Breast CT scanner for earlier cancer detection

用于早期癌症检测的乳房 CT 扫描仪

• 批准号: 8269559
• 负责人: JOHN M BOONE
• 金额: $ 102.32万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8269559
• 关键词: 3-Dimensional; Ablation; Algorithms; Area; Beds; Biomedical Engineering; Biopsy; Breast; Breast Cancer Detection; Breast Cancer Treatment; Burn injury; Calibration; California; Chicago; Clinical; Clinical Research; Clinical Trials; Computer Assisted; Computer software; Computer-Assisted Diagnosis; Computers; Contrast Media; Data; Data Set; Databases; Descriptor; Detection; Development; Devices; Diagnosis; Diagnostic; Diagnostic Imaging; Diagnostic Procedure; Digital Mammography; Dose; Electronics; Environment; Evaluation; Fluoroscopy; Funding; Goals; Gold; Gray unit of radiation dose; Hand; Human; Image; Imagery; Imaging Techniques; Imaging technology; Immobilization; Industry; Injection of therapeutic agent; Isotopes; Kinetics; Left; Lesion; Logic; Magnetic Resonance Imaging; Malignant Neoplasms; Mammary Neoplasms; Mammography; Manufacturer Name; Markov Chains; Measurement; Measures; Mechanics; Medicine; Methodology; Methods; Modeling; Names; Needle biopsy procedure; Needles; Noise; PET/CT scan; Pain; Paper; Patients; Peer Review; Performance; Perfusion; Phase; Phase I Clinical Trials; Phase II Clinical Trials; Physicians; Physiologic pulse; Positioning Attribute; Positron-Emission Tomography; Procedures; Process; Productivity; Property; Psychophysiology; Radiation; Radiofrequency Interstitial Ablation; Relative (related person); Research; Research Activity; Research Personnel; Resolution; Resources; Retinal Cone; Robot; Robotics; Roentgen Rays; Rotation; Safety; Sampling; Scanning; Screening for cancer; Screening procedure; Shapes; Site; Skin; Slice; Spiculate; Structure; System; Techniques; Technology; Testing; Texture; Therapeutic procedure; Thick; Three-Dimensional Image; Time; Tissues; Tracer; Translating; Translations; Tube; Ultrasonography; Universities; Water; Woman; Work; X-Ray Computed Tomography; abstracting; analytical tool; arm; base; breast density; breast lesion; case-by-case basis; clinical care; computer aided detection; computerized; design; detector; digital computing; dosimetry; fluorodeoxyglucose positron emission tomography; improved; malignant breast neoplasm; mechanical drive; minimally invasive; novel diagnostics; operation; patient safety; prevent; programs; prototype; reconstruction; research clinical testing; research study; response; simulation; success; technology development; tomography; tool; treatment planning; treatment strategy; tumor; two-dimensional; whole body imaging

DESCRIPTION (provided by applicant): This is a competitive renewal application for a bioengineering research partnership (BRP) on breast CT. Over the past 4.3 years, we have developed two breast CT scanners and were the first group to demonstrate the performance of cone beam breast CT in patients, with 94 patients imaged as of January 2007. We also developed the methodology for accurate dose assessment in the pendant breast CT geometry, and have unambiguously shown that excellent quality breast CT images can be produced at radiation levels equal to two view mammography. Good productivity has been achieved in the aims of the previous funding period, with 12 trainees, 14 peer reviewed papers, 11 other papers, 2 chapters, 15 abstracts and 21 invited presentations. In this proposal, we seek to significantly extend the clinical utility of the basic breast CT platform through further technical development combined with clinical evaluation. A new breast CT scanner will be designed and fabricated, utilizing the basic framework of an existing scanner but incorporating a slip ring, pulsed x-rays, and helical acquisition; the system will allow thick fan beam helical scanning for normal operation and cone beam breast imaging for studies using contrast agent injection. In addition to developing new diagnostic imaging modes including contrast kinetic curve assessment, tomosynthesis, breast PET/CT and magnification-mode breast CT, theoretical and numerical analysis methods such as ideal observer assessment and computer aided diagnosis methods are proposed to better understand the fundamental diagnostic potential of breast tomography. We propose further hardware development on the bCT platform so that it will serve as a multifunctional breast cancer analysis and treatment tool, allowing minimally invasive image guided treatment regimes for breast cancer, including robotically guided breast biopsy, radiofrequency ablation, and x-ray ablation. The research plan describes 16 aims in four phases of development (1) new hardware development, (2) analytical tools for improving interpretation and diagnosis, (3) technology development for image guided assessment and treatment of breast cancer, and (4) clinical trials in breast CT diagnosis and treatment. Two nearly identical breast CT scanners will be fabricated and sited at UC Davis and UC San Diego, and patient accrual at two sites will enable the study of over 800 patients, with many cross comparisons. Non-invasive imaging will proceed in Phase II clinical trials, while the minimally invasive studies will be performed in smaller Phase I trials. At the end of this program of research and discovery, breast CT will likely be shown to be a key clinical tool for the diagnosis and treatment of breast cancer.

