Core Grant for Vision Research

视觉研究核心资助

• 批准号: 9795780
• 负责人: W MATTHEW PETROLL
• 金额: $ 64.8万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9795780
• 关键词: Adenoviruses; Area; Award; Basic Science; Biometry; Cell Culture Techniques; Cell Line; Cells; Center Core Grants; Collaborations; Complex; Contract Services; Core Facility; Core Grant; DNA; Data Analyses; Development; Environment; Equipment; Experimental Designs; Faculty; Foundations; Funding; Goals; Institution; Maintenance; Medical Students; Medical center; Molecular Biology; Ophthalmology; Outcome; Phenotype; Postdoctoral Fellow; Privatization; Production; Productivity; Publications; Reproducibility; Research; Research Activity; Research Personnel; Research Project Grants; Resources; Scientist; Services; Structure; Subfamily lentivirinae; Techniques; Time; Tissues; Training; Universities; Validation; Virus; Vision; Vision research; Work; cellular imaging; cost effective; design; digital imaging; equipment training; experience; experimental analysis; graduate student; improved; member; microscopic imaging; novel; operation; programs; quantitative imaging; ranpirnase; recruit; research study; vision development; vision science

Abstract: The overall goal of this NEI Core Center Grant for Vision Research is to enhance the capabilities of vision research scientists by facilitating easy access to equipment, training and technical support which will expand experimental capabilities, result in more cost-effective and time-efficient research, and open up new research directions. This Center will serve vision science researchers across the UT Southwestern Medical Center (UTSW) campus. It will also facilitate new research collaborations and utilization of the core facilities by vision scientists at other nearby institutions. Our proposed NEI Core Center consists of three Resource/Service Modules, each directed by a faculty member with experience and expertise in their unit’s focus area: 1) Cell Culture and Cell Phenotyping (Directed by Dr. Danielle Robertson), which will support the maintenance and authentication of cell lines that are required for rigorous study across a wide range of research activities, and provide equipment and support for quantitative cellular analysis applications; 2) Molecular Biology/Virus Production (Directed by Dr. John Hulleman), which will provide full service DNA production and validation as well as lentivirus and adenovirus production and purification; and, 3) Microscopy and Digital Imaging (Directed by Dr. Matthew Petroll), which will provide equipment, infra-structural support, supplies and technical assistance for quantitative imaging of cells and tissues. In addition, the Center includes a biostatistician who will work with Investigators on the design of their research studies, rigorous analysis of their data, and interpretation of their results. The Specific Aims of the Core Center are to enhance, streamline and add scientific rigor to the research activities of the participating vision scientists by: 1) Supporting the operation of the Resource/Service Modules by managing usage and operations, and providing for skilled technical assistance, equipment maintenance, and the purchase of supplies; 2) providing biostatistical services to Core investigators for the design and analysis of their research studies; 3) expanding the number of collaborative research projects between investigators both within UTSW and between UTSW and other neighboring institutions; 4) creating a more fertile environment for the development of vision research programs of junior faculty members, and for new vision researchers recruited into the University; and, 5) providing resources and training to assist graduate students, medical students, and post-doctoral fellows with their research. Overall, we anticipate that the Core Grant for Vision Research will impact the research programs of these researchers by allowing them to: 1) expand into new research areas through the addition of novel experimental techniques; 2) develop new collaborations with other Core Center users throughout the region; 3) improve their productivity and efficiency through the use of Core services; and, 4) optimize their experimental design and analysis to maintain a high level of rigor and reproducibility.

抽象的： 这项NEI核心中心赠款的总体目标是增强视觉的能力 研究科学家通过支持轻松获得设备，培训和技术支持，这将扩大 实验能力，导致更具成本效益和时间效率的研究，并开放新的研究 方向。该中心将为UT西南医学中心的视觉科学研究人员提供服务 （UTSW）校园。它还将促进远见的新研究合作和核心设施的利用 附近其他机构的科学家。 我们提议的NEI核心中心由三个资源/服务模块组成，每个模块由教师执导 在其单位的重点领域具有经验和专业知识的成员：1）细胞培养和细胞表型（定向 丹妮尔·罗伯逊（Danielle Robertson）博士），该博士将支持细胞系的维护和身份验证 在广泛的研究活动中进行严格研究所必需的，并为 定量细胞分析应用； 2）分子生物学/病毒的产生（约翰博士指导 船体），它将提供全方位服务的DNA生产和验证以及慢病毒和腺病毒病毒 生产和纯化； 3）显微镜和数字成像（由Matthew Petroll博士执导），这是 将提供设备，基础设施支持，供应和技术援助，以定量成像 细胞和组织。此外，该中心还包括一个生物统计学家，他将与调查人员合作 他们的研究研究，对数据的严格分析以及对结果的解释。 核心中心的具体目的是增强，简化和增加科学严格的研究 参与愿景科学家的活动：1）支持资源/服务模块的运行 通过管理使用和操作，并提供熟练的技术援助，设备维护， 以及购买用品； 2）为设计核心调查人员提供生物统计学服务，并 他们的研究分析； 3）扩大之间的协作研究数量 UTSW和UTSW和其他邻近机构之间的调查人员； 4）创建更多 为制定初级教师的视觉研究计划的肥沃环境，并为新的 视力研究人员招募了大学； 5）提供资源和培训以协助毕业生 学生，医学生和博士后研究员的研究。 总体而言，我们预计视力研究的核心赠款将影响其中的研究计划 通过允许研究人员：1）通过添加新颖的实验性扩展到新的研究领域 技术； 2）与整个地区的其他核心中心用户开发新的合作； 3）改善它们 通过使用核心服务来生产力和效率； 4）优化其实验设计和 分析以保持高水平的严格和繁殖。