The Electronic Medical Records and Genomics (eMERGE) Network Phase III - Coordinating Center (U01)

电子病历和基因组学 (eMERGE) 网络第三期 - 协调中心 (U01)

• 批准号: 9134806
• 负责人: Joseph F. Peterson
• 金额: $ 96.63万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9134806
• 关键词: Agreement; Algorithms; Arbitration; Clinical; Collaborations; Computerized Medical Record; Data; Data Security; Development; Doctor of Philosophy; Electronics; Ensure; Ethics; Evolution; Excision; Generations; Genetic Medicine; Genomic medicine; Genomics; Genotype; Goals; Health; Heating; Human Genome; Incidental Findings; Informatics; Lead; Leadership; Legal; Libraries; Link; Logistics; Maps; Measures; Melissa; Memory; Methods; Mission; Modeling; National Human Genome Research Institute; Network Infrastructure; Patients; Pharmacogenomics; Phase; Phenotype; Quality Control; Research; Research Personnel; Research Project Grants; Resources; Role; Secure; Security Measures; Sequence Analysis; Site; Speed; Sum; Technology; Thinking; Translational Research; Translations; Universities; Variant; Washington; Work; biobank; data sharing; experience; genome sequencing; genome wide association study; genomic data; genomic tools; implementation research; innovation; legal implication; multidisciplinary; operation; prevent; programs; risk mitigation; social implication; success; support network; tool; variant of unknown significance; web site; working group

 DESCRIPTION (provided by applicant): The eMERGE Network has developed as a dynamic consortium, generating national impact on the use of EMRs for research and genomic medicine translation. As the eMERGE I and then the eMERGE II Coordinating Center (CC), we successfully combined scientific and logistical efforts of network sites to make significant progress, including: imputation and merging of GWAS data on 55,000 subjects with electronic medical records, 41 network-wide EMR phenotype deployments, development and integration of the eMERGE PGx project and research enabling tools such as PheKB and SPHINX. Building off of our success and following the stated goal of eMERGE III, our CC will continue as a hub for the Network by maintaining all of our current functions and evolving with the Network. The CC will remain responsible for cross-study functions, conducting quality control analyses of sequencing data, harmonizing data across studies, supporting cross-study analyses as needed, managing and upgrading the eMERGE Network website (gwas.org), facilitating outside collaborations, and organizing the logistics of the collaborative programs. As the eMERGE mission extends genomic discoveries research into genomic medicine practice research, we will bring both continuity and freshly envisioned innovations to support this important work, as illustrated in five proposed specific aims: (1) Extending informatics tools to accelerate phenotyping and facilitate end-to-end genomic medicine research. (2) Integrate high quality genomic information across eMERGE sites. (3) Secure EMR and genomic data sharing risk mitigation. (4) Provide excellent logistical support to the entire expanded network; including committees, work groups, NHGRI and the ESP. And finally, in keeping pace with national dynamics, we add (5) Synergize with other related networks to eliminate redundancy, promote cross pollination of best practices, and share eMERGE tools.

 描述（由适用提供）：Emerge网络已发展为一个动态财团，对使用EMR用于研究和基因组医学翻译产生了国家的影响。随着出现的I，然后是Emerge II协调中心（CC），我们成功地结合了网络站点的科学和后勤工作，以取得重大进展，包括：对55,000名具有电子病历的受试者的影响和合并，41个网络范围网络范围内的EMR EMR EMR表型部署，Emerge PGX PGX Project and sphin和Enlabling Enabling anlabling anlabling anlabling anlabling anlabling sembers anfling anlabling shimpers anbling shabling anlabling shabling anlabling shabling anlabling shabling anlabling sembers and eNabling。基于我们的成功并遵循Emerge III的既定目标，我们的CC将通过维护我们当前的所有功能并随着网络的发展而继续作为网络的枢纽。 CC将继续负责跨研究功能，进行测序数据的质量控制分析，跨研究协调数据，根据需要支持跨研究的分析，管理和升级Emerge网络网站（GWAS.org），支持外部协作以及组织协作计划的后勤工作。正如出现的任务扩展了基因组发现的基因组医学实践研究的研究时，我们将带来连续性和新鲜设想的创新以支持这项重要工作，如五个提出的特定目的所示：（1）扩展信息的工具来加强表型和支持端到端的基因组医学研究。 （2）整合跨出现站点的高质量基因组信息。 （3）安全EMR和基因组数据共享风险的缓解。 （4）为整个扩展的网络提供出色的后勤支持；包括委员会，工作组，NHGRI和ESP。最后，为了保持国家动态空间，我们补充了（5）与其他相关网络协同作用，以消除冗余，促进最佳实践的交叉授粉并共享出现的工具。