Gait and Balance Changes in Chemotherapy Induced Peripheral Neuropathy

化疗引起的周围神经病变的步态和平衡变化

• 批准号: 8624023
• 负责人: Ajit Mohan Worthen Chaudhari
• 金额: $ 7.69万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8624023
• 关键词: Activities of Daily Living; Affect; Area; Cancer Patient; Cancer Survivor; Colorectal Cancer; Data; Development; Dose-Limiting; Effectiveness; Effectiveness of Interventions; Elderly; Equilibrium; European Organization for Research and Treatment of Cancer; Exercise; Future; Gait; Goals; Incidence; Individual; Intervention; Knowledge; Laboratories; Lead; Length; Life; Malignant Neoplasms; Measures; Metric; Natural History; Nerve; Paclitaxel; Pain; Patient Outcomes Assessments; Patient Self-Report; Patients; Peripheral; Peripheral Nervous System Diseases; Pharmaceutical Preparations; Platinum; Population; Quality of life; Quantitative Evaluations; Relative (related person); Reporting; Research; Risk; Signs and Symptoms; Survivors; Symptoms; Taxane Compound; Testing; Time; Toxic effect; Treatment Effectiveness; Treatment Protocols; Vinca Alkaloids; Walking; Width; Work; base; chemotherapy; chemotherapy induced neuropathy; diabetic; effective therapy; experience; fall risk; falls; instrument; malignant breast neoplasm; neurotoxicity; oxaliplatin; prevent; public health relevance; spatiotemporal; taxane; tool; treatment strategy

DESCRIPTION (provided by applicant): Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting toxicity1 of several commonly used classes of chemotherapy drugs. Peripheral neuropathies have been shown to lead to pain, falls, difficulty in walking and performing activities of daily living in many different populations including the elderly, diabetics, and, caner patients. Based on previous data from other groups of patients with peripheral neuropathies, the central hypothesis of our study is that CIPN results in altered gait and balance, similar to what has been observed in elderly and diabetic populations with peripheral neuropathy. To test our hypothesis, we will first characterize the alterations in gait and balance that occur i breast and colorectal cancer patients during chemotherapy with paclitaxel and oxaliplatin agents. Specifically, we will evaluate (1) spatiotemporal gait parameters, including cadence, step length, and step width, and (2) balance parameters, including time-to-contact and 95% ellipse area, using each patient as his/her own control. Subsequently, we will compare the natural history of changes in gait and balance parameters with changes in CIPN status as measured by validated objective and patient-report instruments including the TNS, EORTC CIPN-20 and BPI that are in commonly used in CIPN research. The long-term goal of our research is to reduce the burden of CIPN on cancer patients' mobility and quality of life. The overall objective of this application is to quantify the natural history o functional deficits that occur due to chemotherapy with oxaliplatin and paclitaxel. Completion of this study will establish the feasibility of evaluating balance and gait parameters as predictors o CIPN. If successful, then this will be an easy to implement and objective assessment of CIPN for future assessment of effectiveness of interventions that help mitigate or perhaps even prevent CIPN in breast and colorectal cancer survivors.

描述（由申请人提供）：化学疗法诱导的周围神经病（CIPN）是几种常用类化疗药物的剂量限制毒性1。周围神经病已被证明会导致疼痛，跌倒，步行和进行日常生活的困难，包括老年人，糖尿病患者和Caner患者。基于其他外周神经病患者组的数据，我们研究的中心假设是CIPN导致步态和平衡改变，类似于在老年人和糖尿病患者中观察到的周围神经病。 为了检验我们的假设，我们将首先描述在乳甲甲酰胺和奥沙利铂剂化学疗法期间，乳腺癌和结直肠癌患者发生的步态和平衡的改变。具体而言，我们将评估（1）时空步态参数，包括节奏，步长和步骤宽度，以及（2）平衡参数，包括接触时间和95％的椭圆形区域，使用每个患者作为他/她自己的控制。随后，我们将比较步态变化和平衡参数的自然历史与CIPN状态的变化，如经过验证的客观和患者报告工具所衡量的，包括TNS，EORTC CIPN-20和BPI，这些工具常用于CIPN研究中。 我们研究的长期目标是减轻CIPN对癌症患者活动能力和生活质量的负担。该应用的总体目的是量化由于阿沙利铂和紫杉醇化学疗法而导致的自然病史O功能缺陷。这项研究的完成将确定评估平衡和步态参数作为预测因素O CIPN的可行性。如果成功，那么这将是对CIPN的易于实施和客观评估，以评估有助于减轻乳腺癌和结直肠癌幸存者中CIPN的干预措施的有效性。