Lung Cancer Treatment: A Supportive Care Intervention Study
接受肺癌治疗的老年人的复原力:支持性护理干预研究
- 批准号:
10338882 - 财政年份:2021
- 资助金额:
$ 11.6万 - 项目类别:
相似国自然基金
时空序列驱动的神经形态视觉目标识别算法研究
- 批准号:61906126
- 批准年份:2019
- 资助金额:24.0 万元
- 项目类别:青年科学基金项目
本体驱动的地址数据空间语义建模与地址匹配方法
- 批准号:41901325
- 批准年份:2019
- 资助金额:22.0 万元
- 项目类别:青年科学基金项目
大容量固态硬盘地址映射表优化设计与访存优化研究
- 批准号:61802133
- 批准年份:2018
- 资助金额:23.0 万元
- 项目类别:青年科学基金项目
针对内存攻击对象的内存安全防御技术研究
- 批准号:61802432
- 批准年份:2018
- 资助金额:25.0 万元
- 项目类别:青年科学基金项目
IP地址驱动的多径路由及流量传输控制研究
- 批准号:61872252
- 批准年份:2018
- 资助金额:64.0 万元
- 项目类别:面上项目
相似海外基金
Biobehavioral Intervention to Reduce PTSD Symptoms After an ICD Shock
生物行为干预可减少 ICD 电击后的 PTSD 症状
- 批准号:
10722157 - 财政年份:2023
- 资助金额:
$ 11.6万 - 项目类别:
Using Artificial Intelligence to Predict Cognitive Training Response in Amnestic Mild Cognitive Impairment
使用人工智能预测遗忘型轻度认知障碍患者的认知训练反应
- 批准号:
10572105 - 财政年份:2023
- 资助金额:
$ 11.6万 - 项目类别:
Mindful Steps: A Web-Based Mind-Body Exercise Intervention to Promote Physical Activity in Chronic Cardiopulmonary Disease
正念步骤:基于网络的身心运动干预,促进慢性心肺疾病的体力活动
- 批准号:
10732824 - 财政年份:2023
- 资助金额:
$ 11.6万 - 项目类别:
Improving exercise rehabilitation efficacy and outcomes in Veterans with peripheral artery disease: Targeting oxidative stress and inflammation
提高患有外周动脉疾病的退伍军人的运动康复效果和结果:针对氧化应激和炎症
- 批准号:
10638943 - 财政年份:2023
- 资助金额:
$ 11.6万 - 项目类别:
Efficacy of Preoperative Oral Iron Supplementation in Adolescents Undergoing Scoliosis Surgery
术前口服铁补充剂对接受脊柱侧凸手术的青少年的疗效
- 批准号:
10785834 - 财政年份:2023
- 资助金额:
$ 11.6万 - 项目类别: