Evaluating the Head's Response to Impulsive Forces in Young Athletes

评估年轻运动员头部对冲动力的反应

• 批准号: 8909150
• 负责人: James Travis Eckner
• 金额: $ 13.21万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-15 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8909150
• 关键词: Acceleration; Address; Age; Algorithms; Anatomy; Area; Award; Biomechanics; Braces-Orthopedic appliances; Brain; Brain Concussion; Cervical; Characteristics; Child; Clinical; Clinical Oncology Supplement (K12); Clinical Research; Complex; Computer Simulation; Development Plans; Devices; Educational Status; Event; Female; Flexor; Funding; Future; Gender; Goals; Head; Head Movements; Head and neck structure; Health; Human; Individual; Inferior; Injury; Investigation; K-Series Research Career Programs; Laboratories; Lateral; Location; Measurable; Measurement; Measures; Mechanics; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Motion; Muscle; Musculoskeletal; Neck; Neurons; Outcome; Pattern; Physiatrist; Physical Medicine; Physical Rehabilitation; Positioning Attribute; Preventive; Protocols documentation; Research; Research Design; Research Support; Risk; Risk Factors; Role; Rotation; Skeletal muscle structure of neck; Speed; Sports; System; Techniques; Testing; Training; Ultrasonography; United States National Institutes of Health; Violence; Whiplash Injuries; Work; base; biomechanical engineering; biomechanical model; brain tissue; career; career development; clinically significant; design; disability; elastography; experience; head impact; high risk; human subject; improved; in vivo; kinematics; male; mild traumatic brain injury; muscle strength; novel; programs; response; skills; vector

DESCRIPTION (provided by applicant): Sport-related concussion occurs when linear and angular head motion caused by external physical forces disrupts an athlete's brain function at the neuronal level. Athletes with smaller, weaker necks, including child and female athletes, are thought to be at increased risk of concussion because their necks are less able to counter these externally acting forces resulting in more violent head movement patterns. The bi-directional whiplash motion that occurs when an athlete's head rapidly changes its direction of rotation may also increase the risk of concussion associated with an individual impact, as compared to a uni-directional rotation pattern of similar magnitude. The proposed biomechanical investigation will pursue the following specific aims: AIM 1) to determine the relationship between sonographic measures of cervical muscle size and stiffness and the head's kinematic response under a standardized impulsive force in each anatomical plane across the spectra of age and gender; AIM 2) to determine whether in vivo commercial impact sensing systems can predict bi-directional versus uni-directional rotation patterns, as determined by a high speed kinematic motion capture system, during a sport-simulated bracing task. The working hypotheses associated with these aims are: H1) the magnitudes of the head's linear and angular velocity changes will be negatively associated with cervical muscle size and stiffness and will be more strongly correlated with these sonographic measures than concurrently measured neck strength in each plane (AIM 1); H2) resultant impact vectors generated by commercial impact sensing systems that are located inferior of the head's center of mass will be associated with bi-directional head rotation patterns, while impact vector locations superior to the head's center of mass will be associated with uni-directional rotation (AIM 2). The Candidate has a clinical background in Physical Medicine and Rehabilitation with expertise in mild traumatic brain injury, specifically sport-related concussion. He has master's level training in clinical research design and statistical analysis as well as additional basic training and experience in biomechanical engineering principles and laboratory techniques. He is committed to a career in sport concussion research focusing on injury biomechanics and he plans to use the additional training he receives through this NIH Career Development Award to support his future work in this field. The Candidate and his mentoring team have designed a career development plan to accomplish three training goals: 1) become proficient in biomechanical modeling techniques to permit effective use and interpretation of basic biomechanical models of the human head and neck, 2) obtain expertise in musculoskeletal ultrasonography, allowing for proficient measurement of cervical muscle size (cross sectional area) and stiffness (elastography), 3) improve grantsmanship skills to facilitate ongoing research support.

描述（由申请人提供）：与运动相关的脑震荡发生时，当外部物理力引起的线性和角头运动在神经元水平上破坏运动员的大脑功能。脖子较小，脖子较小的运动员（包括儿童和女运动员）被认为会增加脑震荡的风险，因为他们的脖子不太能够抵抗这些外部表现力，从而导致更剧烈的头部运动模式。与类似幅度的单向旋转模式相比，当运动员头迅速改变其旋转方向时，发生双向鞭打运动也可能增加与个体影响相关的脑震荡风险。拟议的生物力学研究将追求以下特定目的：目标1）确定颈肌大小和僵硬度的超声测量与头部在跨年龄和性别光谱的标准化冲动力下的头部的运动学反应之间的关系；目标2）确定在运动模拟的支撑任务中，在高速运动学运动捕获系统确定的情况下，是否可以预测双向和单向旋转模式。与这些目标相关的工作假设是：H1）头部线性和角速度变化的幅度将与宫颈肌肉的大小和刚度负相关，并且与这些平面的同时测量的颈部强度（目标1）; H2）由质量底部较低的商业冲击传感系统产生的影响向量将与双向头部旋转模式有关，而冲击向量位置优于头部质量中心，将与Uniwirectional有关旋转（目标2）。候选人具有物理医学和康复的临床背景，具有轻度创伤性脑损伤，特别是与运动有关的脑震荡方面的专业知识。他在临床研究设计和统计分析方面进行了硕士水平培训，以及生物力学工程原理和实验室技术方面的其他基本培训和经验。他致力于从事运动脑震荡研究的职业，专注于伤害生物力学，并计划利用他通过这项NIH职业发展奖获得的其他培训来支持他在这一领域的未来工作。候选人和他的指导团队设计了一项职业发展计划，以实现三个培训目标：1）熟练精通生物力学建模技术，以有效使用和解释人头和颈部的基本生物力学模型，2）获得肌肉骨骼超声检查方面的专业知识，允许熟练地测量宫颈肌肉大小（横截面区域）和刚度（弹性学），3）提高赠款技巧以促进正在进行的研究支持。