Evaluating the Head's Response to Impulsive Forces in Young Athletes

评估年轻运动员头部对冲动力的反应

• 批准号: 9094275
• 负责人: James Travis Eckner
• 金额: $ 13.21万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-15 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9094275
• 关键词: Acceleration; Address; Age; Anatomy; Area; Award; Biomechanics; Brain; Brain Concussion; Cervical; Characteristics; Child; Clinical; Clinical Oncology Supplement (K12); Clinical Research; Complex; Computer Simulation; Development Plans; Devices; Educational Status; Event; Female; Flexor; Funding; Future; Gender; Goals; Head; Head Movements; Head and neck structure; Health; Human; Individual; Inferior; Injury; Investigation; K-Series Research Career Programs; Laboratories; Lateral; Location; Measurable; Measurement; Measures; Mechanics; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Motion; Muscle; Musculoskeletal; Neck; Neurons; Outcome; Pattern; Physiatrist; Physical Medicine; Physical Rehabilitation; Positioning Attribute; Preventive; Protocols documentation; Research; Research Design; Research Support; Risk; Risk Factors; Role; Rotation; Skeletal muscle structure of neck; Speed; Sports; Statistical Data Interpretation; System; Techniques; Testing; Training; Ultrasonography; United States National Institutes of Health; Violence; Whiplash Injuries; Work; base; biomechanical engineering; biomechanical model; brain tissue; career; career development; clinically significant; design; disability; elastography; experience; head impact; high risk; human subject; improved; in vivo; kinematics; male; mild traumatic brain injury; muscle strength; novel; prediction algorithm; programs; response; skills; vector

DESCRIPTION (provided by applicant): Sport-related concussion occurs when linear and angular head motion caused by external physical forces disrupts an athlete's brain function at the neuronal level. Athletes with smaller, weaker necks, including child and female athletes, are thought to be at increased risk of concussion because their necks are less able to counter these externally acting forces resulting in more violent head movement patterns. The bi-directional whiplash motion that occurs when an athlete's head rapidly changes its direction of rotation may also increase the risk of concussion associated with an individual impact, as compared to a uni-directional rotation pattern of similar magnitude. The proposed biomechanical investigation will pursue the following specific aims: AIM 1) to determine the relationship between sonographic measures of cervical muscle size and stiffness and the head's kinematic response under a standardized impulsive force in each anatomical plane across the spectra of age and gender; AIM 2) to determine whether in vivo commercial impact sensing systems can predict bi-directional versus uni-directional rotation patterns, as determined by a high speed kinematic motion capture system, during a sport-simulated bracing task. The working hypotheses associated with these aims are: H1) the magnitudes of the head's linear and angular velocity changes will be negatively associated with cervical muscle size and stiffness and will be more strongly correlated with these sonographic measures than concurrently measured neck strength in each plane (AIM 1); H2) resultant impact vectors generated by commercial impact sensing systems that are located inferior of the head's center of mass will be associated with bi-directional head rotation patterns, while impact vector locations superior to the head's center of mass will be associated with uni-directional rotation (AIM 2). The Candidate has a clinical background in Physical Medicine and Rehabilitation with expertise in mild traumatic brain injury, specifically sport-related concussion. He has master's level training in clinical research design and statistical analysis as well as additional basic training and experience in biomechanical engineering principles and laboratory techniques. He is committed to a career in sport concussion research focusing on injury biomechanics and he plans to use the additional training he receives through this NIH Career Development Award to support his future work in this field. The Candidate and his mentoring team have designed a career development plan to accomplish three training goals: 1) become proficient in biomechanical modeling techniques to permit effective use and interpretation of basic biomechanical models of the human head and neck, 2) obtain expertise in musculoskeletal ultrasonography, allowing for proficient measurement of cervical muscle size (cross sectional area) and stiffness (elastography), 3) improve grantsmanship skills to facilitate ongoing research support.

描述（由申请人提供）：当外部物理力引起的线性和有角度的头部运动扰乱运动员的神经元水平的大脑功能时，就会发生与运动相关的脑震荡。颈部较小、较弱的运动员，包括儿童和女运动员，被认为发生脑震荡的风险增加，因为他们的颈部抵抗这些外部作用力的能力较差，导致头部运动模式更加剧烈。与类似幅度的单向旋转模式相比，当运动员的头部快速改变其旋转方向时发生的双向挥鞭运动也可能增加与个人撞击相关的脑震荡的风险。拟议的生物力学研究将追求以下具体目标：AIM 1）确定颈部肌肉尺寸和硬度的超声测量与年龄和性别范围内每个解剖平面标准化脉冲力下头部运动响应之间的关系；目标 2) 确定体内商业冲击传感系统是否可以预测在运动模拟支撑任务期间由高速运动捕捉系统确定的双向与单向旋转模式。与这些目目标 1); H2) 由位于头部质心下方的商业撞击传感系统生成的合成撞击矢量将与双向头部旋转模式相关联，而高于头部质心的撞击矢量位置将与单向头部旋转模式相关联。旋转（目标 2）。候选人具有物理医学和康复方面的临床背景，具有轻度创伤性脑损伤（特别是运动相关脑震荡）方面的专业知识。他接受过临床研究设计和统计分析方面的硕士学位培训，以及生物力学工程原理和实验室技术方面的额外基础培训和经验。他致力于运动脑震荡研究，重点关注损伤生物力学，并计划利用他通过 NIH 职业发展奖获得的额外培训来支持他未来在该领域的工作。候选人及其指导团队设计了职业发展计划，以实现三个培训目标：1) 精通生物力学建模技术，以便有效使用和解释人体头部和颈部的基本生物力学模型，2) 获得肌肉骨骼超声检查方面的专业知识，可以熟练测量颈肌大小（横截面积）和硬度（弹性成像），3) 提高资助技能，以促进正在进行的研究支持。

项目成果

A Clinical Approach to the Diagnosis of Traumatic Encephalopathy Syndrome: A Review.

• DOI: 10.1001/jamaneurol.2015.5015
• 发表时间: 2016-06-01
• 期刊: JAMA neurology
• 影响因子: 29
• 作者: Reams N;Eckner JT;Almeida AA;Aagesen AL;Giordani B;Paulson H;Lorincz MT;Kutcher JS
• 通讯作者: Kutcher JS

Is Migraine Headache Associated With Concussion in Athletes? A Case-Control Study.

• DOI: 10.1097/jsm.0000000000000346
• 发表时间: 2017-05
• 期刊: Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine
• 作者: Eckner JT;Seifert T;Pescovitz A;Zeiger M;Kutcher JS
• 通讯作者: Kutcher JS