TASK FORCE FOR OBESITY RESEARCH AT SOUTHWESTERN

西南肥胖研究工作组

• 批准号: 8363907
• 负责人: JAY D. HORTON
• 金额: $ 1.61万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363907
• 关键词: Address; Advisory Committees; Animal Model; Behavioral; Brain; Collaborations; Development; Eating; Energy Metabolism; Event; Food Energy; Fostering; Funding; Goals; Grant; Human; Human Genetics; Lead; Liver; Medical; Medical center; Metabolic; Metabolic syndrome; Metabolism; Molecular; Molecular Biology; Mus; National Center for Research Resources; Obesity; Organ; Plasma; Play; Principal Investigator; Research; Research Infrastructure; Research Personnel; Resources; Role; Sampling; Services; Source; Translations; United States National Institutes of Health; base; cost; glucose metabolism; in vivo; lipid metabolism; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. UT Southwestern Medical Center at Dallas has assembled four teams to focus on a major medical problem in the U.S. - obesity and the metabolic syndrome. This project has created mechanisms to bring together diverse groups of investigators to investigate the behavioral, metabolic, and molecular events that cause obesity and the metabolic syndrome. The major focus of this effort will be on the brain and liver, organs that both play central roles in the development of obesity and its adverse metabolic consequences. Our goals are to better understand how the brain regulates food intake and energy expenditure and to reveal how dysregulation of glucose and lipid metabolism in the liver contributes to the development of the metabolic syndrome. To address these objectives, we have developed four research teams that vary in approaches and expertise that will interact extensively to pursue the shared goals of this project. Collaborations among investigators will occur on two levels. Within each team, extensive exchanges between investigators will foster direct collaborative efforts. Interactions will also occur between the four major teams to capitalize on the diverse expertise within each of the four groups and to provide comprehensive approaches to our major objectives. These four teams are: Team 1: Central Regulators of Energy Metabolism (Lead Investigator, Keith Parker); Team 2: Molecular Biology of Energy Metabolism (Lead Investigator, Jay D. Horton); Team 3: In Vivo Intermediary Metabolism (Lead Investigator, Craig Malloy) and Team 4: Human Genetics and Energy Metabolism (Lead Investigator, Scott Grundy). Over the next three years, the major objectives will be to: 1) develop a program to foster interdisciplinary interactions at UT Southwestern to study obesity and the metabolic syndrome; 2) develop a state-of-the-art program to elucidate the metabolic and molecular basis of obesity and the metabolic syndrome using genetically modified mice; and 3) support the translation of scientific findings made in animal models to humans. This study uses the Research Resource for the 2H and 13C NMR of plasma samples from humans. It is classified here as a service project because the actual use of the spectrometers is directed by Dr. Jeff Browning.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 达拉斯的UT西南医疗中心已经组建了四支球队，专注于美国的主要医疗问题 - 肥胖和代谢综合症。该项目创造了将各种研究人员组合在一起的机制，以研究导致肥胖症和代谢综合征的行为，代谢和分子事件。这项工作的主要重点将放在大脑和肝脏上，它们在肥胖的发展及其不良代谢后果中都起着重要作用。我们的目标是更好地了解大脑如何调节食物摄入和能量消耗，并揭示肝脏中葡萄糖和脂质代谢的失调如何有助于代谢综合征的发展。为了解决这些目标，我们开发了四个研究团队，这些研究团队在方法和专业知识上都有各种不同的互动，以实现该项目的共同目标。研究人员之间的合作将在两个层面上进行。在每个团队中，调查人员之间的广泛交流将促进直接的合作努力。这四个主要团队之间也将发生互动，以利用四组中每个小组的各种专业知识，并为我们的主要目标提供全面的方法。这四个团队是：1团队：能源代谢的中央监管者（首席研究员，基思·帕克）； 小组2：能量代谢的分子生物学（主要研究员，Jay D. Horton）；团队3：体内中介代谢（首席研究员，克雷格·马洛伊（Craig Malloy））和4团队：人类遗传学和能量代谢（首席研究员，斯科特·格伦迪（Scott Grundy））。在接下来的三年中，主要目标是：1）制定一项计划，以促进UT西南部的跨学科互动，以研究肥胖和代谢综合征； 2）制定最先进的计划，以使用转基因小鼠阐明肥胖和代谢综合征的代谢和分子基础； 3）支持将动物模型中的科学发现转化为人类。 这项研究使用了来自人类血浆样品的2H和13C NMR的研究资源。 它在这里被归类为一个服务项目，因为光谱仪的实际使用是由Jeff Browning博士指示的。