Ang II-Induced Hypertension: Role of Ac-SDKP in End Organ Damage

Ang II 诱发的高血压：Ac-SDKP 在终末器官损伤中的作用

• 批准号: 7727794
• 负责人: Oscar A. Carretero
• 金额: $ 41.32万
• 依托单位: HENRY FORD HEALTH SYSTEM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7727794
• 关键词: AGTR2 gene; Albuminuria; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents; Anti-inflammatory; Antioxidants; Aorta; Arteries; Arts; Attenuated; Biostatistics Core; Blood Circulation; Blood Pressure; Blood Vessels; Bone Marrow Stem Cell; Cardiac; Cardiovascular system; Carotid Arteries; Cell Adhesion Molecules; Cell Proliferation; Cells; Chronic Kidney Failure; Collagen; Complement; Core Facility; Development; Diabetes Mellitus; Dinoprostone; Doctor of Medicine; Doctor of Philosophy; EP4 receptor; Elasticity; Endocrine; Epithelial Cells; Equilibrium; Fibroblasts; Fibrosis; Functional disorder; Galectin 3; Generations; Growth; Heart Diseases; Heart Hypertrophy; Heart failure; Hormones; Hydrolysis; Hypertension; Hypertrophy; ITGAM gene; Immune; In Vitro; Infiltration; Inflammation; Inflammatory; Infusion procedures; Kidney; Kidney Diseases; Kinins; Macrophage Activation; Mediating; Mediation; Microcirculation; Modeling; Molecular; Monoclonal Antibodies; Mus; Mutant Strains Mice; Myocardial Infarction; Myofibroblast; Natriuretic Factors; Nephrectomy; Nephrons; Organ; PTGS2 gene; Peptidyl-Dipeptidase A; Pericardial body location; Peripheral; Peripheral Vascular Diseases; Physiological; Play; Pore Proteins; Principal Investigator; Proteinuria; Rattus; Regulation; Renal function; Research Personnel; Resistance; Risk Factors; Role; Signal Transduction; Sodium; Sodium Chloride; Stem cells; Stroke; System; Testing; Therapeutic Effect; Type 2 Angiotensin II Receptor; Vasodilation; Vasodilation disorder; Water; Wild Type Mouse; Yang; absorption; abstracting; arteriole; autocrine; concept; connective tissue growth factor; cytokine; glomerulosclerosis; goralatide; improved; in vivo; inhibitor/antagonist; interstitial; kidney vascular structure; macrophage; mesangial cell; migration; monocyte; nephrin; novel; oxidation; paracrine; pressure; prevent; programs; protective effect; receptor; transcription factor

Principal Investigator/Program Director (Last, First, Middle): CaiTeterO, Oscar A., M.D. PROJECT I Ang ll-lnduced Hypertension: Role of Ac-SDKP in End Organ Damage Principal Investigator: Oscar A. Carretero, M.D. Co-Investigator: Nour-Eddine Rhaleb, Ph.D. Co-Investigator: Xiao-Ping Yang, M.D. Co-Investigator: Pamela Harding, Ph.D. Co-Investigator: Patrick Pagano, Ph.D. Co-Investigator: Yun-He Liu, M.D. Abstract Hypertension is a major risk factor for myocardial infarction, stroke, peripheral vascular disease, heart failure and chronic renal disease. Angiotensin II (Ang II) plays a

首席研究员/项目总监（最后，第一，中间）：CaiTeterO，Oscar A.，M.D. 项目一 血管紧张素诱导的高血压：Ac-SDKP 在终末器官损伤中的作用 首席研究员：Oscar A. Carretero，医学博士 联合研究员：Nour-Eddine Rhaleb 博士 联合研究员：杨小平，医学博士 联合研究员：帕梅拉·哈丁博士 联合研究员：帕特里克·帕加诺博士 联合研究员：刘云鹤，医学博士 抽象的 高血压是心肌梗塞、中风、周围血管疾病、心力衰竭的主要危险因素 和慢性肾脏疾病。血管紧张素 II (Ang II) 发挥着