ShEEP Request for a Perkin Elmer Quantum GX2 Micro CT Imaging System

ShEEP 请求购买 Perkin Elmer Quantum GX2 微型 CT 成像系统

• 批准号: 9795196
• 负责人: Todd A Wyatt
• 金额: --
• 依托单位: OMAHA VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-01 至 2019-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9795196
• 关键词: 3-Dimensional; Advisory Committees; Alcoholic Liver Diseases; Anatomy; Animal Experimentation; Animals; Arthritis; Award; Body Composition; Chronic lung disease; Collaborations; Data Set; Devices; Discipline; Disease; Disease model; Doctor of Philosophy; Dose; Equipment; Fees; Functional disorder; Funding; Goals; Health; Healthcare; High Resolution Computed Tomography; Image; Imaging Device; Laboratory Animals; Longitudinal Studies; Low Dose Radiation; Magnetic Resonance Imaging; Medical center; Minor; Mission; Modality; Modeling; Mus; Nebraska; Performance; Process; Program Evaluation; Radiation; Rattus; Recording of previous events; Request for Applications; Research; Research Infrastructure; Research Personnel; Resolution; Resource Sharing; Resources; Rodent; Scanning; Scientist; Series; Services; Ships; Structure; Structure of parenchyma of lung; Supervision; System; Technology; Therapeutic Intervention; Three-Dimensional Image; Tissue Sample; Tissues; Training; Training and Education; Universities; Veterans; X-Ray Computed Tomography; animal imaging; bone; bone imaging; career; cost; daily functioning; density; experience; flexibility; fluorescence imaging; high resolution imaging; imaging capabilities; imaging study; imaging system; in vivo; instrument; longitudinal analysis; meetings; microCT; morphometry; novel; operation; pre-clinical; quantitative imaging; quantum; reconstruction; side effect; whole body imaging

With this application we request funds from the ORD Shared Equipment Evaluation Program (ShEEP) to purchase a live animal micro CT scanner as a shared resource to be housed in the Research Service of the Omaha VA Medical Center. Specifically, we seek to obtain a Perkin Elmer Quantum GX2 micro CT high-resolution desktop in vivo microtomograph. The Quantum GX2 allows for rapid, high-resolution full body imaging of live rodent species. The Quantum GX2 will provide state-of-the art in vivo live animal imaging capabilities not currently available on the Omaha Veterans Affairs Medical Center (VAMC) campus or its academic Affiliate, the University of Nebraska Medical Center (UNMC). This device will add new capabilities to the existing Omaha VA shared imaging equipment consisting of an IVIS Lumina K Series III system previously purchased by a ShEEP award as well as an Echo MRI imaging system for body composition determinations. As such, the Quantum GX2 micro CT imaging system will significantly enhance the research capabilities of both Omaha VA investigators as well as attract new collaborations with affiliate investigators. The Quantum GX2 is a high performance desktop in vivo micro-CT with variable magnification levels for scanning small laboratory animals as well as ex vivo tissues. This device features high resolution, large image size, both round and helical scanning for reconstruction, and low dose imaging. Because of the large image field of view of the Quantum GX2, full body mouse and rat scanning can be performed. The variable magnification allows scanning bone and tissue samples with high spatial resolution down to 2.3 µm pixel size. A range of filters allows for diverse tissue density applications from lung tissue to bone. Further, the Quantum GX2 in vivo micro CT administers low radiation dose to the animals allowing multiple longitudinal scans without radiation-induced side effects. The Quantum GX2 enables reconstruction of 3D-images and the quantitative calculation of tissue morphometry. Importantly, the Quantum GX2 micro CT scanner is optimized for longitudinal analyses, which is directly applicable to the studies being performed at the OVAMC that are investigating the functional and anatomical basis for diseases that are directly relevant to the mission of the VA. The Quantum GX2 micro CT Imaging System has the flexibility to serve the experimental needs of all the listed participating investigators in this application. This imaging system creates new capability for both the Omaha VAMC as well as our Affiliate University (UNMC), and thus creates new capacity that does not currently exist. The Quantum GX2 will allow for new ways of analyzing our researchers’ existing Veteran-relevant, preclinical disease models, thus promoting the understanding of disease pathophysiology in hopes to advance the therapeutic interventions that will support the mission of the VA in advancing the health care of today’s Veterans.

通过此申请，我们向 ORD 共享设备评估计划请求资金 (ShEEP) 购买一台活体动物微型 CT 扫描仪作为共享资源，放置在 具体来说，我们寻求获得 Perkin Elmer 的奥马哈退伍军人医疗中心研究服务。 Quantum GX2 微型 CT 高分辨率桌面活体显微断层扫描仪 Quantum GX2 可实现。 Quantum GX2 将提供活体啮齿类动物的快速、高分辨率全身成像。 奥马哈退伍军人目前不具备最先进的活体动物体内成像能力 事务医疗中心 (VAMC) 校区或其学术附属机构内布拉斯加大学医学院 该设备将为现有的 Omaha VA 共享成像添加新功能。 包含之前由 ShEEP 奖项购买的 IVIS Lumina K Series III 系统的设备 以及用于确定身体成分的 Echo MRI 成像系统。 GX2微型CT成像系统将显着增强奥马哈VA的研究能力 Quantum GX2 是一个与研究人员合作的平台。 高性能台式活体显微 CT，具有可变放大倍率，可扫描小尺寸 该设备具有高分辨率、大图像尺寸、 圆形和螺旋扫描均可用于重建，并且由于成像剂量大。 Quantum GX2 的图像视野，可以进行小鼠和大鼠的全身扫描。 可变放大倍率允许以高空间分辨率扫描骨骼和组织样本 2.3 µm 像素大小的一系列滤光片可用于从肺组织到组织密度的各种应用。 此外，Quantum GX2 体内微型 CT 对动物的辐射剂量较低。 允许多次纵向扫描，而不会产生辐射引起的副作用。 能够重建 3D 图像并定量计算组织形态测量。 重要的是，Quantum GX2 微型 CT 扫描仪针对纵向分析进行了优化， 直接适用于 OVAMC 正在进行的研究，这些研究正在调查功能性 以及与 VA 使命直接相关的疾病的解剖学基础。 GX2 微型 CT 成像系统可以灵活地满足所有列出的实验需求 该成像系统为参与该应用的研究人员创造了新的功能。 奥马哈 VAMC 以及我们的附属大学 (UNMC)，从而创造了新的能力， 目前尚不存在，Quantum GX2 将提供新的方法来分析我们研究人员的现有数据。 退伍军人相关的临床前疾病模型，从而促进对疾病的理解 病理生理学希望推进治疗干预措施，以支持该组织的使命 VA 致力于促进当今退伍军人的医疗保健。