Biomolecular Analysis Core

生物分子分析核心

基本信息

批准号：
8132692
负责人：
JOHN W TURK
金额：
$ 8.93万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-04-01 至 2016-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8132692
关键词：
Amino Acids Area Biocompatible Materials Biological CXCL14 gene Carbohydrates Charge Complex Data Detection Development Diabetes Mellitus Disease Electronics Equipment Equipment and supply inventories Event Extramural Activities Fatty Acids Fees Floor Goals Group Meetings Instruction Isotope Labeling Isotopes Laboratories Lipids Mass Spectrum Analysis Methods Obesity Pathogenesis Peptides Physiological Post-Translational Protein Processing Preparation Procedures Proteins Publications Research Research Personnel Resources Sampling Scientist Sensitivity and Specificity Services Site Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Sphingolipids Sterols Students System Techniques Training Universities Visit Washington analytical method cost innovation instrument interest investigator training ionization lipid structure member nutrition operation oxidation polyol post-doctoral training programs skills web site

项目摘要

The goal of the BMAC is to offer a comprehensive range of MS analyses for the structural characterization and quantification of nutrition-related biomolecules for NORC investigators. The predominant BMAC objective is to provide means for NORC investigators to gain maximum benefit from the power of MS with a focus on three areas of need: 1) To apply the sensitivity and specificity of MS to detect and quantify low abundance biomolecules; 2) To develop innovative MS techniques for detection and structural characterization of nutritionor obesity-related biomolecules; and 3) To provide MS training for students and fellows in nutrition or obesity research. Because MS analyses are labor-intensive and require specialized skills, it is often more economical and practical for BMAC Core staff to perform MS analyses. In cases where sustained demand for analyses or development of analytical techniques is anticipated, members of investigators' laboratories are trained to perform appropriate MS procedures.

BMAC的目的是为NORC研究者提供与营养相关的生物分子的结构表征和量化的全面分析。主要的BMAC目标是为NORC调查人员提供手段，以从MS的权力中获得最大收益，重点是需要三个领域：1）应用MS的灵敏度和特异性来检测和量化低丰度生物分子； 2）开发创新的MS技术，以检测和结构表征与肥胖相关的生物分子的检测和结构表征； 3）为营养或肥胖研究中的学生和研究员提供MS培训。由于MS分析是劳动密集型的，需要专业技能，因此BMAC核心人员进行MS分析通常更经济和实用。如果预计对分析技术的持续需求或开发分析技术的发展，则培训研究人员实验室成员以执行适当的MS程序。