Core D: Animal Experimentation & Wound Healing

核心 D：动物实验

基本信息

批准号：
8203935
负责人：
THOMAS S MCCORMICK
金额：
$ 17.47万
依托单位：
CASE WESTERN RESERVE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8203935
关键词：
Address Animal Experimentation Animal Model Animals Area Biochemistry Biology Chemicals Chronic Clinic Collaborations Commit Communities Consultations Cost Savings Cutaneous Disease Educational process of instructing Ensure Environment Experimental Animal Model Faculty Foundations Funding Gene Expression Profiling Healed Human Image Immune response In Vitro Joints Knockout Mice Measurement Medical center Methods Modeling Molecular Mus National Institute of Arthritis and Musculoskeletal and Skin Diseases Ohio Operative Surgical Procedures Phase Phenotype Photobiology Preclinical Testing Preparation Procedures Protocols documentation Reading Recruitment Activity Research Research Personnel Resources Retrieval Services Skin Skin Neoplasms Societies System Therapeutic Thick Tissue Extracts Tissue Sample Tissues Training Transgenic Animals Transgenic Mice Transgenic Organisms Translational Research Transplantation Tumor Biology Ultraviolet B Radiation United States Department of Veterans Affairs Work Wound Healing animal facility animal tissue base carcinogenesis clinical practice design healing implantation in vivo interest keratinocyte knockout animal loss of function medical schools melanoma member mouse model novel therapeutics practice-based research network professor programs research study response skin disorder translational approach tumor wound

项目摘要

The SDRC Animal Experimentation Core has traditionally emphasized several thematic areas including photobiology, carcinogenesis, transgenic animal models, xenogenic transplantation and immunodermatology. Based upon member demands, the Animal Experimentation Core has begun to phase-in a new area of interest, wound healing. The expansion of this research focus is reflected in renaming the core the "Animal Experimentation & Wound Healing Core" (AEWHC). The Core has also appointed an Associate Director, Dr. Kurt Lu, who joined the Faculty in 2008, and is an up and coming wound healing researcher. Demand for animal facilities and different animal models have continued to increase as new investigators have been recruited to our program, several of whom are employing wound healing studies as a means to investigate immune response in a cutaneous wound environment or cellular differentiation and activation in response to wounding. One common interest is in non-healing, chronic wounds. The AEWHC is poised to assist these investigators by establishing connections with expert collaborators such as Dr. Chandan Sen, Executive Director of the OSU Comprehensive Wound Center (CWC). Dr. Sen, a professor of Surgery and of Molecular and Cellular Biochemistry, is on the board of directors of the National Wound Healing Society. He is a leading expert in gene expression profiling of healing and non-healing wounds. Dr. Sen acts as a consultant to our Core on chronic wounds. Further, Dr. Sen and the OSU CTSA have committed to funding a joint project on wound healing in collaboration with the SDRC in recognition of the value that the SDRC brings to cutaneous research. The Core will continue to ensure that animal-related studies are properly designed and evaluated, and will continue to provide expertise and guidance in animal experimentation that provides support for, or leads to new, translational cutaneous projects from SDRC members.

SDRC 动物实验核心传统上强调几个主题领域，包括光生物学、致癌作用、转基因动物模型、异种移植和免疫皮肤病学。根据会员要求，动物实验核心已开始逐步进入一个新的兴趣领域：伤口愈合。这一研究重点的扩大体现在将核心重命名为“动物实验和伤口愈合核心”(AEWHC)。核心也有任命Kurt Lu博士为副主任，他于2008年加入学院，是一位崭露头角的新人伤口愈合研究员。对动物设施和不同动物模型的需求持续增长随着我们的计划招募了新的调查员，其中一些人正在雇用伤口愈合研究作为研究皮肤伤口环境或细胞免疫反应的一种手段响应伤害的分化和激活。一种共同的兴趣是不可治愈的、慢性的伤口。 AEWHC 准备通过与专家建立联系来协助这些调查人员合作者，例如 OSU 综合伤口中心执行主任 Chandan Sen 博士（化学武器公约）。 Sen 博士是外科以及分子和细胞生物化学教授，也是该公司的董事会成员国家伤口愈合协会理事。他是基因表达谱领域的领先专家愈合和未愈合的伤口。 Sen 博士担任我们慢性伤口核心的顾问。此外，博士。 Sen 和 OSU CTSA 承诺与以下机构合作资助一个伤口愈合联合项目： SDRC 认可 SDRC 为皮肤研究带来的价值。核心将继续确保与动物相关的研究得到适当的设计和评估，并将继续提供动物实验方面的专业知识和指导，为新的转化提供支持或带来新的转化 SDRC 成员的皮肤项目。