Hyperpolarized MRI Technology Resource Center

超极化 MRI 技术资源中心

• 批准号: 8305991
• 负责人: Daniel B Vigneron
• 金额: $ 104.87万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8305991
• 关键词: Biochemical Pathway; Biological Process; Chemicals; Clinic; Clinical; Communities; Computer software; Custom; Data; Detection; Development; Extramural Activities; Feedback; Funding; Goals; Health; Image; Imaging Techniques; In Vitro; Label; Magnetic Resonance Imaging; Metabolic; Methods; Monitor; Nuclear; Patient Care; Reporting; Research; Research Personnel; Resources; Scientist; Services; Signal Transduction; Site; Solutions; Techniques; Technology; Training; Translating; Universities; experience; human disease; imaging modality; improved; in vivo; instrument; instrumentation; interest; molecular imaging; open source; pre-clinical research; prototype; reconstruction; research and development; spectroscopic imaging; symposium; technology development; uptake; web site

DESCRIPTION: (provided by applicant): Hyperpolarized MRI using Dynamic Nuclear Polarization (DNP) is a powerful new imaging technique which uses specialized instrumentation to provide signal enhancements of over 5-orders of magnitude for 13C enriched compounds. The resulting hyperpolarized solution then can be injected in a MR scanner to detect not only the uptake of the targeted molecule but also its metabolic products in vivo using rapid 13C MR acquisitions. Since hyperpolarized 13C MR spectroscopic imaging encodes chemical as well as spatial information, this new molecular imaging technique allows the simultaneous detection of multiple biologic compounds and metabolic products. This extraordinary new technique has the potential to become a major new MR metabolic imaging technique by providing valuable new information on previously-inaccessible aspects of biological processes by detecting endogenous, nontoxic 13C-labeled probes that can monitor enzymatic conversions through key biochemical pathways. Hyperpolarized 13C MR has generated great interest in the imaging community and is becoming increasingly widespread with Oxford Instruments recently reporting that they have sold 37 commercial HyperSense DNP polarizers of which 10 are focused on in vitro studies and 27 for in vivo studies (since the first installed in 2006 at UCSF). There are an additional 5+ prototype, custom-built DNP polarizers being used in university preclinical research, bringing the total to ~30 sites thus far. With the increasing interest and number of DNP polarizers, we feel it is timely and beneficial to this emerging field to establish a Hyperpolarized MRI Technology Resource Center to develop, investigate, and disseminate new hyperpolarized MR techniques, new 13C agents and specialized analysis open-source software for data reconstruction and interpretation. The Technology Research & Development projects will leverage the extensive DNP facilities and experience of the project leaders to develop improved, robust hyperpolarized MRI methods. These technology developments will be driven by Collaborative Projects led by outstanding clinical and basic scientists who aim to use hyperpolarized 13C MRI to accomplish the scientific goals of their funded research. These technical developments will also be disseminated to the Service Project investigators for extramural feedback and then widely to the scientific community via a dedicated website and onsite training. This center will provide state-of-the-art training in this new metabolic imaging field and sponsor a yearly symposium focused on hyperpolarized MR technology development.

描述：（由申请人提供）：使用动态核极化（DNP）的超极化 MRI 是一种强大的新型成像技术，它使用专用仪器为 13C 富集化合物提供超过 5 个数量级的信号增强。然后可以将所得的超极化溶液注射到 MR 扫描仪中，使用快速 13C MR 采集不仅可以检测目标分子的摄取，还可以检测其体内代谢产物。由于超极化 13C MR 光谱成像编码化学和空间信息，因此这种新的分子成像技术可以同时检测多种生物化合物和代谢产物。这项非凡的新技术有潜力成为一种重要的新型 MR 代谢成像技术，通过检测可通过关键生化途径监测酶转化的内源性、无毒 13C 标记探针，提供有关生物过程以前无法获得的方面的有价值的新信息。超极化 13C MR 引起了成像界的极大兴趣，并且变得越来越广泛，牛津仪器最近报告称，他们已售出 37 个商用 HyperSense DNP 偏振器，其中 10 个专注于体外研究，27 个用于体内研究（自首次安装以来） 2006 年在加州大学旧金山分校 (UCSF)。还有另外 5 个以上的原型、定制 DNP 偏振器正在大学临床前研究中使用，到目前为止总数已达到约 30 个。随着 DNP 偏振器的兴趣和数量不断增加，我们认为建立超偏振 MRI 技术资源中心来开发、研究和传播新的超偏振 MR 技术、新的 13C 试剂和专业分析开源是及时且有益的用于数据重建和解释的软件。技术研发项目将利用广泛的 DNP 设施和项目负责人的经验来开发改进的、稳健的超极化 MRI 方法。这些技术的发展将由杰出的临床和基础科学家领导的合作项目推动，他们的目标是使用超极化 13C MRI 来实现其资助研究的科学目标。这些技术进展还将传播给服务项目研究人员以获得外部反馈，然后通过专门的网站和现场培训广泛传播给科学界。该中心将在这一新的代谢成像领域提供最先进的培训，并主办每年一度的专注于超极化 MR 技术开发的研讨会。