Biospecimen and Biostatistics Core

生物样本和生物统计学核心

• 批准号: 9317443
• 负责人: Susan M Chang
• 金额: $ 31.19万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-27 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9317443
• 关键词: Animals; Archives; Area; Bioinformatics; Biometry; Biostatistics Core; Brain Neoplasms; Clinical; Clinical Research; Clinical Trials Database; Collection; Complex; Confidentiality of Patient Information; Data; Data Analyses; Databases; Development; Ensure; Equipment and supply inventories; Experimental Designs; Follow-Up Studies; Genomics; Glioblastoma; Goals; Grant; Histologic; Human; Human Resources; Image; Individual; Informed Consent; Instruction; Laboratory Research; Leadership; Link; Maintenance; Methods; Molecular; Molecular Analysis; Morphology; Pathology; Preparation; Procedures; Process; Property; Publications; Regulation; Research Design; Resources; Sample Size; Sampling; Schedule; Services; Statistical Data Interpretation; Statistical Models; Techniques; Testing; Tissue Sample; Tissues; Tumor Tissue; clinically relevant; design; epigenomics; human subject; image archival system; image guided; in vivo imaging; meetings; novel; programs; quality assurance; repository; translational impact; validation studies

The Biospecimen and Biostatistics Core, directed by Dr. Joanna Phillips, will provide the leadership and expertise needed to support the laboratory and clinical research of the 3 Projects in this POl grant. The decision to create a single Core covering these two areas reflects the need for using sophisticated approaches to evaluate the histological and genomic properties of tissue samples, as well to understand how to combine the complex, multi-parametric data obtained with the results from in vivo imaging data. The Biospecimen component will be led by Dr. Phillips, who will interact on an ongoing basis with the leaders of each Project to ensure that the acquisition distribution, and analysis of biospecimens meets the needs of the Projects. The following resources and services will be provided: the staff and expertise to collect, process, and archive image guided brain tumor samples and fresh brain tumor tissue; morphologic and relevant molecular analysis required by the Projects; neuropathologic expertise for interpretation of the processed tissue sections and extraction of appropriate quantitative parameters or ordinal scores; a tissue inventory and a database of associated molecular parameters that can be linked to the imaging and clinical databases; and stringent compliance with regulations governing informed consent and patient confidentiality, as well as management of the biospecimens and the information derived from the biospecimens. The Biostatistical component will be led by Dr. Molinaro, who will interact on an ongoing basis with the individual leaders from all three Projects to assess their statistical needs. Services will include: advice on the design of experimental and clinical studies, including calculating sample sizes and power; data analysis support (either by performing the analyses within the core or advising qualified personnel within the projects), developing appropriate statistical models and selecting tests of significance; and, when necessary, the development of novel methods to help interpret experimental results. Dr.Molinaro and her colleagues will participate in regularly scheduled project meetings to provide input on statistical and bioinformatics techniques, as well as assisting in the preparation of material for presentation and publication.

由乔安娜·菲利普斯（Joanna Phillips）博士执导的生物探测和生物统计学核心将提供领导和 在这项POL赠款中支持3个项目的实验室和临床研究所需的专业知识。这 决定创建覆盖这两个领域的单个核心的决定反映了使用复杂的需求 评估组织样品的组织学和基因选特性的方法，也了解如何了解 为了结合复杂的多参数数据，从体内成像数据中获得的结果。 Biospecimen组件将由Phillips博士领导，Phillips博士将与 每个项目的领导者，以确保采集分布和生物测量分析符合 项目的需求。将提供以下资源和服务：工作人员和专业知识 收集，过程和存档图像引导的脑肿瘤样品和新鲜的脑肿瘤组织；形态学 项目需要的相关分子分析；解释神经病理学专业知识 处理的组织切片和提取适当的定量参数或序数评分；组织 可以与成像和临床相关的相关分子参数的库存和数据库 数据库；严格遵守有关知情同意和患者机密性的法规， 以及生物测量的管理以及从生物测量中得出的信息。 生物统计组成部分将由Molinaro博士领导，Molinaro博士将与 来自所有三个项目的个人领导者来评估其统计需求。服务将包括：有关 实验和临床研究的设计，包括计算样本量和功率；数据分析 支持（通过在核心内执行分析，或在项目中建议合格的人员）， 开发适当的统计模型并选择重要性测试；而且，必要时， 开发新方法来解释实验结果。 Molinaro博士和她的同事将 参加定期安排的项目会议，以提供有关统计和生物信息学的意见 技术，并协助准备材料以进行演示和出版。