Building research capacity in aging HIV-infected persons

建设老年艾滋病毒感染者的研究能力

• 批准号: 8524957
• 负责人: RONALD J. ELLIS
• 金额: $ 8.41万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8524957
• 关键词: AIDS/HIV problem; Address; Affect; Age; Age-Years; Aged, 80 and over; Aging; Anti-Retroviral Agents; Brain; California; Caring; Case Report Form; Centers for Disease Control and Prevention (U.S.); Certification; Cities; Clinical Research; Communities; Community Services; County; Databases; Disease; Elderly; Eligibility Determination; Evaluation; Feasibility Studies; Feedback; Focus Groups; Funding; Future; Goals; HIV; HIV Infections; Health; Human Resources; Impairment; Individual; Information Dissemination; Institutional Review Boards; Interdisciplinary Study; Intervention; Intervention Studies; Interview; Letters; Life; Logistics; Los Angeles; Medical; Methods; National Institute of Mental Health; Nervous System Physiology; Neurocognitive; Neurologic; Outcome Measure; Persons; Population; Probability; Productivity; Provider; Public Health; Publishing; Quality of life; Recruitment Activity; Reporting; Research; Research Infrastructure; Research Personnel; Resources; Risk; Secure; Site; Structure; Teleconferences; Training; Travel; Universities; Woman; antiretroviral therapy; base; cohort; community consultation; comorbidity; disability; human subject protection; interest; meetings; men; multidisciplinary; neurobehavioral; neuropsychological; peer; premature; public health relevance; quality assurance; response; sensory neuropathy; success; volunteer

DESCRIPTION (provided by applicant): A critical barrier to progress in multidisciplinary clinical research on HIV and aging is the paucity in clinical studies to date of truly older HIV-infected (HIV+) individuals - those in whom the synergistic effects of HIV and age on brain structure and function are most likely to be observed. Although HIV+ people in the U.S. are now living into old age with long-term combination antiretroviral treatment (CART) and the U.S. CDC estimates that by 2015 more than 10% of all HIV+ individuals will exceed 65 years of age (i.e., older HIV+), very few such individuals have actually been included in published reports. We propose to capitalize on a unique geographic concentration of HIV+ individuals over age 65 in a cluster of desert communities nearby to San Diego, where their proportion has already exceeded 10%. We will establish a productive, collaborative partnership between the aging HIV+ community in Riverside County and the multidisciplinary UCSD HIV Neurobehavioral Research Center (HNRC) to investigate neurological functioning among older HIV+ individuals. We will strengthen and evolve an emerging alliance between desert community activists and HNRC researchers. We will leverage the well- established, NIMH-funded HNRC infrastructure to establish this new cohort with modest support. We will demonstrate feasibility by training local personnel in high-quality clinical research evaluations and by establishing an initial cohort of 20 well-characterized older HIV+ persons. These preliminary efforts will support the establishment of an expanded clinical research infrastructure for planned future studies on interventions to maximize neurological health, productivity and quality of life in the "oldest old" HIV+ persons.

描述（由申请人提供）：艾滋病毒和衰老的多学科临床研究取得进展的一个关键障碍是，迄今为止，对真正老年艾滋病毒感染者（HIV+）的临床研究很少，即艾滋病毒和年龄的协同效应对这些人的影响。大脑的结构和功能最有可能被观察到。尽管美国的 HIV+ 患者现在通过长期联合抗逆转录病毒治疗 (CART) 进入老年，而且美国疾病预防控制中心 (CDC) 估计，到 2015 年，所有 HIV+ 患者中超过 10% 的年龄将超过 65 岁（即老年 HIV+） ，实际上很少有这样的人被纳入已发表的报告中。我们建议利用圣地亚哥附近沙漠社区群中 65 岁以上艾滋病病毒感染者的独特地理集中优势，他们的比例已超过 10%。我们将在河滨县的老年 HIV+ 社区和多学科 UCSD HIV 神经行为研究中心 (HNRC) 之间建立富有成效的合作伙伴关系，以研究老年 HIV+ 个体的神经功能。我们将加强和发展沙漠社区活动家和 HNRC 研究人员之间的新兴联盟。我们将利用 NIMH 资助的完善的 HNRC 基础设施，在适度的支持下建立这个新群体。我们将通过培训当地人员进行高质量的临床研究评估并建立一个由 20 人组成的初始队列来证明可行性 具有明确特征的老年艾滋病病毒感染者。这些初步工作将支持建立扩大的临床研究基础设施，以用于计划的未来研究干预措施，以最大限度地提高“高龄”艾滋病病毒感染者的神经健康、生产力和生活质量。