MR Console Upgrade

MR控制台升级

• 批准号: 8446791
• 负责人: KEVIN E CONLEY
• 金额: $ 57.5万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-15 至 2015-06-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8446791
• 关键词: Affect; Aging; Animals; Brain; Brain imaging; Collaborations; Computer software; Degenerative Disorder; Diagnostic Procedure; Electronics; Foundations; Funding; Goals; Grant; Human; Image; Institution; Laboratories; Limb structure; Metabolic; Metabolism; Methods; Muscle; Noise; Physiology; Research; Research Personnel; Resolution; Scientific Advances and Accomplishments; Signal Transduction; Site; Skeletal Muscle; Surface; System; Time Study; Tissues; United States National Institutes of Health; Universities; Vendor; Washington; digital; human disease; improved; in vivo; insight; meetings; programs; repaired; skills; tool

DESCRIPTION (provided by applicant): We are one of few research groups in the world with a high field system (4.7 T) dedicated to human and animal metabolic research. Our track record of scientific advances make us a preeminent group studying muscle energetics, physiology, and metabolism with the goal of developing diagnostic methods for human diseases. Our Translational Center for Metabolic Imaging (TCMI) was established in 2009 by an ARRA "Grand Opportunity" grant to develop and disseminate these cutting-edge MR spectroscopic tools to University research sites across the US. We now serve 5 NIH funded projects (and 2 foundation grants) at the University of Washington and 4 NIH funded projects at collaborating sites. In 2010, we established a collaboration with the Integrated Brain Imaging Center (IBIC) at the University of Washington to apply our technical skills and new insights developed from skeletal muscle to understanding degenerative disease and aging in the brain. A major limitation to our program is our obsolete MR system control console, which needs frequent repair, lacks vendor support, and is hindering progress on NIH funded grants. It also cannot meet the challenge of new advances in our research. We propose to replace this 90's vintage console with new computer, software and digital electronics as well as rf electronics. This replacement would make possible a wide range of new experimental approaches for NIH funded grants in our laboratory and for collaborating investigators. The new console will permit rapid shimming, improved signal to noise, high-resolution MR methods for in vivo applications, and state-of-the-art imaging. The MAPSHIM software in the new console will allow us to rapidly and reproducibly shim human limbs that are typically off center. We expect to reduce our study time by a third. The new console allows coordinated control of the shims and gradients that will permit implementation of state- of-the-art imaging programs. This new imaging software and receiver hardware will permit rapid scout imagine for checks on surface coil placement and state-of-the-art parallel acquisition imaging programs (e.g. GRAPPA) for high-resolution images on small tissue volumes. The new digital and rf electronics will permit greatly increase signal to noise. This upgrade will directly affect 9 NIH funded grants as well as 2 foundation grants serving a total of 10 Institutions.

描述（由申请人提供）：我们是世界上少数几个研究小组的研究小组之一，该研究小组具有较高的野外系统（4.7 T），专用于人类和动物代谢研究。我们的科学进步记录使我们成为研究肌肉能量，生理和代谢的杰出群体，目的是开发人类疾病的诊断方法。我们的代谢成像转化中心（TCMI）于2009年由ARRA“宏伟的机会”赠款建立，以开发和传播这些尖端的Spectroscic先生工具到美国的大学研究网站。现在，我们在华盛顿大学提供5个NIH资助的项目（和2项基金会赠款），并在合作网站上提供4个NIH资助的项目。 2010年，我们与华盛顿大学的综合脑成像中心（IBIC）建立了合作，以运用我们的技术技能和从骨骼肌开发的新见解，以了解大脑中的退化性疾病和衰老。我们计划的主要局限性是我们过时的MR系统控制控制台，需要频繁维修，缺乏供应商支持，并阻碍了NIH资助的赠款的进展。它也无法满足我们研究中新进步的挑战。我们建议用新的计算机，软件和数字电子设备以及RF电子替换这90年代的老式控制台。这种替代者将为我们的实验室和合作调查人员提供广泛的新实验方法。新的控制台将允许快速改善，改善噪声，高分辨率的MR方法，用于体内应用和最新成像。新控制台中的Mapshim软件将使我们能够快速且可重复的湿润的人类四肢，通常是偏离中心的。我们希望将学习时间减少三分之一。新的控制台允许对垫片和梯度进行协调控制，以允许实施状态成像程序。这个新的成像软件和接收器硬件将允许快速侦察件想象一下，以检查表面线圈放置和最先进的并行采集成像程序（例如Grappa），以了解小型组织体积上的高分辨率图像。新的数字和RF电子设备将允许大大增加噪声的信号。这项升级将直接影响9个NIH资助的赠款，以及2个基金会赠款，共有10个机构。