UT Southwestern NORC

UT 西南 NORC

基本信息

批准号：
10512731
负责人：
JAY D. HORTON
金额：
$ 123万
依托单位：
UT SOUTHWESTERN MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-07-01 至 2027-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10512731
关键词：
3-Dimensional Address Animal Model Animals Award Behavioral Biochemical Blood Blood Pressure Body Temperature Budgets Cardiovascular system Cell Separation Cells Cessation of life Clinical Collaborations DNA Sequencing Facility Dementia Development Diabetes Mellitus Digestive System Disorders Direct Costs Discipline Disease Doctor of Philosophy Elements Endocrinology Energy Metabolism Extramural Activities Faculty Fatty acid glycerol esters Funding Gene Expression Gene Expression Profiling Genetic Glucose Clamp Goals Heart Rate Homeostasis Hormones Human Hypertension Image Individual Infrastructure Interdisciplinary Study Intervention Lipids Liver Liver diseases Malignant Neoplasms Mass Spectrum Analysis Measurement Mentors Metabolic Metabolic Diseases Metabolic Pathway Metabolic syndrome Metabolism Molecular National Institute of Diabetes and Digestive and Kidney Diseases Obesity Obesity associated cancer Obesity associated disease Organ Paper Pathway interactions Peripheral Phenotype Prevention strategy Public Health Regulation Research Research Personnel Research Project Grants Research Support Risk Scientist Series Services Signal Pathway Skeletal Muscle Speed Telemetry Time Tissues Training Translating Translations adipocyte biology base clinically relevant disability exome sequencing imaging modality improved in vivo innovation member metabolic phenotype next generation non-alcoholic fatty liver disease novel therapeutic intervention nutrition obesity treatment post-doctoral training programs single cell sequencing single-cell RNA sequencing spectroscopic imaging transcriptome sequencing willingness

项目摘要

PROJECT SUMMARY/ABSTRACT – Overview: The overarching goal of the UTSW NORC is to enhance research efforts in nutrition and obesity by facilitating interdisciplinary interactions to speed translation of basic scientific discoveries into clinically relevant interventions in humans that improve public health. We have assembled a highly interactive and collaborative interdisciplinary team of investigators at UT Southwestern that harnesses expertise from diverse disciplines, with a goal of defining the behavioral, metabolic, genetic, and molecular mechanisms contributing to obesity and obesity-induced disease. The UTSW NORC research base consists of 158 investigators from 27 different Departments. These investigators have 230 extramurally funded nutrition/obesity-related research grants that total more than $74 million/yr in direct costs. To facilitate interdisciplinary research and the exchange of ideas, our NORC has created the following thematically related Teams: Team 1: Central Regulation of Energy Metabolism; Team 2: Adipocyte Biology and Energy Metabolism; Team 3: Obesity-induced Peripheral Organ Disease; and Team 4: Nutrition, Obesity, and Cancer. Within each team, we have integrated scientists from a wide spectrum of disciplines to comprehensively address the biochemical, metabolic, and clinical consequences of obesity and related diseases. Each Team has a mixture of senior, mid-level, and junior scientists, which will enhance the development of junior scientists and increase the likelihood of successful collaborations. The P&F program will support four new investigators/year who will also be assigned to one of the four research Teams. To support our research efforts, we have established four cores and a Clinical Element to provide state-of- the art services that exceed the capabilities, availability and/or budgets of individual NORC investigators. The Animal Phenotyping/Metabolism Core provides an extensive array of blood metabolites and hormones, 50+ metabolic cages, telemetry measurements of blood pressure, heart rate, core body temperature, and activity, multiple imaging modalities to characterize fat distribution, and hyperinsulinemic-euglycemic clamps and primary cell isolation. The Lipid Mass Spectrometry Core provides comprehensive quantification of lipids in cells, tissues, and blood. The Quantitative Metabolism and Imaging Core provides sophisticated flux measurements of metabolic pathways in vivo and 1H imaging and spectroscopy to characterize skeletal muscle and liver lipid content in humans. The Genetics, Single Cell Sequencing & RNA seq core provides exome sequencing and gene expression and analysis. All cores provide services for animal and human research, supporting the ability to translate findings more rapidly from animal models into testable hypothesis in humans. The UTSW NORC provides an important mechanism for a large group of diverse investigators to coalesce and focus their research efforts related to nutrition and obesity to accelerate translation of basic scientific discoveries into clinically relevant interventions in humans to improve public health.

项目摘要/摘要 – 概述： UTSW NORC 的总体目标是通过以下方式加强营养和肥胖方面的研究工作：促进跨学科互动，加速将基础科学发现转化为临床相关成果我们组建了一个高度互动和协作的团队。德州大学西南分校的跨学科研究团队利用不同学科的专业知识，目标是确定导致肥胖的行为、代谢、遗传和分子机制和肥胖引起的疾病。 UTSW NORC 研究基地由来自 27 个不同部门的 158 名研究人员组成。研究人员拥有 230 项外部资助的营养/肥胖相关研究补助金，总额超过 74 美元百万/年的直接成本为了促进跨学科研究和思想交流，我们的 NORC 建立了创建了以下主题相关的团队：团队 1：能量代谢的中央调控团队 2：脂肪细胞生物学和能量代谢；第 3 组：肥胖引起的周围器官疾病；第 4 组：在每个团队中，我们都整合了来自各个领域的科学家。全面解决肥胖和肥胖的生化、代谢和临床后果的学科每个团队都有高级、中级和初级科学家的混合，这将增强对相关疾病的研究。 P&F 项目将促进初级科学家的发展并增加成功合作的可能性。每年支持四名新研究人员，他们也将被分配到四个研究团队之一。为了支持我们的研究工作，我们建立了四个核心和一个临床要素，以提供最先进的超出 NORC 调查员个人能力、可用性和/或预算的艺术服务。动物表型/代谢核心提供广泛的血液代谢物和激素，50 多种代谢笼、血压、心率、核心体温和活动的遥测测量，多种成像方式来表征脂肪分布，以及高胰岛素-正常血糖钳和原代细胞分离。脂质质谱核心提供脂质的全面定量。定量代谢和成像核心提供复杂的通量。体内代谢途径的测量以及 1H 成像和光谱学来表征骨骼肌遗传学、单细胞测序和 RNA seq 核心提供了外显子组。所有核心都为动物和人类研究提供服务。支持将动物模型的发现更快地转化为人类可检验的假设的能力。 UTSW NORC 为一大群不同的调查人员联合提供了一个重要的机制并集中精力进行营养和肥胖相关的研究，以加速基础科学成果的转化发现人类临床相关干预措施以改善公共卫生。