Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry

多供应商多站点新型加速 MRI 松弛测量

• 批准号: 10861563
• 负责人: Xiaojuan Li
• 金额: $ 30.59万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-15 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10861563
• 关键词: Acceleration; Acute; Affect; Age; Area; Body mass index; Brain; Caring; Cartilage; Chronic; Clinical; Coupled; Data; Degenerative polyarthritis; Disease; Economic Burden; Evaluation; Functional Magnetic Resonance Imaging; Future; Goals; Health Care Costs; High Prevalence; Image; Imaging technology; Immune system; Impairment; Injury; Investigation; Joints; Knee; Knee Injuries; Knee Osteoarthritis; Knee joint; Magnetic Resonance Imaging; Maps; Methods; Modeling; Morbidity - disease rate; Musculoskeletal Diseases; Musculoskeletal Pain; National Institute of Arthritis, and Musculoskeletal, and Skin Diseases; Nature; Nervous System; Neuropathy; Nociception; Nociceptors; Onset of illness; Operative Surgical Procedures; Orthopedics; Outcome; Outcome Study; Pain; Pain Research; Pain management; Parents; Pathogenicity; Patient Outcomes Assessments; Patients; Pattern; Persons; Play; Population; Prevalence; Process; Quality of life; Questionnaires; Replacement Arthroplasty; Reporting; Resources; Role; Site; Structure; Symptoms; System; Techniques; Time; Tissues; Traumatic Arthropathy; Vendor; Visit; Work; anterior cruciate ligament injury; anterior cruciate ligament reconstruction; anterior cruciate ligament rupture; arthropathies; biomarker identification; brain magnetic resonance imaging; cohort; cost; disability; experience; health economics; high risk; imaging biomarker; imaging study; improved; infancy; innovation; insight; interest; joint injury; knee pain; multimodality; neural; neuroimaging; neuromechanism; new therapeutic target; novel; novel imaging technique; novel therapeutic intervention; opioid epidemic; osteoarthritis pain; pain relief; painful neuropathy; patient population; persistent symptom; predictive marker; prescription opioid; radiomics; sex; socioeconomics

PROJECT SUMMARY/ABSTRACT This urgent competitive revision responds to NIAMS Notice of Special Interest (NOSI) NOT-AR-23-015. The parent study (NIAMS R01 AR077452) aims to develop novel quantitative MRI techniques (accelerated MR T1ρ and T2 mapping) to evaluate cartilage compositional changes and early degeneration in patients after anterior cruciate ligament reconstruction (ACLR), a population at high risk of developing post-traumatic osteoarthritis (PTOA). In this study, we aim to explore the mechanisms in musculoskeletal (MSK) pain and identify novel imaging (knee and brain) markers for pain after ACL injury and surgery, and at early PTOA. The proposed study will significantly expand the scope of the parent study from only focusing on structural changes (‘disease’) to one evaluating patient symptoms (‘illness’, in particular pain) in OA. With a novel multi-modal approach that includes advanced knee and brain MRI, our group will, for the first time, investigate central neural system (CNS) alterations in pain post orthopaedic injury/surgery, and in early PTOA. The study outcomes will provide critical preliminary data to formulate specific hypotheses for MSK pain, and will develop novel imaging techniques that can be utilized for future large-scale studies of pain mechanisms following orthopaedic injury/surgery and in OA/PTOA, an under-investigated area with pressing clinical needs. As such, the proposed study is aligned with the NOSI Goal A: Generate supporting evidence towards a future innovative study or new scientific direction in pain research in musculoskeletal diseases, in the areas of interest of novel pain imaging technologies. OA affects 30+ million people in the US and 300+ million people worldwide. It presents tremendous health and socioeconomic burdens with health care costs and work loss. Pain is the major factor that significantly impairs quality of life, leads to disability, and prompts patients for clinical visits and eventually total joint arthroplasty for OA. Opioid prescriptions for severe OA/PTOA pain and pain after orthopaedic injury are common, which constitutes a significant contribution to the national opioid crisis due to its high prevalence. A better understanding of the mechanisms of post-injury/surgery and OA/PTOA pains and identifying biomarkers that are associated with or predict MSK pain, the gap the proposed study aims to fill, will provide useful guidance on developing novel therapeutic targets for pain relief in OA and other MSK disorders. The proposed study presents a significant and timely expansion of the parent study. It will leverage the resources from the parent study and provide a unique opportunity to investigate relationship between joint structural damages, CNS alternations, and pain in a novel early OA model (PTOA, after orthopaedic injury and surgery). The study outcomes will provide valuable insights to MSK pain mechanisms, help identify new treatment targets for pain relief in this huge patient population, and eventually help with providing scientific solutions to battle against the ever- increasing opioid epidemic in the US.

