Sympathetic-somatomotor coupling in human SCI

人类 SCI 中的交感神经-躯体运动耦合

• 批准号: 9281921
• 负责人: Thomas George Hornby
• 金额: $ 31.72万
• 依托单位: MARQUETTE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-15 至 2020-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9281921
• 关键词: Acute; Address; Affect; Afferent Pathways; Blood Pressure; Blood Vessels; Blood flow; Cardiac Output; Cardiovascular system; Cervical; Chronic; Clinical; Clinical Management; Communication; Coupling; Cross-Over Studies; Data; Doppler Ultrasound; Efferent Pathways; Elbow; Electrocardiogram; Ergometry; Exercise; Exertion; Experimental Designs; Fatigue; Gait; Gait speed; Hand; Heart Rate; Human; Hyperreflexia; Individual; Injury; Joints; Knee; Mathematics; Measurement; Measures; Metabolic; Methods; Motor; Motor output; Movement; Muscle; Paralysed; Physical Fitness; Physical activity; Psyche structure; Randomized; Recovery of Function; Reflex action; Regulation; Rehabilitation therapy; Research Design; Research Project Grants; Skeletal Muscle; Spastic Gait; Spinal; Spinal Cord; Spinal Injuries; Spinal cord injury; Stimulus; Stress; Sympathetic Nervous System; System; Tendon structure; Testing; Therapeutic; Torque; Training; Training Programs; Volition; Walking; arm; base; blood flow measurement; design; exercise program; exercise rehabilitation; exercise training; experimental study; fitness; foot; improved; interest; limb movement; meetings; motor control; peripheral blood; public health relevance; rehabilitation management; response; spinal reflex; treadmill; treadmill training

DESCRIPTION (provided by applicant): The regulation of cardiovascular systems during muscle activity is poorly understood in people with incomplete spinal cord injury (SCI). In the past, disruptions in somatomotor and sympathetic control have been investigated separately in SCI. We propose to investigate the coupling of sympathetic and somatomotor control because it is relevant to exercise training paradigms that are designed to improve somatomotor function or enhance physical fitness. Our approach will be to measure tendon tap reflexes, voluntary muscle activation, and blood flow of the knee (below injury) and elbow (above injury) before and after sympathetic stimuli consisting of cold pressor tests, mental math and an acute bout of exercise. These data will provide information about sympathetic control of blood flow during muscle activity. Plasticity of the sympathetic- somatomotor coupling will also be investigated by making measurements before and after a treadmill training exercise program. These experiments will enable us to address three aims. Aim 1 will be to characterize coupling of sympathetic and somatomotor systems below the level of spinal injury. This aim will examine spinal sympathetic and motor reflexes and their interactions. It will also examine how descending somatomotor coupling is disrupted by the spinal injury. In Aim 2, we will identify changes in the interactions of sympathetic and somatomotor systems above a spinal injury. Because of the injury and the changes that occur below the injury, the sympathetic-somatomotor coupling is also likely to be disrupted in the arm. Aim 3 will then demonstrate plasticity of sympathetic-somatomotor coupling after exercise training. Three different eight week exercise training programs will be tested including 1) upper body ergometry, 2) treadmill training with exertion level matched to the upper body ergometry and 3) treadmill training with heart rate matched to an initial test of upper body ergometry. The exercise training will be tested in a randomized crossover study design with three months between exercise training paradigms. We anticipate that there will be plasticity of sympathetic-somatomotor coupling and that the exercise training effects will normalize control of these systems. However, because of the injury, we anticipate that adaptations will differ from non-injured controls. This study has implications for exercise training in human SCI. The coupling of sympathetic and somatomotor systems is expected to depend on whether exercise targets the upper or lower body. The recovery of function requires both the improvement in the control of movement as well as in the regulation of blood flow to active muscle groups. In addition, this study is important for understanding the potential impact of treadmill exercise training on cardiovascular fitness, a topic of increasing interest in people with limitations to physical activity.