描述（由申请人提供）：这是在乳腺CT上建立生物工程研究合作伙伴关系（BRP）的竞争更新申请。在过去的4。3年中，我们已经开发了两种乳房CT扫描仪，并且是第一个证明患者锥束乳房CT表现的组，截至2007年1月，有94例患者成像。我们还开发了用于准确剂量评估的方法论，在吊体乳房CT几何形状中进行准确的剂量评估，并明确地证明了优秀的质量乳房CT图像可以在Hardiation Perviatiation Periviation Perviation Chiep Periviation Chieviation Pervie vise viev View tavie View tevie View Mive Prokectial中产生。在上一期融资期的目标中，已经实现了良好的生产率，有12名受训者，14个同行评审的论文，其他11篇论文，2章，15个摘要和21个受邀演讲。在此提案中，我们试图通过进一步的技术开发以及临床评估来显着扩展基本乳腺CT平台的临床实用性。将使用现有扫描仪的基本框架进行设计和制造新的乳房CT扫描仪，但结合了滑环，脉冲X射线和螺旋式采集；该系统将允许使用造影剂注入的厚风扇梁螺旋扫描以进行正常操作，并使用对比剂注射进行研究。除了开发新的诊断成像模式外，包括对比动力学曲线评估，延迟合成，母乳/CT和放大倍率模式乳腺CT，理论和数值分析方法，例如理想的观察者评估和计算机辅助诊断方法，以更好地了解乳房整体术的基本诊断潜力。我们在BCT平台上提出了进一步的硬件开发，以便它可以作为多功能乳腺癌分析和治疗工具，从而使乳腺癌的最低侵入性图像指导性治疗方案，包括机器人引导的乳房活检，射频消融和X射线消融。研究计划描述了16个旨在在四个阶段（1）新硬件开发，（2）改善解释和诊断的分析工具，（3）图像指导性评估和治疗乳腺癌的技术开发，以及（4）乳腺CT诊断和治疗中的临床试验。将在加州大学戴维斯分校和加州大学圣地亚哥分校制造和位置两个几乎相同的乳房CT扫描仪，并且在两个部位的患者应计入将使800多名患者进行研究，并进行许多交叉比较。非侵入性成像将在II期临床试验中进行，而微创研究将在较小的I期试验中进行。在该研究与发现计划的结尾，乳腺CT可能被证明是诊断和治疗乳腺癌的关键临床工具。

项目成果

Mean glandular dose coefficients (D(g)N) for x-ray spectra used in contemporary breast imaging systems.

• DOI: 10.1088/0031-9155/60/18/7179
• 发表时间: 2015-09-21
• 期刊: Physics in medicine and biology
• 影响因子: 3.5
• 作者: Nosratieh A;Hernandez A;Shen SZ;Yaffe MJ;Seibert JA;Boone JM
• 通讯作者: Boone JM

Evaluation of non-Gaussian statistical properties in virtual breast phantoms.

虚拟乳房模型中非高斯统计特性的评估。

• DOI: 10.1117/1.jmi.6.2.025502
• 发表时间: 2019
• 期刊: Journal of medical imaging (Bellingham, Wash.)
• 作者: Abbey,CraigK;Bakic,PredragR;Pokrajac,DavidD;Maidment,AndrewDA;Eckstein,MiguelP;Boone,JohnM
• 通讯作者: Boone,JohnM

Persistent CT nephrograms following cardiac catheterisation and intervention: initial observations.

• DOI: 10.1007/s13244-011-0131-2
• 发表时间: 2012-02
• 期刊: INSIGHTS INTO IMAGING
• 影响因子: 4.7
• 作者: Katzberg, Richard W;Monsky, Wayne L;Prionas, Nicolas D;Sidhar, Vishal;Southard, Jeffrey;Carlson, Janine;Boone, John M;Lin, Tzu-Chun;Li, Chin-Shang
• 通讯作者: Li, Chin-Shang

Studies of a prototype linear stationary x-ray source for tomosynthesis imaging.

• DOI: 10.1088/0031-9155/59/10/2393
• 发表时间: 2014-05-21
• 期刊: Physics in medicine and biology
• 影响因子: 3.5
• 作者: Schwoebel PR;Boone JM;Shao J
• 通讯作者: Shao J

An X-Ray computed tomography/positron emission tomography system designed specifically for breast imaging.

• DOI: 10.1177/153303461000900104
• 发表时间: 2010-02
• 期刊: Technology in cancer research & treatment
• 影响因子: 2.8
• 作者: Boone JM;Yang K;Burkett GW;Packard NJ;Huang SY;Bowen S;Badawi RD;Lindfors KK
• 通讯作者: Lindfors KK