Core C: Translational Research

核心 C：转化研究

• 批准号: 8203930
• 负责人: ELMA D BARON
• 金额: $ 17.47万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8203930
• 关键词: Antioxidants; Biopsy; Blood; Bulla; Clinic; Clinical; Clinical Data; Clinical Sciences; Clinical Trials; Clinical Trials Design; Collaborations; Communities; Comprehensive Cancer Center; Conduct Clinical Trials; Core Facility; Data; Dermatologic; Dermatology; Development; Developmental Therapeutics Program; Devices; Disease; Dose; Education; Ensure; Equipment; Fostering; Foundations; Guidelines; Hospitals; Housing; Human; Image; In Vitro; Informed Consent; Institution; Institutional Review Boards; Intervention; Investigation; Laboratories; Laboratory Study; Lead; Link; Medical center; Mentors; Monitor; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Nurses; Outcomes Research; Patients; Photochemotherapy; Physicians; Preparation; Procedures; Protocols documentation; Punch Biopsy; Records; Recruitment Activity; Research; Research Personnel; Resources; Safety; Schedule; Science; Services; Simulate; Skin; Solar Energy; Specimen; Structure; Suction; Sunscreening Agents; System; Technology; Testing; Tissues; Topical agent; Translational Research; UV Radiation Exposure; Ultrasonography; United States Department of Veterans Affairs; Universities; University Hospitals; Water; bench to bedside; cohort; cost; cost effective; design; human study; human subject; human tissue; in vivo; interest; meetings; member; new technology; novel; research study; skin disorder; translational approach; volunteer

Translational Research Core Facility is specifically designed to promote and facilitate involvement of human subjects for skin and skin disease-related research. It aims to derive maximum information from human studies by providing a resource that integrates organization of patient cohorts with mechanistic studies using tissues, outcomes research, clinical trials, and laboratory investigation. This Core is structured to meet the SDRC membership's needs for human tissue, (e.g. punch biopsies, keratomes, suction blisters), to provide the SDRC membership with enabling technologies for human skin investigation (e.g. simulated solar radiation, chromometer, transepidermal water loss device), and to lead in the development of novel technologies that will benefit SDRC membership (e.g. imaging system for photodynamic therapy, skin ultrasound, in vivo confocal imaging). It aims to provide a cost-efficient, central resource to identify and recruit volunteers to participate in human in vivo studies and/or donate blood or skin biopsy tissue for ex vivo/in vitro investigations. The utilization of core functions is expanded mainly by active interactions with physicians who refer patients and with other investigators through the Clinical and Translational Science Collaborative, Case Comprehensive Cancer Center, Center for Aids Research, and other research foci within the University. A research assistant coordinates these services. The core also aims to provide overall management of clinical trials of novel therapies brought from the laboratory to the bedside with emphasis on providing optimal translational and clinical data. A group with expertise in general trial design, regulatory and compliance aspects of human studies, assemble to efficiently direct or conduct high quality studies that arise through interaction with various investigators interested in skin research. Additionally, interactions between clinical and laboratory researchers are fostered to insert adjunctive laboratory studies to clarify mechanisms of action of therapies and pathomechanisms of disease. The core also provides support, mentoring and education regarding human research compliance, to members of the SDRC.

转化研究核心设施是专门为促进和促进人类的参与而设计的 皮肤和皮肤病相关研究的课题。它的目的是从人类那里获取最大的信息 通过提供将患者队列的组织与机械研究相结合的资源来进行研究 组织、结果研究、临床试验和实验室研究。该核心的结构是为了满足 SDRC 会员对人体组织的需求（例如穿刺活检、角膜刀、吸泡），以提供 SDRC 成员拥有人体皮肤研究的支持技术（例如模拟太阳光） 辐射、比色计、经皮失水装置），并引领新型产品的开发 将有利于 SDRC 会员的技术（例如用于光动力治疗的成像系统、皮肤 超声、体内共焦成像）。它的目的是提供一个具有成本效益的中央资源来识别和 招募志愿者参与人体体内研究和/或为前任捐献血液或皮肤活检组织 体内/体外研究。核心功能的利用主要通过与 通过临床和转化科学转介患者和其他研究人员的医生 协作、案例综合癌症中心、艾滋病研究中心和其他研究重点 大学内。研究助理负责协调这些服务。该核心还旨在提供整体 管理从实验室到临床的新疗法的临床试验，重点是 提供最佳的转化和临床数据。一个在一般试验设计、监管和 人类研究的合规性方面，聚集起来有效指导或进行高质量的研究 通过与对皮肤研究感兴趣的各种研究人员的互动。此外，之间的相互作用 培养临床和实验室研究人员插入辅助实验室研究以阐明机制 治疗作用和疾病的病理机制。核心还提供支持、指导和 向 SDRC 成员提供有关人类研究合规性的教育。