Administrative Supplement to the Alzheimer's Disease Core Center - Neuropathology Core

阿尔茨海默病核心中心的行政补充 - 神经病理学核心

• 批准号: 9617989
• 负责人: MAREK-MARSEL M MESULAM
• 金额: $ 10万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-07-15 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9617989
• 关键词: Administrative Supplement; Age; Aging; Alzheimer' s Disease; Alzheimer' s Disease Core Center; Anatomy; Animals; Area; Award; Basic Science; Brain; Clinical; Clinical Research; Cognitive; Cognitive aging; Computer software; Data; Dementia; Densitometry; Disease; Education; Faculty; Failure; Fund Raising; Goals; Human; Investigation; Laboratories; Molecular; Neurodegenerative Disorders; Operating System; Postdoctoral Fellow; Primary Progressive Aphasia; Research; Research Personnel; Source; System; Techniques; Therapeutic; Training; Translational Research; Universities; cost; design; education research; experience; imager; in vitro Model; innovation; interest; molecular pathology; morphometry; multidisciplinary; neurochemistry; neuropathology; next generation

This application seeks support through an administrative supplement to the Northwestern University Alzheimer's Disease Center (NU-ADC) award to acquire a new system for unbiased stereological quantitation. Unbiased stereological quantitative analysis is a major component of “Aims 3 and 4” of the Neuropathology Core in the current award period, with the goal to “support the specialized research interests within Northwestern University on unusually successful cognitive aging (SuperAgers), on non-amnestic dementias such as primary progressive aphasia (PPA), and on non-AD pathologies related to FTLD…through stereology and densitometry for quantitative comparisons.” “Investigations such as these will draw heavily on the Neuropathology Core in the next 5 years…[and] are dependent on quantitative stereology” and availability of a functioning stereology system. Unbiased stereological quantitation is also an important component of achieving the broad NU-ADC goal to “train fellows and junior faculty and attract new investigators to dementia research”; of Aim 5 of the Neuropathology Core to “train the next generation of neuropathologists in a multidisciplinary setting that includes close interaction with clinicians, imagers and neuroanatomists and in a manner that serves the goals of the Research Education Component”; and of the Research Education Component goal “to enhance the education of doctoral candidates, post-doctoral fellows and faculty through innovative multidisciplinary mechanisms designed to bridge the gap between clinical and basic research experience in the areas of aging, AD and related disorders”. Finally, “anatomy and quantitation” are a distinct feature of the Neuropathology Core. As stated in the NU-ADC awarded renewal application, “The Cognitive and Molecular Morphometry Laboratory led by Dr. Geula combines immunohistochemical, stereologic, neuroanatomic, neurochemical and molecular expertise. The Laboratory has two main goals: 1) to promote the systems-level approach to dementias in a way that elucidates relationships among molecular pathology, its anatomic distribution, and clinical features, and 2) to promote translational research by facilitating transition of hypotheses from animal/in vitro models to human brain”. Our Center has a MicroBrightField (MBF) stereology system with the StereoInvestigator and Neurolucida operating systems. This system was acquired over 20 years ago and has been heavily used during this period, particularly in the last decade. Due to its age and heavy use, the system is gradually disintegrating, as evidenced by frequent failure of its components. For reasons described in the application, we have chosen to acquire a new MBF complete stereology system with StereoInvestigator and Neurolucida software. This system will allow all stereological determinations available in the field. We are requesting $100,000 to help with the purchase of a new MBF stereology system. This amount will cover part of the cost. We will raise funds from institutional and other sources for the remainder of the costs associated with acquiring this system.

该申请通过向西北大学的行政补充寻求支持 阿尔茨海默氏病中心（NU-ADC）奖，旨在获取一种新系统，用于无偏见的立体定量。 公正的立体定量分析是神经病理学“目标3和4”的主要组成部分 当前奖励期内的核心，目的是“支持内部专门的研究兴趣 西北大学异常成功的认知衰老（超级魔术师），非疾病痴呆症 例如主要的进行性失语症（PPA），以及与FTLD有关的非AD病理…… 定量比较的立体学和光密度法。”“这样的研究将大量吸引 在未来5年的神经病理学核心上……[和]取决于定量立体学”和 功能性的立体系统的可用性。公正的立体定量也是重要的 实现广泛的NU-ADC目标的组成部分，以“训练研究员和初级教师和吸引力新 神经病理学核心目标5 在多学科环境中的神经病理学家，包括与临床医生，成像者和 神经解剖学家，并以一种实现研究教育组成部分的目标的方式； 研究教育组成的目标“增强博士候选人的教育，博士后研究员 和通过创新的多学科机制的教师，旨在弥合临床和 在衰老，AD和相关疾病领域的基础研究经验”。最后，“解剖学和定量” 是神经病理学核心的独特特征。如NU-ADC授予的续签申请：“ Geula博士领导的认知和分子形态计量学实验室结合了免疫组织化学， 立体，神经解剖学，神经化学和分子专业知识。实验室有两个主要目标：1） 以阐明分子之间关系的方式促进系统级痴呆症的方法 病理学，其解剖分布和临床特征，以及2）通过促进转化研究 假设从动物/体外模型过渡到人脑”。我们的中心有一个Microbrightfield（MBF） 立体评估器和Neurolucida操作系统的立体学系统。该系统被获取 20年前，在此期间，尤其是在过去十年中。由于它的年龄 大量使用，该系统正在逐渐瓦解，这是由于其组件的经常失败所证明的。为了 应用程序中描述的原因，我们选择使用使用 立体评估器和Neurolucida软件。该系统将允许所有可用的立体论确定 在现场。我们要求100,000美元，以帮助购买新的MBF立体原系统。这 金额将支付一部分费用。我们将在其余的机构和其他来源筹集资金 与获取该系统有关的成本。