Shape Memory Polymer Devices for Treating Stroke

用于治疗中风的形状记忆聚合物装置

• 批准号: 8265897
• 负责人: DUNCAN J MAITLAND
• 金额: $ 104.85万
• 依托单位: TEXAS ENGINEERING EXPERIMENT STATION
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-03 至 2014-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8265897
• 关键词: Acute; Address; Alloys; Anatomy; Aneurysm; Angiography; Animal Model; Animals; Award; Binding; Blood Vessels; Brain hemorrhage; Catheters; Cerebrum; Clinic; Clinical; Clinical Trials; Coagulation Process; Complex; Development; Device Designs; Devices; Electronics; Endothelial Cells; Family suidae; Foundations; Funding; Generations; Goals; Heating; Human; Hybrids; Image; Implant; Industry; Internet; Ischemic Stroke; Liquid substance; Mechanics; Medical; Medical Technology; Medical center; Medicine; Memory; Modeling; Modification; Optics; Polymer Chemistry; Polymers; Polyurethanes; Positioning Attribute; Process; Progress Reports; Property; Publications; Recovery; Research; Research Personnel; Science; Shapes; Staging; Stents; Stress; Stroke; Stroke prevention; Surface; System; Techniques; Technology; Testing; Therapeutic; Thrombectomy; Thrombus; Time; Training; Ursidae Family; Water; Work; base; biomaterial compatibility; computerized tools; cost; design; experience; flexibility; follow-up; implantable device; improved; in vivo; multidisciplinary; novel; polydimethylsiloxane; programs; prototype; research study

We propose to develop shape memory polymer (SMP) interventional devices for treating stroke victims that currently have limited therapeutic alternatives (450,000/yr in the USA). The development and testing of two complementary devices is proposed: a foam for filling aneurysms and a mechanical clot extraction system. The foam will address a major cause of hemorrhagic strokes. The clot extraction system will address the current clinical need for an acute ischemic stroke treatment and is a second generation device based on the results from our initial funding period. The foundation of this proposal is the multidisciplinary team and the existing partnership that exists between the Medical Technology Program at LLNL and UC Davis Medical Center (UCD). The team is comprised of the four co-Pis: Duncan Maitland (LLNL), Thomas Wilson (LLNL), Judy Van de Water (UCD) and Jonathan Hartman (UCD). During our first four years of the initial BRP award we have demonstrated significant results that strengthen our original hypothesis that these relatively new materials will make possible novel and clinically feasible mechanical devices for treating/preventing stroke. Key developments during the first award period are the enabling cornerstones of the current proposal: novel SMP polyurethanes with improved thermomechanical, optical and biocompatibility properties; SMP foams; successful animal model and biocompatibility studies; multi-stage 3D fabrication techniques; and a large body of analytical, experimental and computational tools brought to bear on material properties and device-body interactions. At the end of a second five-year term of support we will be in a position to pursue commercial support for transferring the devices/technology to industry and, through this process, into the clinic.

我们建议开发形状记忆聚合物（SMP）介入装置来治疗中风患者 目前的治疗替代方案有限（美国每年 450,000 种）。两个的开发和测试 提出了补充装置：用于填充动脉瘤的泡沫和机械血栓提取系统。 该泡沫将解决出血性中风的主要原因。凝块提取系统将解决 当前临床需要急性缺血性中风治疗，是基于 我们最初的资助期的结果。 该提案的基础是多学科团队以及之间存在的现有伙伴关系 LLNL 和加州大学戴维斯分校医学中心 (UCD) 的医疗技术项目。该团队由以下人员组成 四位联合督导：Duncan Maitland (LLNL)、Thomas Wilson (LLNL)、Judy Van de Water (UCD) 和 Jonathan 哈特曼（UCD）。在最初授予 BRP 的头四年里，我们取得了显着的成果 这加强了我们最初的假设，即这些相对较新的材料将使新颖和 用于治疗/预防中风的临床上可行的机械装置。首届颁奖期间的主要进展 周期是当前提案的有利基石：具有改进的新型SMP聚氨酯 热机械、光学和生物相容性； SMP 泡沫；成功的动物模型和 生物相容性研究；多阶段 3D 制造技术；以及大量的分析、实验 以及对材料特性和设备与身体相互作用产生影响的计算工具。 在第二个五年支持期结束时，我们将能够寻求商业支持 将设备/技术转移到工业界，并通过这个过程转移到诊所。

项目成果

A Processable Shape Memory Polymer System for Biomedical Applications.

• DOI: 10.1002/adhm.201500156
• 发表时间: 2015-06-24
• 期刊: Advanced healthcare materials
• 影响因子: 10
• 作者: Hearon K;Wierzbicki MA;Nash LD;Landsman TL;Laramy C;Lonnecker AT;Gibbons MC;Ur S;Cardinal KO;Wilson TS;Wooley KL;Maitland DJ
• 通讯作者: Maitland DJ

A shape memory foam composite with enhanced fluid uptake and bactericidal properties as a hemostatic agent.

• DOI: 10.1016/j.actbio.2016.10.008
• 发表时间: 2017-01-01
• 期刊: Acta biomaterialia
• 影响因子: 9.7
• 作者: Landsman TL;Touchet T;Hasan SM;Smith C;Russell B;Rivera J;Maitland DJ;Cosgriff-Hernandez E
• 通讯作者: Cosgriff-Hernandez E

Virtual treatment of basilar aneurysms using shape memory polymer foam.

• DOI: 10.1007/s10439-012-0719-9
• 发表时间: 2013-04
• 期刊: ANNALS OF BIOMEDICAL ENGINEERING
• 影响因子: 3.8
• 作者: Ortega, J. M.;Hartman, J.;Rodriguez, J. N.;Maitland, D. J.
• 通讯作者: Maitland, D. J.

Triple-Shape Memory Polymers Based on Self-Complementary Hydrogen Bonding.

• DOI: 10.1021/ma202098s
• 发表时间: 2012-01-06
• 期刊: Macromolecules
• 影响因子: 5.5
• 作者: Ware T;Hearon K;Lonnecker A;Wooley KL;Maitland DJ;Voit W
• 通讯作者: Voit W

The effect of free radical inhibitor on the sensitized radiation crosslinking and thermal processing stabilization of polyurethane shape memory polymers.

• DOI: 10.1016/j.radphyschem.2012.10.007
• 发表时间: 2013-02
• 期刊: Radiation physics and chemistry (Oxford, England : 1993)
• 作者: Hearon K;Smith SE;Maher CA;Wilson TS;Maitland DJ
• 通讯作者: Maitland DJ