项目概要/摘要 此紧急竞争性修订是对 NIAMS 特别利益通知 (NOSI) NOT-AR-23-015 的回应。 母研究 (NIAMS R01 AR077452) 旨在开发新型 MRI 技术（加速定量 MR T1ρ 和 T2 映射）来评估前路术后患者的软骨成分变化和早期退化 十字韧带重建（ACLR），是患创伤后骨关节炎的高危人群 （PTOA），我们的目的是探索肌肉骨骼（MSK）疼痛的机制并确定新的机制。 ACL 损伤和手术后以及早期 PTOA 疼痛的成像（膝盖和大脑）标记。 研究将显着扩大母研究的范围，不再只关注结构变化（“疾病”） 通过一种新颖的多模式方法来评估 OA 患者的症状（“疾病”，特别是疼痛）。 包括先进的膝盖和大脑 MRI，我们的小组将首次研究中枢神经系统 (CNS) 骨科损伤/手术后以及早期 PTOA 中疼痛的变化该研究结果将提供关键的信息。 初步数据来制定 MSK 疼痛的具体假设，并将开发新颖的成像技术 可用于未来骨科损伤/手术后疼痛机制的大规模研究以及 OA/PTOA，一个研究不足且临床需求紧迫的领域，因此，拟议的研究符合这一点。 NOSI 目标 A：为未来的创新研究或新的科学方向提供支持证据 在新型疼痛成像技术感兴趣的领域进行肌肉骨骼疾病的疼痛研究。 OA 影响着美国 30 多万人和全球 3 亿多人，它带来了巨大的健康和影响。 疼痛是显着损害的主要因素 生活质量，导致残疾，并促使患者进行临床就诊并最终进行全关节置换术 用于治疗严重 OA/PTOA 疼痛和骨科损伤后疼痛的阿片类药物处方很常见。 由于其高流行率，对国家阿片类药物危机做出了重大贡献。 了解受伤/手术后和 OA/PTOA 疼痛的机制并识别生物标志物 与 MSK 疼痛相关或预测 MSK 疼痛是拟议研究旨在填补的空白，将为以下方面提供有用的指导： 拟议的研究提出了缓解 OA 和其他 MSK 疾病疼痛的新治疗靶点。 家长研究的重大和及时的扩展将利用家长研究的资源和 提供了一个独特的机会来研究关节结构损伤、中枢神经系统改变和 研究结果将提供一种新型早期 OA 模型（PTOA，骨科损伤和手术后）的疼痛。 对 MSK 斯隆疼痛机制的宝贵见解，有助于确定缓解疼痛的新治疗目标 庞大的患者群体，并最终帮助提供科学的解决方案来对抗日益严重的疾病 美国阿片类药物流行日益严重。

项目成果

Efficient phase-cycling strategy for high-resolution 3D gradient-echo quantitative parameter mapping.

用于高分辨率 3D 梯度回波定量参数映射的高效相位循环策略。

• 发表时间: 2022-07
• 影响因子: 2.9
• 作者: Peng, Qi;Wu, Can;Kim, Jeehun;Li, Xiaojuan
• 通讯作者: Li, Xiaojuan

The QIBA Profile for MRI-based Compositional Imaging of Knee Cartilage.

基于 MRI 的膝关节软骨成分成像的 QIBA 概要。

• 发表时间: 2021
• 影响因子: 19.7
• 作者: Chalian, Majid;Li, Xiaojuan;Guermazi, Ali;Obuchowski, Nancy A;Carrino, John A;Oei, Edwin H;Link, Thomas M;RSNA QIBA MSK Biomarker Committee;SNA QIBA MSK Biomarker Committee Members
• 通讯作者: SNA QIBA MSK Biomarker Committee Members