Gait and Balance Changes in Chemotherapy Induced Peripheral Neuropathy

化疗引起的周围神经病变的步态和平衡变化

• 批准号: 8624023
• 负责人: Ajit Mohan Worthen Chaudhari
• 金额: $ 7.69万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8624023
• 关键词: Activities of Daily Living; Affect; Area; Cancer Patient; Cancer Survivor; Colorectal Cancer; Data; Development; Dose-Limiting; Effectiveness; Effectiveness of Interventions; Elderly; Equilibrium; European Organization for Research and Treatment of Cancer; Exercise; Future; Gait; Goals; Incidence; Individual; Intervention; Knowledge; Laboratories; Lead; Length; Life; Malignant Neoplasms; Measures; Metric; Natural History; Nerve; Paclitaxel; Pain; Patient Outcomes Assessments; Patient Self-Report; Patients; Peripheral; Peripheral Nervous System Diseases; Pharmaceutical Preparations; Platinum; Population; Quality of life; Quantitative Evaluations; Relative (related person); Reporting; Research; Risk; Signs and Symptoms; Survivors; Symptoms; Taxane Compound; Testing; Time; Toxic effect; Treatment Effectiveness; Treatment Protocols; Vinca Alkaloids; Walking; Width; Work; base; chemotherapy; chemotherapy induced neuropathy; diabetic; effective therapy; experience; fall risk; falls; instrument; malignant breast neoplasm; neurotoxicity; oxaliplatin; prevent; public health relevance; spatiotemporal; taxane; tool; treatment strategy

DESCRIPTION (provided by applicant): Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting toxicity1 of several commonly used classes of chemotherapy drugs. Peripheral neuropathies have been shown to lead to pain, falls, difficulty in walking and performing activities of daily living in many different populations including the elderly, diabetics, and, caner patients. Based on previous data from other groups of patients with peripheral neuropathies, the central hypothesis of our study is that CIPN results in altered gait and balance, similar to what has been observed in elderly and diabetic populations with peripheral neuropathy. To test our hypothesis, we will first characterize the alterations in gait and balance that occur i breast and colorectal cancer patients during chemotherapy with paclitaxel and oxaliplatin agents. Specifically, we will evaluate (1) spatiotemporal gait parameters, including cadence, step length, and step width, and (2) balance parameters, including time-to-contact and 95% ellipse area, using each patient as his/her own control. Subsequently, we will compare the natural history of changes in gait and balance parameters with changes in CIPN status as measured by validated objective and patient-report instruments including the TNS, EORTC CIPN-20 and BPI that are in commonly used in CIPN research. The long-term goal of our research is to reduce the burden of CIPN on cancer patients' mobility and quality of life. The overall objective of this application is to quantify the natural history o functional deficits that occur due to chemotherapy with oxaliplatin and paclitaxel. Completion of this study will establish the feasibility of evaluating balance and gait parameters as predictors o CIPN. If successful, then this will be an easy to implement and objective assessment of CIPN for future assessment of effectiveness of interventions that help mitigate or perhaps even prevent CIPN in breast and colorectal cancer survivors.

描述（由申请人提供）：化疗引起的周围神经病变（CIPN）是几种常用化疗药物的剂量限制性毒性1。周围神经病变已被证明会导致许多不同人群（包括老年人、糖尿病患者和癌症患者）的疼痛、跌倒、行走和日常生活活动困难。根据之前其他周围神经病变患者组的数据，我们研究的中心假设是 CIPN 会导致步态和平衡改变，类似于在患有周围神经病变的老年人和糖尿病人群中观察到的情况。 为了检验我们的假设，我们将首先描述乳腺癌和结直肠癌患者在接受紫杉醇和奥沙利铂药物化疗期间发生的步态和平衡的变化。具体来说，我们将评估 (1) 时空步态参数，包括步频、步长和步宽，以及 (2) 平衡参数，包括接触时间和 95% 椭圆面积，使用每位患者作为自己的对照。随后，我们将通过经过验证的客观和患者报告仪器（包括 CIPN 研究中常用的 TNS、EORTC CIPN-20 和 BPI）测量，将步态和平衡参数变化的自然史与 CIPN 状态的变化进行比较。 我们研究的长期目标是减轻 CIPN 对癌症患者活动能力和生活质量的负担。该应用的总体目标是量化由于奥沙利铂和紫杉醇化疗而发生的功能缺陷的自然史。这项研究的完成将确定评估平衡和步态参数作为 CIPN 预测因素的可行性。如果成功，那么这将是一个易于实施且客观的 CIPN 评估，用于未来评估有助于减轻甚至预防乳腺癌和结直肠癌幸存者 CIPN 的干预措施的有效性。