Investigating information processing in parallel circuits that link external chemical signals to social behavior

研究将外部化学信号与社会行为联系起来的并行电路中的信息处理

基本信息

批准号：
9449930
负责人：
Julian P Meeks
金额：
$ 21.82万
依托单位：
UT SOUTHWESTERN MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-25 至 2019-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9449930
关键词：
3-Dimensional Accessory Olfactory Bulbs Afferent Neurons Amygdaloid structure Anxiety Area Arousal BRAIN initiative Behavior Behavioral Cell Extracts Cell Nucleus Chemicals Code Collaborations Cues Data Devices Emotions Estrogens Evaluation Foundations Future Goals Health Human Image Imaging Techniques Instinct Investigation Knowledge Label Laboratories Ligands Light Limbic System Link Measures Medial Mediating Methods Microfluidic Microchips Microfluidics Microscopy Mission Modeling Modernization Mus Neural Pathways Neurobiology Neurons Neurosciences Nose Olfactory Pathways Olfactory tract Optical Methods Pathway interactions Perception Peripheral Physiology Preparation Printing Property Reproduction Reproductive Behavior Research Research Infrastructure Research Project Grants Resolution Rodent Sensory Sexual Arousal Signal Transduction Site Social Behavior Sorting - Cell Movement Structure Structure of terminal stria nuclei of preoptic region System Techniques Territoriality analytical tool brain pathway cell type cranium design experience experimental study flexibility imaging modality improved in vivo information processing light weight mitral cell monolayer neural circuit neural model neuropsychiatric disorder open source prevent receptive field relating to nervous system sensory system social systems research technique development tool two-photon vomeronasal organ

项目摘要

Project Summary/Abstract The goal of this exploratory research project is to improve understanding about the mechanisms by which mammalian neural circuits decode environmental chemosensory information and use that information to support survival and reproduction. Specifically, the proposed research will investigate cell type-specific neural codes in the parallel brain pathways of the mouse accessory olfactory system (AOS). The AOS possesses a single neural circuit, the accessory olfactory bulb (AOB), that links the peripheral sensory neurons in the nose to powerful regions in the limbic system, but it remains unclear how information about naturally-occurring blends of social chemosignals is extracted through the AOB and its downstream targets. The exploratory research plan will utilize existing ex vivo approaches and collaboratively develop in vivo multi-site multielectrode AOS recording methods to investigate neuronal ensemble in the AOB and its downstream targets. This research will produce data linking sensory experience to “mission critical” mammalian behavioral states, and improve our understanding of mammalian physiology. The gains made by these studies and the establishment of new experimental and analytical tools will ultimately benefit human health.

项目摘要/摘要该探索性研究项目的目的是提高对机制的理解哺乳动物神经元电路解码环境化学感应信息，并将这些信息用于支持生存和繁殖。具体而言，拟议的研究将研究细胞类型特异性中性在小鼠辅助嗅觉系统（AOS）的平行脑通路中代码。 AO具有单个神经元电路，辅助嗅球（AOB），它连接了鼻子中的周围感觉神经元到边缘系统中强大的地区，但尚不清楚有关自然疾病的信息社会化学信号的混合物通过AOB及其下游目标提取。探索性研究计划将利用现有的离体方法，并在体内进行协作开发多电极AOS记录方法研究AOB中的神经元集合及其下游目标。这项研究将产生数据，将感官体验与“任务批判”哺乳动物行为联系起来国家，并提高我们对哺乳动物生理学的理解。这些研究和建立新的实验和分析工具最终将使人类健康受益。