Effects of cholinergic axonal plasticity on spatial orientation

胆碱能轴突可塑性对空间定向的影响

基本信息

批准号：
9590726
负责人：
DOUGLAS WALLACE
金额：
$ 40.82万
依托单位：
NORTHERN ILLINOIS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-15 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9590726
关键词：
Adult Age Aging-Related Process Alzheimer&apos s Disease Animal Model Animals Antibodies Attenuated Auditory Behavioral Brain Caregivers Chronic Cognitive deficits Cues Deafferentation procedure Dementia Development Diagnosis Disease Disorientation Effectiveness Environment Foundations Goals Growth Factor Gene Health care facility Hippocampus (Brain)Home environment Human Immunotherapy Impairment Injury Intervention Learning Left Life Long-Term Care Modality Modeling Motor Movement NGFR Protein Neighborhoods Nerve Growth Factors Neurodegenerative Disorders Neuronal Plasticity Nociception Participant Pathology Patients Performance Phase I Clinical Trials Population Process Proprioception Public Health Rattus Research Resources Rodent Model Role Science Signal Pathway Signal Transduction Societies Source Space Perception Spinal cord injury Stroke Structure System Techniques Therapeutic Intervention Therapeutic Uses Time Training Transgenic Mice Traumatic Brain Injury Visual Work age effect age related aged analog automobile accident basal forebrain basal forebrain cholinergic neurons career cholinergic demographics economic impact effective therapy experience experimental study falls gene therapy graduate student improved information processing kinematics nervous system disorder neuropathology nonhuman primate novel novel therapeutic intervention novel therapeutics prevent retrograde transport senescence septohippocampal translational model undergraduate student

项目摘要

Project Summary/Abstract Neurodegenerative disorders can produce significant impairments in a patient’s ability to maintain spatial orientation. The current changing age structure of the US population in combination with lack of effective treatments for neurodegenerative disorders presents serious challenges for society in the management of these patients. Evaluating novel therapies for neurodegenerative disorders will depend on identifying an appropriate animal model of spatial orientation. Rats, like humans, use environmental and self-movement cues to maintain spatial orientation. My research has focused on developing tasks for rats that dissociate the use of either source of information. The basal forebrain cholinergic projections undergoes significant degeneration during the progression of Dementia of the Alzheimer's Type. The experiments outlined in this proposal represent the next step in investigating the potential of enhancing neuroplasticity to improve cognitive deficits associated with pathology in the basal forebrain cholinergic neurons. One goal of the proposal examines whether anti-Nogo-A immunotherapy is sufficient to promote neuroplasticity basal forebrain cholinergic neurons in adult and senescent rats. Another goal is to evaluate the extent that enhanced neuroplasticity at either age is sufficient to ameliorate self-movement cue processing deficits. A final goal is to provide training experiences for undergrad and graduate students that will establish a foundation to pursue a career in the biomedical sciences. The results of these studies will advance our understanding of the effects of aging on spatial orientation and evaluate the potential of anti-Nogo-A immunotherapies as a novel intervention for neurodegenerative disorders.

项目摘要/摘要神经退行性疾病可以在患者维持空间的能力方面产生重大损害方向。美国人口的当前年龄结构不断变化，缺乏有效神经退行性疾病的治疗对社会的管理提出了严重的挑战这些患者。评估神经退行性疾病的新型疗法将取决于确定适当的空间取向动物模型。像人类一样，老鼠使用环境和自动提示保持空间取向。我的研究重点是为消除使用使用的老鼠制定任务任何信息来源。基本的前脑胆碱能项目经历了重大退化在阿尔茨海默氏症类型的痴呆症中。该提案中概述的实验代表调查增强神经塑性以改善认知缺陷的潜力的下一步与基本前脑胆碱能神经元中的病理相关。提案考试的目标之一抗Nogo-A免疫疗法是否足以促进神经可塑性基本前脑胆碱能成人和感觉大鼠的神经元。另一个目标是评估增强神经可塑性的程度任何一个年龄都足以改善自动化提示处理缺陷。最终目标是提供培训本科生和研究生的经验，他们将建立基础来从事职业生物医学科学。这些研究的结果将提高我们对衰老影响的理解空间取向并评估抗Nogo-A免疫疗法的潜力作为新颖的干预措施神经退行性疾病。

项目成果

期刊论文数量（1）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

DOI：
10.1016/j.beproc.2022.104713
发表时间：
2022-09
期刊：
BEHAVIOURAL PROCESSES
影响因子：
1.3
作者：
Oltmanns, J. R. Osterlund;Schaeffer, E. A.;Blackwell, A. A.;Lake, R. I.;Einhaus, R. M.;Kartje, G. L.;Wallace, D. G.
通讯作者：
Wallace, D. G.