Animal Barrier

动物屏障

基本信息

批准号：
9792745
负责人：
LAWRENCE H HERBST
金额：
$ 15.53万
依托单位：
ALBERT EINSTEIN COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9792745
关键词：
Accreditation Adverse event Albert Einstein Cancer Center Alleles Animal Husbandry Animal Technicians Animals Antineoplastic Agents Area Back Biological Assay Biological Testing Biopsy Breeding Cancer Biology Cancer Center Caring Chemicals Clinical Comparative Pathology Complex Consult Consultations Containment Day Care Diagnostic Disease Outbreaks Ensure Environment Equipment Excision Exposure to Faculty Fertility Film Genetic Genotype Gnotobiotic Growth Health Histology Housing Human Human Resources Immune Implant Infection Infectious Agent Institutes Institution Instruction Laboratories Laboratory Animals Longitudinal Studies Malignant Neoplasms Measures Methods Modeling Monitor Morbidity - disease rate Mouse Strains Mus Mutation Neoplasm Metastasis Operative Surgical Procedures Parasites Partner in relationship Pharmaceutical Preparations Phenotype Policies Postdoctoral Fellow Price Problem Solving Procedures Protocols documentation Quarantine Regulation Reporting Research Research Personnel Research Technics Resource Sharing Resources Rodent Scheme Sentinel Services Students Testing Tissue Sample Tissues Training Transgenes Veterinarians angiogenesis animal care animal model selection animal resource anticancer research base flexibility germ free condition hazard member minimally invasive mortality novel operation pathogen programs quality assurance risk minimization tumor tumor xenograft tumorigenesis wasting

项目摘要

PROJECT SUMMARY – ANIMAL BARRIER SHARED RESOURCE The Animal Barrier Shared Resource (ABSR) provides specific pathogen-free (SPF) rodent housing and services that are critical to the research of Albert Einstein Cancer Center (AECC) members and the Center's programmatic activities. The ABSR is a component of the Institute of Animal Studies (IAS), Einstein's AAALAC accredited animal care & use program. The ABSR provides a broad spectrum of animal husbandry services including: veterinary care, comprehensive rodent quality assurance and quarantine programs. There is an intensive program of instruction for AECC members and their trainees prior to allowing access to the facilities to implement matings, genotype progeny, characterize mouse phenotypes, implant tumors and measure their growth, administer drugs, and obtain tissue biopsies. AECC investigators maintain breeding colonies of novel mouse strains bearing transgenes or targeted mutations relevant to cancer biology. Their research also involves complex breeding schemes to recombine specific alleles from different genetic loci into a limited set of genotypes on a single strain background. Many AECC investigators use immune deficient mice that tolerate human tumor xenografts as models to study tumorigenesis, angiogenesis, invasion, and metastasis, as well as to test anti-neoplastic therapies in human cancers. AECC members account for most of the total ABSR usage (cage care-days). The ABSR includes three SPF rodent housing facilities with an overall SPF mouse housing capacity of 25,000 cages. Personnel include three faculty Laboratory Animal Veterinarians (including the Director), an Operations Manager, three Facility Supervisors, four Veterinary Technicians, office staff, and approximately 42 Animal Caretakers.

项目摘要 – 动物屏障共享资源动物屏障共享资源 (ABSR) 提供特定的无病原体 (SPF) 啮齿动物住房和对阿尔伯特·爱因斯坦癌症中心 (AECC) 成员和该中心的研究至关重要的服务 ABSR 是爱因斯坦 AAALAC 动物研究所 (IAS) 的组成部分。经认可的动物护理和使用计划提供广泛的畜牧服务。包括：兽医护理、全面的啮齿动物质量保证和检疫计划。在允许使用设施之前，为 AECC 成员及其学员提供强化教学计划实施交配、对后代进行基因分型、表征小鼠表型、植入肿瘤并测量其 AECC 研究人员维持新菌落的繁殖、给药和组织活检。他们的研究还包括携带与癌症生物学相关的转基因或靶向突变的小鼠品系。涉及复杂的育种计划，将来自不同遗传位点的特定等位基因重组为有限的一组许多 AECC 研究人员使用具有耐受性的免疫缺陷小鼠。人类肿瘤异种移植物作为研究肿瘤发生、血管生成、侵袭和转移的模型，以及 AECC 成员占 ABSR 总使用量的大部分。（笼子护理日）ABSR 包括三个 SPF 啮齿动物饲养设施，以及一个整体 SPF 鼠舍。可容纳 25,000 个笼子，人员包括三名实验动物兽医（包括实验动物兽医）。董事）、一名运营经理、三名设施主管、四名兽医技术员、办公室工作人员和大约 42 名动物管理员。