Administrative Core

行政核心

• 批准号: 9795000
• 负责人: Rima F Kaddurah-Daouk
• 金额: $ 186.56万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-15 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9795000
• 关键词: Adopted; Advisory Committees; Alzheimer disease detection; Alzheimer' s Disease; Alzheimer' s disease related dementia; American; Biological Markers; Brain; Budgets; Chemicals; Clinical; Clinical Trials; Collection; Communication; Communities; Data; Data Analyses; Data Sources; Databases; Dementia; Doctor of Philosophy; Ensure; Funding; Genetic; Goals; Home environment; Informatics; Infrastructure; Internet; Lead; Leadership; Machine Learning; Medicine; Metadata; Metagenomics; Modeling; Neurologist; Occupational activity of managing finances; Pathogenesis; Patient Care; Phenotype; Planet Earth; Protocols documentation; Research; Research Personnel; Resource Allocation; Resources; Role; Running; Sampling; Schedule; Scientist; Site; Specimen; Structure; Technology; Teleconferences; Time; United States National Institutes of Health; Work; biochemical model; clinical research site; data integration; data management; data sharing; deep learning; digital object identifier; experience; gut microbiome; meetings; metabolomics; microbiome; microbiome analysis; multimodality; neuroimaging; neuropsychiatric disorder; operation; programs; relational database; repository; sample collection; success; tool

ABSTRACT – Administrative Core The Admin Core will provide structure and oversight to enable the Alzheimer’s Gut Microbiome Project to achieve its goal to define the gut-brain-chemical axis of communication and the role for the gut microbiome in Alzheimer’s Disease (AD) pathogenesis. This Core is co-led by Duke’s Rima Kaddurah-Daouk, PhD, UCSD’s Robert Knight, PhD, and UCLA’s Sarkis Mazmanian, PhD, who bring considerable leadership experience and complementary scientific expertise to the U19. Dr. Kaddurah-Daouk will serve as contact PI, and brings experience having successfully led four large NIH-funded consortia and is a pioneer in the application of metabolomics in neuropsychiatric diseases, including defining a role for the gut microbiome in AD. Dr. Knight runs the Earth Microbiome Project and American Gut Project and developed microbiome technologies widely used in the field. Dr. Mazmanian discovered a role for the gut microbiome in the pathogenesis of neuropsychiatric diseases. This team is uniquely qualified to lead and coordinate this large program. Three clinical AD experts (Drs. James Brewer, Andrew Saykin, and Murali Doraiswamy) will provide oversight for all clinical activities including samples collection for national AD research centers and flow of samples through the National Centralized Repository for AD and Related Dementias (NCRAD) center. Through its three Aims, the Admin Core will ensure all Projects and Cores function as an efficient, effective, and integrated whole that all components of the U19 have access to the tools and resources necessary to do the proposed work, and that scientific progress is rapid, rigorous, and efficient. This Core will interact with all U19 Projects and Cores through oversight, governance, and management. Main objectives of the Admin core are the integration of data developed by collaborators through the creation of a relational database to manage all data-related activities as well as the creation of a repository of uniformly collected biospecimens at the NCRAD which will be made available to collaborators as well as the greater research community. Through our discussions, this Core will facilitate rigorous oversight of research and data interpretation. Thus this Core’s activities are critical to our collective success.

摘要 - 行政核心 管理员核心将提供结构和监督，以使阿尔茨海默氏症的肠道微生物组项目能够 实现其定义肠道 - 脑化学轴的目标，以及肠道微生物组的作用 阿尔茨海默氏病（AD）发病机理。该核心由Duke的Rima Kaddurah-Daouk（UCSD）共同领导 罗伯特·奈特（Robert Knight）博士和加州大学洛杉矶分校（UCLA）的萨基斯·马兹曼尼亚（Sarkis Mazmanian）博士，他们带来了丰富的领导经验和 U19完全科学专业知识。 Kaddurah-Daouk博士将作为联系PI，并带来 成功领导了四个大型NIH资助的财团的经验，并且是应用的先驱 神经精神疾病中的代谢组学，包括定义肠道微生物组在AD中的作用。奈特博士 运行地球微生物组项目和美国肠道项目，并广泛开发了微生物组技术 在现场使用。 Mazmanian博士发现了肠道微生物组在发病机理中的作用 神经精神疾病。该团队具有领导和协调这一大型计划的独特资格。三 临床广告专家（James Brewer博士，Andrew Saykin和Murali Doraiswamy）将为所有人提供监督 临床活动，包括用于国家广告研究中心的样品收集以及样品流过 广告和相关痴呆症（NCRAD）中心的国家集中式存储库。通过其三个目标， 管理员核心将确保所有项目和核心作为有效，有效和整体的整体作用 U19的组件可以访问进行拟议工作所需的工具和资源，并且 科学进步是快速，严格和高效的。该核心将与所有U19项目和核心互动 通过监督，治理和管理。管理员核心的主要目标是数据的集成 合作者通过创建关系数据库来管理所有与数据相关的活动开发 以及在NCRAD上创建均匀收集的生物测量的存储库 合作者以及更大的研究社区。通过我们的讨论，这个核心将 促进严格的研究和数据解释的监督。这个核心的活动对我们至关重要 集体成功。