Bioinformatics Core Facility

生物信息学核心设施

• 批准号: 8340336
• 负责人: CHARLES M. PEROU
• 金额: $ 28.63万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-23 至 2015-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8340336
• 关键词: Area; Bioinformatics; Biological Assay; Biological Models; Cancer Center; Cancer Survivorship; Clinical; Clinical Data; Core Facility; Data; Data Analyses; Data Set; Data Storage and Retrieval; Databases; Development; Elements; Faculty; Fostering; Gene Expression; Gene Expression Microarray Analysis; Genomics; Genotype; Goals; Grant; Human Resources; Link; Maintenance; Mission; Patients; Research; Research Infrastructure; Research Personnel; Resources; Sampling; Specimen; System; Technology; Tissue Procurements; Translational Research; anticancer research; base; cohort; cost; data integration; data management; experience; member; patient registry; programs; tool; tool development; tumor

Bioinformatics is critical for any cancer center, allowing researchers to tap the ever-growing data sets afforded by new cancer research technologies. However daunting, massive data sets are being created, must be analyzed, and need to be related to translafional and clinical end points. LCCC expertise in this area began with the genomics program, particularly gene expression microarray analysis. By necessity, the personnel, computafional infrastructure, and broad faculty expertise was built through internal and external recruitment. In the last three years, capabilifies rapidly expanded to capture clinical data and annotate specimens. The Lineberger Data Warehouse (LDW) was created to allow Interactive use of mulfiple oracle based data repositories. With this expanded staff and mission, the genomics and bioinformatics were divided into two resources. The relafionships between the Bioinformatics, Biostatisfics and Data Management, Genomics and the new Next Generafion and Genotyping Core will be seamless. The Bioinformafic Core's goals are to confinue to provide bioinformafics tools, databases for the storage and analysis of genomic data, for the storage and analysis of clinical/pafient data, and to provide tools to link these disfinct data types together to foster translational research discoveries. Incorporafion of new enfifies, such as the Cancer Survivorship Cohort, is occurring. The key element remains the Bioinformafics Core Central Patient Registry which provides and tracks all pafients after assigning a unique research identifier. The group has significant experience with genomic database development and curation, genomic data analysis and tool development, clinical database development, and linking these together through the LDW. The core will expand capabilifies to include new genomic plafi'orms and new clinical databases/tumor types. The core requests $270,568, representing 13% of its total operating costs to accomplish its ambitious goals. All core use in 2009 was by members. The co-directors, Drs. Perou and Hayes, are leaders in genomic analysis and its integration with clinical endpoints.

生物信息学对于任何癌症中心都至关重要，使研究人员可以利用不断增长的数据集 由新的癌症研究技术提供。但是，正在创建艰巨的数据集， 必须进行分析，并且需要与翻译和临床终点有关。 LCCC的专业知识 区域始于基因组学计划，特别是基因表达微阵列分析。必要， 人员，计算基础设施和广泛的教师专业知识是通过内部和外部建立的 招聘。在过去的三年中，Capabilied迅速扩展以捕获临床数据和注释 标本。创建了LineBerger数据仓库（LDW），以允许使用Mulfiple Oracle的交互式使用 基于数据存储库。随着员工和任务的扩大，基因组学和生物信息学被划分 分为两个资源。生物信息学，生物稳定和数据管理之间的重组， 基因组学和新的下一个生物和基因分型核心将是无缝的。 BioInformafic核心的目标是限制提供生物Informafics工具，存储数据库和 基因组数据的分析，用于临床/平坦数据的存储和分析以及提供链接的工具 这些数据类型共同培养转化研究发现。融合了新的融合， 例如癌症生存队列发生。关键元素仍然是生物Informafics核心 分配独特的研究标识符后，中央患者注册表提供并跟踪所有水平。 该小组在基因组数据库开发和策划，基因组数据方面具有丰富的经验 分析和工具开发，临床数据库开发，并通过LDW将它们联系在一起。 该核心将扩大胶囊，包括新的基因组PLAFI'ORM和新的临床数据库/肿瘤类型。 核心要求$ 270,568，占其雄心勃勃的目标的总运营成本的13％。 2009年的所有核心用途都是成员。联合导演，博士。 Perou和Hayes是基因组领导者 分析及其与临床终点的整合。