Shape Memory Polymer Devices for Treating Stroke

用于治疗中风的形状记忆聚合物装置

• 批准号: 8037721
• 负责人: DUNCAN J MAITLAND
• 金额: $ 107.54万
• 依托单位: TEXAS ENGINEERING EXPERIMENT STATION
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-03 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8037721
• 关键词: Acute; Address; Alloys; Anatomy; Aneurysm; Angiography; Animal Model; Animals; Award; Binding; Blood Vessels; Brain hemorrhage; Catheters; Cerebrum; Clinic; Clinical; Clinical Trials; Coagulation Process; Complex; Development; Device Designs; Devices; Electronics; Endothelial Cells; Family suidae; Foundations; Funding; Generations; Goals; Heating; Human; Hybrids; Image; Implant; Industry; Internet; Ischemic Stroke; Liquid substance; Mechanics; Medical; Medical Technology; Medical center; Medicine; Memory; Modeling; Modification; Optics; Polymer Chemistry; Polymers; Polyurethanes; Positioning Attribute; Process; Progress Reports; Property; Publications; Recovery; Research; Research Personnel; Science; Shapes; Staging; Stents; Stress; Stroke; Stroke prevention; Surface; System; Techniques; Technology; Testing; Therapeutic; Thrombectomy; Thrombus; Time; Training; Ursidae Family; Water; Work; base; biomaterial compatibility; computerized tools; cost; design; experience; flexibility; follow-up; implantable device; improved; in vivo; multidisciplinary; novel; polydimethylsiloxane; programs; prototype; research study

We propose to develop shape memory polymer (SMP) interventional devices for treating stroke victims that currently have limited therapeutic alternatives (450,000/yr in the USA). The development and testing of two complementary devices is proposed: a foam for filling aneurysms and a mechanical clot extraction system. The foam will address a major cause of hemorrhagic strokes. The clot extraction system will address the current clinical need for an acute ischemic stroke treatment and is a second generation device based on the results from our initial funding period. The foundation of this proposal is the multidisciplinary team and the existing partnership that exists between the Medical Technology Program at LLNL and UC Davis Medical Center (UCD). The team is comprised of the four co-Pis: Duncan Maitland (LLNL), Thomas Wilson (LLNL), Judy Van de Water (UCD) and Jonathan Hartman (UCD). During our first four years of the initial BRP award we have demonstrated significant results that strengthen our original hypothesis that these relatively new materials will make possible novel and clinically feasible mechanical devices for treating/preventing stroke. Key developments during the first award period are the enabling cornerstones of the current proposal: novel SMP polyurethanes with improved thermomechanical, optical and biocompatibility properties; SMP foams; successful animal model and biocompatibility studies; multi-stage 3D fabrication techniques; and a large body of analytical, experimental and computational tools brought to bear on material properties and device-body interactions. At the end of a second five-year term of support we will be in a position to pursue commercial support for transferring the devices/technology to industry and, through this process, into the clinic.

我们建议开发形状记忆聚合物（SMP）介入的介入设备，以治疗中风受害者 目前的治疗方法有限（美国为450,000/年）。两个的开发和测试 提出了补充设备：用于填充动脉瘤和机械凝块提取系统的泡沫。 泡沫将解决出血性中风的主要原因。凝块提取系统将解决 当前对急性缺血性中风治疗的临床需求，是基于 最初资金期的结果。 该提案的基础是多学科团队和现有的合作伙伴关系 LLNL和UC Davis医疗中心（UCD）的医疗技术计划。该团队由 四个共同提议：邓肯·梅特兰（LLNL），托马斯·威尔逊（LLNL），朱迪·范·德·沃特（UCD）和乔纳森 哈特曼（UCD）。在首次BRP奖的头四年中，我们显示了重大的结果 这加强了我们最初的假设，即这些相对较新的材料将使新颖的新颖材料和 用于治疗/预防中风的临床上可行的机械设备。第一奖的关键发展 期间是当前建议的启示基石：新型SMP聚氨酯，改进了 热机械，光学和生物相容性特性； SMP泡沫；成功的动物模型和 生物相容性研究；多阶段3D制造技术；还有大量的分析，实验性 以及为材料属性和设备体相互作用带来的计算工具。 在第二个五年的支持期结束时，我们将有能力寻求商业支持 将设备/技术转移到行业，并通过此过程将设备/技术转移到诊所中。