Reducing blood pressure in mid-life adult binge drinkers: the role of microvascular function and sympathetic activity

降低中年成人酗酒者的血压：微血管功能和交感神经活动的作用

基本信息

批准号：
10834571
负责人：
Chueh-Lung Hwang
金额：
$ 4.36万
依托单位：
UNIVERSITY OF TEXAS ARLINGTON
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-10 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10834571
关键词：
Acceleration Address Adult Alcohol consumption Alcohols Aorta Area Arteries Blood Blood Pressure Blood Vessels Blood Volume Blood flow Brain Brain Injuries Brothers Buffers Cardiovascular system Career Mobility Carotid Arteries Chronic Communication Dementia Development Disease Doppler Ultrasound Dryness Elasticity Enrollment Event Female Fostering Future Goals Grant Health Heart Hypertension Impaired cognition Kinesiology Knowledge Knowledge acquisition Laboratories Leadership Left ventricular structure Limb structure Mentors Mentorship Minority Groups Mission Myocardial Contraction National Institute on Alcohol Abuse and Alcoholism Nerve Organ Parents Patient Self-Report Pattern Phase Physiologic pulse Physiology Play Postdoctoral Fellow Property Questionnaires Research Research Personnel Research Priority Research Project Grants Research Support Research Training Risk Risk Factors Role Scientist Spottings Training Travel Underrepresented Minority Vascular System alcohol research arterial stiffness binge drinker binge drinking blood pressure reduction blood pressure regulation career career development career preparation doctoral student heart function hemodynamics member middle age novel organ injury parent project phosphatidylethanol prevent programs senior faculty skills theories tonometry wasting

项目摘要

Project Summary/Abstract This supplement supports the diversity candidate, a second-year doctoral student in Kinesiology, and fosters his research career development toward becoming a scientist in the field of vascular physiology and alcohol- related health research. The research training and professional development activities, under this supplement, are facilitated by a strategic mentoring plan and incorporated into the parent R00 project. The parent R00 grant has been targeting microvascular function and sympathetic nerve activity to understand the mechanisms underlying alcohol-attributable contribution to elevated systolic blood pressure and prevent the negative health consequences in mid-life adults. Nevertheless, binge drinking, the most common pattern of excessive alcohol use, can also cause elevated systolic blood pressure through increased arterial stiffness which, in theory, results in hemodynamic changes, such as enhance aortic wave reflection and carotid artery wave intensity. These hemodynamic changes play a significant role not only in blood pressure regulation but also in the function of the heart and the brain. Understanding alcohol-induced arterial stiffening and the related hemodynamic changes is significant because it helps predict the subsequent progression of organ injury by alcohol. The diversity candidate will complete the proposed research to address the overarching hypothesis – “chronic binge drinking contributes to the changes in aortic and carotid hemodynamic in mid-life adults due to arterial stiffness.” During the supplement period, the diversity candidate will receive mentored training with the PI of the parent project to enhance his knowledge and skills in alcohol use assessments and the harmful effect of binge drinking on arterial stiffness and hemodynamics. He will also receive mentored professional development to enhance his communication, leadership, and management skills, as well as professionalism. The PI is a female early-stage investigator and is committed to career and professional development for her trainees. The proposed training plan under this supplement will be facilitated by a senior faculty member, Dr. R. Matthew Brothers. This supplement will not only help facilitate the candidate’s progress toward his next stage of career, but also help enrich the PI’s reach program with the involvement of trainees from diverse backgrounds and establish her laboratory at the early stage of her career. In addition, increasing the number of scientists from non-traditional backgrounds (i.e., kinesiology) in the field of alcohol research will enhance the diversity of alcohol research, ultimately accelerating the pace of research in alcohol-related health. Therefore, this diversity supplement is consistent with the overarching mission and research priority areas of NIAAA.

项目概要/摘要该补充材料支持多样性候选人，运动机能学二年级博士生，并培养他的研究生涯发展为成为血管生理学和酒精领域的科学家- 相关的健康研究。研究培训和专业发展活动，根据本补充，由战略指导计划推动并纳入母公司 R00 项目母公司 R00 赠款。一直针对微血管功能和交感神经活动来了解其机制酒精导致收缩压升高的潜在因素并预防对健康的负面影响然而，酗酒是过量饮酒的最常见模式。使用，还可能通过增加动脉僵硬度而导致收缩压升高，理论上，导致血流动力学改变，如增强主动脉波反射和颈动脉波强度。这些血流动力学变化不仅在血压调节中发挥着重要作用，而且在了解酒精引起的动脉硬化及相关的心脏和大脑功能。血流动力学变化非常重要，因为它有助于预测器官损伤的后续进展多样性候选人将完成拟议的研究，以解决总体假设 - “长期酗酒会导致中年成年人主动脉和颈动脉血流动力学的变化，原因是在补充期间，多元化候选人将接受以下指导培训：父项目的 PI，以提高他在酒精使用评估及其有害影响方面的知识和技能他还将接受专业人士的指导。发展以提高他的沟通、领导和管理技能以及专业精神。 PI 是一名女性早期研究员，致力于她的职业和专业发展本补充材料中拟议的培训计划将由高级教员 Dr. 负责协助。 R. Matthew Brothers。该补充材料不仅有助于促进候选人下一步的进步。职业阶段，而且还通过来自不同领域的学员的参与来帮助丰富 PI 的影响力计划此外，她还在职业生涯的早期阶段就建立了自己的实验室。来自非传统背景（即运动机能学）的科学家在酒精研究领域将增强酒精研究的多样性，最终加快了酒精相关健康研究的步伐。这种多样性补充与 NIAAA 的总体使命和研究优先领域是一致的。