Ventral Hippocampus Circuits Underlying Conditioned Feeding Behavior

条件性进食行为背后的腹侧海马回路

基本信息

批准号：
9612210
负责人：
Clarissa Liu
金额：
$ 2.85万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-01 至 2021-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9612210
关键词：
Ablation Acute Adolescent Adult Affect Anatomy Appetitive Behavior Atlases Behavior Behavioral Mechanisms Behavioral Paradigm Biological Neural Networks Brain Brain region Calories Caspase Child Chronic Clozapine Communication Comorbidity Complex Consumption Cues Data Desire for food Development Discrimination Eating Epidemic Feeding behaviors Food Goals Heart Diseases Hippocampus (Brain)Hunger Hyperphagia Hypothalamic structure Individual Injections Label Lateral Lateral Hypothalamic Area Lead Learning Ligands Link Maps Medial Mediating Memory Metabolic Methodology Methods Modeling Neural Pathways Neurobiology Neurons Non-Insulin-Dependent Diabetes Mellitus Obesity Output Overweight Oxides Palate Pathway interactions Play Prefrontal Cortex Prevalence Procedures Public Health Publications Publishing Rattus Research Rewards Rodent Role Satiation Specific qualifier value Stimulus Stroke Synapses System Techniques Testing Time Tracer United States Viral anterograde transport base behavioral pharmacology cancer type computerized data processing deprivation designer receptors exclusively activated by designer drugs experience experimental study feeding innovation memory process mortality neural circuit neurobiological mechanism neurotransmission novel obesity treatment programs recombinase-mediated cassette exchange relating to nervous system

项目摘要

7. PROJECT SUMMARY/ABSTRACT Over the past 30 years, the obesity epidemic has grown such that more than 2 in 3 adults are classified as overweight or obese, and about 1 in 6 children and adolescents are considered to have obesity 1,7. The alarming increase in the prevalence of obesity is in large part due to the increasing size and number of meals that people consume 33,34, which are often influenced by learned experiences and environmental food- associated cues that can drive an individual to eat beyond metabolic/energy need 10,11. Recent publications from our lab4,5 indicate an important role for ventral hippocampus (CA1v) projections to the lateral hypothalamic area (LHA) and medial prefrontal cortex (mPFC) in mediating conditioned and motivated aspects of feeding behavior. However, CA1v neural pathways and behavioral mechanisms for the integration of food-related internal and environmental cues are not fully characterized. The goals of this proposal are to [1] map primary 1st-order projections of CA1v neurons, [2] identify collateral pathways branching from CA1v>mPFC and CA1v>LHA pathways, and [3] determine 2nd-order projection outputs of CA1v>mPFC and CA1v>LHA pathways (Aim I). This proposal also aims to test the functional relevance of CA1v>mPFC and CA1v>LHA pathways to higher-order aspects of feeding by combining viral-mediated disconnection of CA1v pathways with rodent feeding-relevant behavior paradigms that probe memory processes related to internal and external feeding-relevant cues (Aim II). Overall proposed experiments assess multiple levels of analyses and utilize state-of-the-art methodologies, including conditional virogenetic neural pathway tracing and functional chemogenetic methods to unravel the neural circuits that connect learning and memory with feeding behavior.

7。项目摘要/摘要在过去的30年中，肥胖症的流行已增长，使得超过三分之二的成年人被分类由于超重或肥胖，大约有6个儿童和青少年被认为具有肥胖1,7。这肥胖症患病率令人震惊，这在很大程度上是由于大小和饭菜数量增加人们消耗33,34 相关的提示可以驱使个人饮食超出代谢/能量需要10,11。最近的出版物我们的LAB4,5表明腹侧海马（CA1V）对下丘脑的投影的重要作用喂养条件和动机方面行为。但是，CA1V神经途径和与食物相关的整合的行为机制内部和环境线索尚未完全表征。该提议的目标是[1]地图主要 CA1V神经元的一阶投影，[2]识别从CA1V> MPFC和 CA1V> LHA途径，[3]确定CA1V> MPFC和CA1V> LHA的2阶投影输出途径（AIM I）。该建议还旨在测试CA1V> MPFC和CA1V> lha的功能相关性通过将CA1V途径的病毒介导的断开连接与啮齿动物喂养与内部和外部有关的记忆过程的相关行为范例喂养相关的提示（AIM II）。总体建议的实验评估了多个分析级别并利用最先进的方法论，包括有条件的病毒神经途径跟踪和功能化学发生方法可以揭示将学习和记忆与喂养行为联系起来的神经回路。