Midcareer Mentoring Award for Patient-Oriented Research in Chlamydia trachomatis Infection

沙眼衣原体感染以患者为导向的研究职业生涯中期指导奖

• 批准号: 9164066
• 负责人: WILLIAM M GEISLER
• 金额: $ 13.13万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-01 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9164066
• 关键词: 9 year old; Accident and Emergency department; Address; Adolescent and Young Adult; African American; Age; Alabama; American; Antibiotics; Antibodies; Antibody Response; Area; Award; Book Chapters; Characteristics; Chlamydia; Chlamydia trachomatis; Clinic; Clinical Investigator; Clinical Research; Clinical Sciences; Collaborations; Communicable Diseases; Conduct Clinical Trials; Detection; Development Plans; Doctor of Medicine; Dysuria; Enrollment; Enzyme-Linked Immunosorbent Assay; Epidemiology; Faculty; Fellowship Program; Female; Female Adolescents; Frequencies; Funding; Genital system; Genitourinary system; Goals; Grant; Guidelines; Health; Human; Infection; Infection Control; Infertility; Internal Medicine; Interview; Knowledge; Lead; Manuscripts; Master of Public Health; Medical; Medicine; Mentors; Nitrites; Pathway interactions; Patients; Persons; Physicians; Population; Pregnancy Outcome; Prevention; Primary Health Care; Provider; Publishing; Recruitment Activity; Reporting; Research; Research Personnel; Research Project Grants; Scientist; Serum; Sexual Partners; Sexually Transmitted Diseases; Source; Staging; Testing; Training; Training Programs; Translational Research; Universities; Urinary tract infection; Urine; Work; adolescent health; career; clinical care; effective therapy; experience; improved; ineffective therapies; interest; novel; patient oriented research; patient population; programs; reproductive morbidity; research study; screening; sexually active; skills; tool; treatment strategy; university student; urinary

William M. Geisler, M.D., M.P.H., is a mid-career stage physician scientist at the University of Alabama at Birmingham (UAB) with independent federal funding, expertise in Chlamydia trachomatis (CT) infections, and significant experience in mentoring early career stage trainees in patient-oriented research (POR). This midcareer investigator award would enable Dr. Geisler to: 1) further develop his mentoring skills, 2) continue providing POR mentoring to early career stage trainees, and 3) expand his research program in new directions by supporting two new research projects. CT infections are highly prevalent in young females (adolescents and young adults) and can cause significant reproductive morbidity when untreated. Since the majority of CT infections are asymptomatic, they are often unrecognized and may go untreated. CT detection relies in large part on screening young females annually. Because provider compliance with CT screening is low and screening at an annual interval misses many infections that resolve spontaneously or are incidentally treated, the cumulative burden of CT infection in asymptomatic young females is unknown. Another missed opportunity for treating CT infection is in females with CT-associated dysuria who are misdiagnosed with a urinary tract infection (UTI), often prescribed UTI treatment ineffective against CT, and usually not tested for CT. With award support, Dr. Geisler plans to expand and refine his mentoring skills through didactics and training, and to continue mentoring his current early stage trainees and recruit new trainees through multiple UAB sources. All trainees will be provided with educational and research experiences tailored to their career stage and interests. With award support, Dr. Geisler’s research program will be augmented through two new studies addressing missed opportunites for CT detection and treatment, which will provide new opportunities for mentoring trainees, collaborations, and funding. The Aim of New Study 1 is: Evaluate the cumulative burden of CT infection in female adolescents and young adults and predictors of higher burden. Females ages 16-29 years will be enrolled at 4 UAB clinics with different patient populations. Subjects will be interviewed and undergo urine CT testing and serum CT antibody testing. Cumulative burden of CT infection represents positivity by either test. The Aim of New Study 2 is: Determine the frequency of CT infection in female adolescents and young adults presenting with dysuria and the patient and urine characteristics that distinguish CT infection from UTI. Females ages 16-29 years presenting to the UAB Emergency Department with dysuria will be enrolled, interviewed, undergo urogenital CT testing, and have a urine dipstick and bacterial culture performed. The long-term goal of Dr. Geisler’s research is to improve prevention and control of CT infection. Knowledge from the new studies could lead to improve CT screening strategies in young asymptomatic females and more testing and treatment in females presenting with CT-associated dysuria. The research studies will provide mentoring opportunities in POR for multiple early stage trainees.

威廉·M·吉斯勒（M.D. 伯明翰（UAB）拥有独立的联邦资金，沙眼衣原体（CT）感染方面的专业知识以及 在心理早期职业阶段学员（POR）方面的重要经验。这 中级研究员奖将使盖斯勒博士能够：1）进一步发展他的心理技能，2）继续 为早期职业阶段培训提供POR心理，3）将其研究计划扩展到新方向 通过支持两个新的研究项目。 CT感染在年轻女性（青少年和 年轻人），未经治疗时可能会引起明显的复制发病率。由于大多数CT 感染是不对称的，通常无法识别，并且可能未经治疗。 CT检测很大 每年筛查年轻女性的一部分。因为提供者遵守CT筛查很低，并且 每年筛查会错过许多自发解决或偶然治疗的感染 不对称的年轻女性中CT感染的累积伯嫩尚不清楚。另一个错过的机会 用于治疗CT感染的是患有CT相关排尿症的女性，这些尿路被尿路诊断 感染（UTI），通常被规定的UTI治疗对CT无效，通常未对CT进行测试。 在奖励支持下，盖斯勒博士计划通过教学法和 训练，并继续为他当前的早期培训做心态，并通过多个招募新训练 UAB来源。所有学员将获得针对其职业生涯量身定制的教育和研究经验 舞台和兴趣。通过奖励支持，盖斯勒博士的研究计划将通过两个新的 研究解决CT检测和治疗机会的研究将提供新的机会 用于心理学员，合作和资金。新研究的目的是：评估累积 女性青少年和年轻人的CT感染负担以及负担更高的预测指标。女性老化 16 - 29年将在4个患者人群不同的UAB诊所招收。受试者将接受采访， 接受尿液CT测试和血清CT抗体测试。 CT感染的累积燃烧代表 两种测试的阳性。新研究的目的2是：确定女性CT感染的频率 伴有排尿和患者和尿液特征的青少年和年轻人区分 UTI感染CT。女性16-29岁的女性与排尿症一起向UAB急诊室介绍 将接受，采访，接受泌尿生殖器CT测试，并具有尿液量和细菌培养物 执行。盖斯勒博士研究的长期目标是改善对CT感染的预防和控制。 新研究的知识可能会改善年轻无症状的CT筛选策略 女性以及与CT相关排尿症呈现的女性进行更多的测试和治疗。研究 研究将为多个早期培训提供POR的心理机会。