Role of the Cholinergic system in spatial orientation

胆碱能系统在空间定向中的作用

基本信息

批准号：
7012610
负责人：
DOUGLAS WALLACE
金额：
$ 21.75万
依托单位：
NORTHERN ILLINOIS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-01-01 至 2009-08-15
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Spatial orientation depends on the integrity of multiple neural systems. Acute or chronic neurological conditions that disrupt any of these systems can produce profound impairments in an individual's ability to remain spatially oriented within an environment. The lack of an effective treatment for Topographical Disorientation (TD), in combination with an aging population in which a growing number of individuals will be at risk for sustaining a stroke or developing AD, presents serious challenges for society in the management of these patients. Developing a treatment for TD will depend on the identification of an appropriate animal model of spatial orientation and the application of this model to investigate the contribution of specific neurotransmitter systems to spatial orientation. Previous work examining the neural basis of spatial orientation has focused on the use of navigational strategies that depend on landmarks in the environment; however, humans also use navigational strategies that are independent of environmental landmarks. The choice of navigational strategy depends on cue availability and environmental familiarity. The experiments outlined in this proposal continue a research program investigating the neural basis of spatial orientation The following goals were developed to establish the role of the cholinergic system in spatial orientation: 1) investigate the ability of the rodent model to dissociate the effects of cholinergic deafferentation of the hippocampus and cortex on spatial orientation, 2) examine the effectiveness of cholinergic treatments on restoring spatial orientation, 3) investigate the role of intact brain structures in mediating the recovered spatial orientation observed subsequent to cholinergic treatments. Establishing that cholinergic deafferentation fractionates the navigational strategies that are critical for spatial orientation reflects a novel framework for understanding TD. These studies will advance our understanding of the neural basis of spatial orientation, and the results may have implications for developing treatments for TD.

描述（由申请人提供）：空间取向取决于多个神经系统的完整性。破坏这些系统中任何一种的急性或慢性神经系统条件都会在个人在环境中保持空间取向的能力产生深远的损害。缺乏对地形迷失方向（TD）的有效治疗方法，结合了衰老的人口，越来越多的人将面临中风或发展广告的风险，对这些患者的管理给社会带来了严重的挑战。开发TD处理将取决于鉴定适当的空间取向动物模型，并应用该模型来研究特定神经递质系统对空间取向的贡献。先前检查空间取向神经基础的工作集中在使用依赖环境中标记的导航策略；但是，人类还使用独立于环境地标的导航策略。导航策略的选择取决于提示可用性和环境熟悉度。该提案中概述的实验继续一项研究计划，研究了空间取向的神经基础，以下目标建立了胆碱能系统在空间取向中的作用：1）研究啮齿动物模型消除胆碱能脱离胆碱能对海马和刚果疗法的胆碱能力效果的能力，对Spatial cortry on spatial pation of spatial patiention of Spatial patiention，2）cortian patiention，2）cortriention cortriention，2）cortriention cortriention of contirestion，2）促进了2）范围造成胆碱能力的效果。空间取向，3）研究完整的大脑结构在介导胆碱能处理后观察到的恢复的空间取向中的作用。确定胆碱能的脱依性分数对空间取向至关重要的导航策略反映了理解TD的新框架。这些研究将提高我们对空间取向神经基础的理解，结果可能对开发TD的治疗有影响。

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Organization of food protection behavior is differentially influenced by 192 IgG-saporin lesions of either the medial septum or the nucleus basalis magnocellularis.

DOI：
10.1016/j.brainres.2008.09.018
发表时间：
2008-11-19
期刊：
BRAIN RESEARCH
影响因子：
2.9
作者：
Martin, Megan M.;Winter, Shawn S.;Cheatwood, Joseph L.;Carter, Lynniece A.;Jones, Jeana L.;Weathered, Scott L.;Wagner, Steven J.;Wallace, Douglas G.
通讯作者：
Wallace, Douglas G.

Fractionating dead reckoning: role of the compass, odometer, logbook, and home base establishment in spatial orientation.

分段航位推算：指南针、里程表、航海日志和基地建立在空间定向中的作用。