Michigan Collaborative Hub for TMD Patient-Centric Research (MICH T PCR)

密歇根州 TMD 以患者为中心的研究合作中心 (MICH T PCR)

• 批准号: 10834394
• 负责人: ALEXANDRE DASILVA
• 金额: $ 31.2万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-06 至 2024-09-05
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10834394
• 关键词: Affect; Animal Model; Basic Science; Biological Markers; Biological Sciences; Caring; Center for Translational Science Activities; Cessation of life; Clinic; Clinical; Clinical Research; Clinical Trials; Collaborations; Community Practice; Data Science; Dedications; Dental; Development; Diagnostic; Disease; Divorce; Ecosystem; Education; Engineering; Environment; Etiology; Evidence based treatment; Female; Foundations; Future; Goals; Grant; Health Technology; Heterogeneity; Impairment; Infrastructure; Injury; Investments; Joints; Leadership; Medical; Michigan; Modeling; National Institute of Dental and Craniofacial Research; Nervous System; Neurosciences; Pain; Patients; Phase I/II Trial; Population; Positioning Attribute; Procedures; Process; Public Health; Quality of life; Regenerative Medicine; Research; Research Personnel; Research Training; Resources; Schools; Sex Bias; Standardization; Structure; Symptoms; TMD treatment; Technology; Temporomandibular Joint Disorders; Testing; Tissue Engineering; Translating; Translations; Universities; Vision; clinical application; clinical care; clinical practice; clinical translation; clinically relevant; design; evidence base; experience; functional outcomes; health data; human disease; implementation strategy; improved; innovation; innovative technologies; multidisciplinary; muscular system; organizational structure; patient oriented; pre-clinical; programs; protocol development; sound; success; technology validation; translational pipeline

ABSTRACT Temporomandibular disorders (TMD) are a significant public health and societal problem that manifests itself in pain, compromised joint and overall function, and affecting up to 10% of the population. Since pain frequently occurs with a plethora of mostly subjective symptoms, TMD are frequently misdiagnosed and treatments are frequently non-standardized and ineffective. While investments in TMD research have been made over the past several decades, there has been limited success in translating such research to the clinic. Likewise, the heterogeneity in symptoms and complexity of a disease that impacts the joint, muscle, and nervous systems, complicates the understanding of disease etiology and mechanisms, and impairs the development of evidence- based therapies. As a result, basic and clinical research on TMD are frequently divorced from one another, with insufficient linkages between basic discoveries and clinical needs. To advance basic, clinical, and translational TMD research in an integrated manner, we will establish an interactive, multi- disciplinary team at Michigan in partnership with the clinical practice community as a means of forming a patient-centered collaborative ecosystem. The goal of our IMPACT program is to transform the treatment of TMD patients through the translation of clinically-relevant innovations. Our vision is to integrate life science, engineering and health technologies to solve clinically-defined problems in a translational infrastructure environment. Herein, we will develop an organizational structure, ecosystem and operational procedures for establishing a consortium that integrates basic and clinical research in TMD and guides the most promising research toward translation in an evidence-based manner to improve clinical care. To achieve this vision, we leverage the experience and leadership of the NIDCR center program in regenerative medicine (DOCTRC) at Michigan to guide our planning of how to best catalyze basic research through the translational pipeline and into the clinic. In this R34, we will design the structure and develop an implementation strategy for the future TMD collaborative via the following aims: 1) Develop a multi-disciplinary organizational structure and processes to inform basic and patient-centered research that yield a mechanistic understanding of TMDs and development of diagnostics and therapies suitable for translation to clinical practice. 2) Integrate diverse teams that support the collaboration of basic and clinical research and processes for selecting research themes and projects that can be translated into clinical practice. 3) Formulate operating procedures to support the clinical translation of innovative TMD technologies and therapies. Upon completion of the aims, we will be uniquely positioned to advance basic and clinical TMD research, research training, and translation to evidence-based treatments leading to a transformation in TMD care.

抽象的 颞下颌关节紊乱病 (TMD) 是一个重大的公共卫生和社会问题，表现在 疼痛、关节和整体功能受损，影响多达 10% 的人口。由于经常疼痛 TMD 的发生大多伴有大量主观症状，TMD 经常被误诊，治疗方法也不尽相同。 经常是不标准化和低效的。虽然对 TMD 研究的投资已超过 过去几十年来，将此类研究转化为临床的成功有限。同样， 影响关节、肌肉和神经系统的疾病的症状和复杂性的异质性， 使对疾病病因和机制的理解复杂化，并损害证据的发展 为基础的疗法。因此，TMD 的基础研究和临床研究经常脱节。 另一方面，基本发现与临床需求之间的联系不足。为了提升基础， 以整合的方式进行临床和转化TMD研究，我们将建立一个互动的、多元的 密歇根州的纪律团队与临床实践界合作，作为一种手段 形成以患者为中心的协作生态系统。我们 IMPACT 计划的目标是改变 通过转化临床相关创新来治疗 TMD 患者。我们的愿景是整合 生命科学、工程和健康技术，以转化的方式解决临床定义的问题 基础设施环境。在此，我们将制定组织结构、生态系统和运营 建立整合TMD基础研究和临床研究并指导TMD研究的联盟的程序 最有前途的研究是以循证方式翻译以改善临床护理。达到 为了实现这一愿景，我们利用 NIDCR 中心再生医学项目的经验和领导力 （DOCTRC）在密歇根州指导我们如何通过转化最好地促进基础研究的规划 管道并进入诊所。在本 R34 中，我们将设计结构并制定实施策略 未来TMD合作将通过以下目标： 1）发展多学科的组织结构 为基础研究和以患者为中心的研究提供信息和流程，从而对 TMD 产生机械性的理解 以及开发适合转化为临床实践的诊断和疗法。 2）整合多元化 支持基础和临床研究合作以及研究选择流程的团队 可以转化为临床实践的主题和项目。 3）制定操作规程 支持创新 TMD 技术和疗法的临床转化。完成目标后，我们 将具有独特的优势，推动基础和临床 TMD 研究、研究培训和转化 基于证据的治疗导致 TMD 护理的转变。