Botanicals and Metabolic Resiliency

植物药和代谢弹性

• 批准号: 9512693
• 负责人: ZELPHA ELIZABETH FLOYD
• 金额: $ 182.87万
• 依托单位: LSU PENNINGTON BIOMEDICAL RESEARCH CTR
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9512693
• 关键词: Address; Adipocytes; Area; Artemisia; Baccharis; Biochemical; Biology; Biomedical Research; Botanical dietary supplements; Botanicals; Calcium; Cells; Characteristics; Clinical Trials; Complex; Data; Development; Disease; Environment; Exposure to; Faculty; Functional disorder; Funding; Future; Gene Expression; Grant; Health; Human; Human Biology; Image; Individual; International; Isothiocyanates; Knowledge; Louisiana; Melons; Mentors; Metabolic; Metabolic dysfunction; Metabolic syndrome; Methodology; Molecular; Momordica charantia; Moringa; Moringa oleifera; Non-Insulin-Dependent Diabetes Mellitus; Normal tissue morphology; Onset of illness; Outcome; Pathology; Phenotype; Pilot Projects; Plant Sources; Plants; Positioning Attribute; Process; Productivity; Public Health; Research; Research Personnel; Research Project Grants; Resistance; Resources; Role; Secondary to; Standardization; Stress; System; Technology; Tissues; Trigonella; Trigonella foenum-graecum; United States National Institutes of Health; Universities; base; environmental stressor; flexibility; functional genomics; fundamental research; gut microbiome; improved; in vivo; individual response; individual variation; innovation; interest; novel; obesity development; obesogenic; pre-clinical; programs; public health relevance; recruit; resilience; response; screening program; translation to humans

 DESCRIPTION (provided by applicant): This application is for a renewal of our Botanical Dietary Supplement Research Center. Our Botanical Research Center is a collaborative effort between the Pennington Biomedical Research Center of the Louisiana State University (LSU) System and the Department of Plant Biology and Pathology of Rutgers University. The theme of the Center is "Botanicals and Metabolic Resiliency". Specifically, our Center is poised to take the next logical scientific step in evaluating the role of botanicals for promoting human health by specifically focusing on the functional aspects and mechanisms by which botanicals promote metabolic resilience and general health. As such, our botanical research center will pursue exciting, novel, and in-depth hypotheses with specific emphasis on cellular mechanisms of action by which botanicals preserve and maintain normal tissue function and resist tissue dysfunction when exposed to significant environmental stressors, such as occur as part of an obesogenic environment. The resiliency promoted by botanicals will maintain whole body health. We refer to this characteristic as "botano-metabolic resiliency." Our Botanical Research Center will consist of three (3) highly collaborative research projects, an Integrative Biology Core, a Botanical core, and an Administrative core. Our Center has three aims which will promote a collaborative and interactive research environment, will identify and evaluate botanicals with potential efficacy in promoting metabolic resiliency, and will expand the critical mass of investigators addressing botanical research. For this grant cycle, we are proposing to expand studies on botanicals for which we have significant data (Artemisia sp, Projects 1 and 2), while also evaluating promising new leads (i.e., Groundsel bush [Baccharis halimifolia]) identified in our innovative screening program. In addition, we will study botanicals that are of great interest to the US consumer and of public health interest and whose mechanisms of action appear central to our theme (i.e., Trigonella foenum gracecum [fenugreek], Moringa oleifera Lam., and Momordica charantia [bitter melon]) (Projects 1, 2, 3). We have added additional state-of-the-art methodologies (e.g, live cell calcium imaging, gut microbiome assessment) and propose to specifically leverage our expertise in functional genomics/gene expression by exploring the individual variability in responses to botanicals.

 描述（由申请人提供）：本申请旨在更新我们的植物膳食补充剂研究中心。我们的植物研究中心是路易斯安那州立大学 (LSU) 系统彭宁顿生物医学研究中心和植物生物学系的合作项目。该中心的主题是“植物药和代谢弹性”，具体来说，我们的中心准备采取下一个合乎逻辑的科学步骤来评估植物药的作用。促进人类健康 特别关注植物药促进代谢弹性和整体健康的功能方面和机制，因此，我们的植物研究中心将追求令人兴奋的、新颖的和深入的假设，特别强调植物药保存和维持的细胞作用机制。当暴露于显着的环境压力源时，例如作为致胖环境的一部分，植物性物质促进的弹性将维持整个身体的健康。我们的植物研究中心将由三 (3) 个高度协作的研究项目组成：一个综合生物学核心、一个植物学核心和一个行政核心。我们中心的三个目标将促进协作和互动的研究环境，将确定并评估植物药在促进代谢弹性方面的潜在功效，并将扩大从事植物学研究的研究人员的临界数量。在本资助周期中，我们建议扩大对我们拥有大量数据的植物药的研究。 （Artemisia sp，项目 1 和 2），同时还评估我们的创新筛选计划中发现的有前景的新线索（即 Groundsel Bush [Baccharis halimifolia]）。此外，我们将研究美国消费者和消费者非常感兴趣的植物。具有公共卫生利益，其作用机制似乎是我们主题的核心（即胡芦巴 [葫芦巴]、辣木和Momordica charantia [苦瓜]）（项目 1、2、3）我们添加了其他最先进的方法（例如活细胞钙成像、肠道微生物组评估），并建议专门利用我们在功能基因组学方面的专业知识。 /基因表达，通过探索对植物反应的个体差异。