描述（由申请人提供）：对于不完全脊髓损伤（SCI）患者，肌肉活动过程中心血管系统的调节知之甚少。过去，脊髓损伤中躯体运动和交感神经控制的破坏已分别进行了研究。我们建议研究交感神经和躯体运动控制的耦合，因为它与旨在改善躯体运动功能或增强身体素质的运动训练范例相关。我们的方法是在交感神经刺激前后测量肌腱拍打反射、随意肌肉激活以及膝盖（受伤以下）和肘部（受伤以上）的血流量，包括冷加压测试、心算和急性运动。这些数据将提供有关肌肉活动期间交感神经控制血流的信息。交感神经-躯体运动耦合的可塑性也将通过在跑步机训练计划之前和之后进行测量来研究。这些实验将使我们能够实现三个目标。目标 1 是表征脊髓损伤水平以下交感神经和躯体运动系统的耦合。这一目标将检查脊髓交感神经和运动反射及其相互作用。它还将检查脊髓损伤如何破坏下行躯体运动耦合。在目标 2 中，我们将确定脊髓损伤后交感神经系统和躯体运动系统相互作用的变化。由于损伤和损伤下方发生的变化，手臂中的交感神经-躯体运动耦合也可能被破坏。目标 3 将展示运动训练后交感神经-躯体运动耦合的可塑性。将测试三种不同的八周运动训练计划，包括 1) 上身测力计，2) 跑步机训练，用力水平与上身测力计相匹配，3) 跑步机训练，心率与上身测力计的初始测试相匹配。运动训练将受到考验 在一项随机交叉研究设计中，运动训练范式之间为期三个月。我们预计交感神经-躯体运动耦合将具有可塑性，运动训练效果将使这些系统的控制正常化。然而，由于受伤，我们预计适应将与未受伤的对照有所不同。这项研究对人类 SCI 的运动训练具有重要意义。交感神经系统和躯体运动系统的耦合预计取决于运动针对的是上半身还是下半身。功能的恢复需要改善运动的控制以及流向活跃肌肉群的血流的调节。此外，这项研究对于了解跑步机运动训练对心血管健康的潜在影响也很重要，心血管健康是身体活动受限的人们越来越感兴趣的话题。

项目成果

Muscle activation varies with contraction mode in human spinal cord injury.

人类脊髓损伤时，肌肉激活随收缩模式而变化。

• DOI: 10.1002/mus.24285
• 发表时间: 2015
• 期刊: Muscle & nerve
• 影响因子: 3.4
• 作者: Kim,HyosubE;Thompson,ChristopherK;Hornby,TGeorge
• 通讯作者: Hornby,TGeorge

Gains in Daily Stepping Activity in People With Chronic Stroke After High-Intensity Gait Training in Variable Contexts.

在不同环境下进行高强度步态训练后，慢性中风患者的日常行走活动有所增加。

• DOI: 10.1093/ptj/pzac073
• 发表时间: 2022
• 期刊: Physical therapy
• 影响因子: 3.2
• 作者: Hornby,TGeorge;Plawecki,Abbey;Lotter,JenniferK;Scofield,MollyE;Lucas,Emily;Henderson,ChristopherE
• 通讯作者: Henderson,ChristopherE

Improved walking function in laboratory does not guarantee increased community walking in stroke survivors: Potential role of gait biomechanics.

• DOI: 10.1016/j.jbiomech.2019.05.011
• 发表时间: 2019-06-25
• 期刊: Journal of biomechanics
• 影响因子: 2.4
• 作者: Ardestani MM;Henderson CE;Hornby TG
• 通讯作者: Hornby TG

Effect of investigator observation on gait parameters in individuals with stroke.

• DOI: 10.1016/j.jbiomech.2020.109602
• 发表时间: 2020-02-13
• 期刊: Journal of biomechanics
• 影响因子: 2.4
• 作者: Ardestani MM;Hornby TG
• 通讯作者: Hornby TG

Effects of Training Intensity on Locomotor Performance in Individuals With Chronic Spinal Cord Injury: A Randomized Crossover Study.

• DOI: 10.1177/1545968317731538
• 发表时间: 2017-10
• 期刊: Neurorehabilitation and neural repair
• 影响因子: 4.2
• 作者: Brazg G;Fahey M;Holleran CL;Connolly M;Woodward J;Hennessy PW;Schmit BD;Hornby TG
• 通讯作者: Hornby TG