Penn Resource-based Center to Support and Translate Skin DiseasesResearch

宾夕法尼亚大学资源中心支持和转化皮肤病研究

• 批准号: 9352776
• 负责人: Sarah E. Millar
• 金额: $ 84.93万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-15 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9352776
• 关键词: Advisory Committees; Applications Grants; Basic Science; Bioinformatics; Biology; Biometry; Budgets; Cells; Clinical; Collaborations; Communication; Community Outreach; Cutaneous; Data; Data Analyses; Dermatologic; Dermatology; Development; Disease; Engineering; Ensure; Faculty; Feasibility Studies; Feedback; Fostering; Foundations; Funding; Generations; Genetically Engineered Mouse; Goals; Grant; High School Student; Histology; Human; Human Resources; Immunology; In Vitro; Individual; Investigation; Mentors; Minority; Molecular; Mus; Names; Natural regeneration; Newsletter; Occupational activity of managing finances; Patients; Philadelphia; Pilot Projects; Productivity; Reagent; Research; Research Design; Research Personnel; Resources; Retreatment; Sampling; Schools; Scientist; Services; Skin; Speed; Structure; Students; Surveys; Techniques; Tissues; Translating; Translational Research; Translations; Woman; base; clinical practice; design; genome-wide analysis; human disease; in vivo; innovation; interest; investigator training; meetings; member; mouse model; new technology; news; outreach; outreach program; peer coaching; population based; pre-clinical; preclinical study; programs; public health relevance; research study; satisfaction; school district; skin disorder; success; tool; translational approach; web site

 DESCRIPTION (provided by applicant): Rapid translation of basic information in cutaneous biology to preclinical studies and clinical practice is becoming a realistic prospect due to the ever-increasing sophistication of basic research on development, regeneration, immunology, and diseases of the skin, together with powerful new technologies for gathering and analyzing genome-wide and population-based data. The overall goals of the proposed Penn SBDRC are to leverage our strengths in basic and translational science and dermatoepidemiology to support outstanding basic research in cutaneous biology and diseases and to promote the critical transition from bench research to bedside practice. To achieve these goals we will establish Resource and Administrative Cores. The Resource Cores are designed to enable and enhance the speed and efficiency of skin research; provide unique expertise and access to cutaneous tissues and specialized reagents; provide guidance on appropriate study design; provide easy access to biostatistical and bioinformatics support personnel; and continuously innovate to maintain our research at the forefront of the field. They are: Core A - Skin Histology and Characterization; Core B - Skin Procurement and Engineering; and Core C - Study Design and Data Analysis. The aims of the Administrative Core are to: provide structure and oversight for the SBDRC; ensure the diversity and success of researchers in cutaneous biology and diseases; attract new investigators to cutaneous research; and foster exchange of ideas, collaboration, and interdisciplinary and basic-translational projects. To achieve these Aims, the Administrative Core will: (i) establish an Executive Committee to provide financial management and oversight; (ii) organize an Advisory Committee of internal and external experts to provide feedback and suggest improvements, and a Diversity Advisory Committee to advise the Executive Committee on strategies to ensure diversity through best hiring and retention practices; (iii) provide administrative support to the SBDRC and Core Directors; (iv) organize specific mentoring programs for junior faculty, senior trainees, women and diversity faculty and trainees, and Core Directors; (v) organize monthly Peer Mentoring research presentations/grant application discussions; (vi) establish a Community Outreach Program to attract students from the predominantly minority Philadelphia school district to the excitement and promise of cutaneous research; (vii) provide Pilot & Feasibility Studies funding to support young investigators, interdisciplinary and/or basic-translational collaborations, and investigators from outside Dermatology interested in skin-oriented research; (viii) sponsor Seminars related to cutaneous biology and disease; (ix) hold an Annual Research Retreat; (x) organize Communications functions including a quarterly newsletter and an SBDRC website to advertise SBDRC seminars and meetings, Core services, and membership information.

 描述（通过应用程序提供）：皮肤生物学中的基本信息对临床前研究和临床实践的快速转化，由于对皮肤的发展，再生，免疫学和疾病的基础研究的社会化不断增强，以及针对全基因组和基于基于基因组和人群的数据，对皮肤的发展，再生，免疫学和皮肤疾病的不断增长。拟议的Penn SBDRC的总体目标是利用我们在基础和转化科学和Dermatoepidemiology方面的优势来支持皮肤生物学和疾病方面的杰出基础研究，并促进从基准研究到床边实践的关键过渡。为了实现这些目标，我们将建立资源和行政核心。资源核心旨在实现和提高皮肤研究的速度和效率；提供独特的专业知识并获得皮肤组织和专门的试剂；提供适当研究设计的指导；可轻松访问生物统计和生物信息学支持人员；并继续创新，以维持我们的研究处于该领域的最前沿。它们是：核心A-皮肤组织学和表征；核心B-皮肤采购和工程；和核心C-研究设计和数据分析。行政核心的目的是：为SBDRC提供结构和监督；确保研究人员在皮肤生物学和疾病中的多样性和成功；吸引新的研究人员进行皮肤研究；以及促进思想，协作以及跨学科和基本翻译项目的交流。为了实现这些目标，行政核心将：（i）建立一个执行委员会来提供财务管理和监督； （ii）组织一个内部和外部专家的咨询委员会，以提供反馈并提出改进，以及一个多样性咨询委员会，向执行策略委员会提供建议，以确保通过最佳雇用和保留惯例确保多样性； （iii）为SBDRC和核心董事提供行政支持； （iv）为初级教师，高级学员，妇女和多样性教师和学员以及核心主任组织特定的心理计划； （v）组织每月的同行指导研究演示/赠款申请讨论； （vi）建立一个社区外展计划，以吸引主要是少数费城学区的学生，以激发皮肤研究的兴奋和希望； （vii）提供试点和可行性研究资金，以支持年轻的研究人员，跨学科和/或基本翻译合作，以及来自外部皮肤病学对皮肤导向研究感兴趣的外部皮肤病学的研究者； （viii）与皮肤生物学和疾病有关的赞助商研讨会； （ix）举行年度研究务虚会； （X）组织通信功能包括季度新闻通讯和SBDRC网站，以宣传SBDRC下水道和会议，核心服务和会员信息。