UT Southwestern NORC

UT 西南 NORC

• 批准号: 10512731
• 负责人: JAY D. HORTON
• 金额: $ 123万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10512731
• 关键词: 3-Dimensional; Address; Animal Model; Animals; Award; Behavioral; Biochemical; Blood; Blood Pressure; Body Temperature; Budgets; Cardiovascular system; Cell Separation; Cells; Cessation of life; Clinical; Collaborations; DNA Sequencing Facility; Dementia; Development; Diabetes Mellitus; Digestive System Disorders; Direct Costs; Discipline; Disease; Doctor of Philosophy; Elements; Endocrinology; Energy Metabolism; Extramural Activities; Faculty; Fatty acid glycerol esters; Funding; Gene Expression; Gene Expression Profiling; Genetic; Glucose Clamp; Goals; Heart Rate; Homeostasis; Hormones; Human; Hypertension; Image; Individual; Infrastructure; Interdisciplinary Study; Intervention; Lipids; Liver; Liver diseases; Malignant Neoplasms; Mass Spectrum Analysis; Measurement; Mentors; Metabolic; Metabolic Diseases; Metabolic Pathway; Metabolic syndrome; Metabolism; Molecular; National Institute of Diabetes and Digestive and Kidney Diseases; Obesity; Obesity associated cancer; Obesity associated disease; Organ; Paper; Pathway interactions; Peripheral; Phenotype; Prevention strategy; Public Health; Regulation; Research; Research Personnel; Research Project Grants; Research Support; Risk; Scientist; Series; Services; Signal Pathway; Skeletal Muscle; Speed; Telemetry; Time; Tissues; Training; Translating; Translations; adipocyte biology; base; clinically relevant; disability; exome sequencing; imaging modality; improved; in vivo; innovation; member; metabolic phenotype; next generation; non-alcoholic fatty liver disease; novel therapeutic intervention; nutrition; obesity treatment; post-doctoral training; programs; single cell sequencing; single-cell RNA sequencing; spectroscopic imaging; transcriptome sequencing; willingness

PROJECT SUMMARY/ABSTRACT – Overview: The overarching goal of the UTSW NORC is to enhance research efforts in nutrition and obesity by facilitating interdisciplinary interactions to speed translation of basic scientific discoveries into clinically relevant interventions in humans that improve public health. We have assembled a highly interactive and collaborative interdisciplinary team of investigators at UT Southwestern that harnesses expertise from diverse disciplines, with a goal of defining the behavioral, metabolic, genetic, and molecular mechanisms contributing to obesity and obesity-induced disease. The UTSW NORC research base consists of 158 investigators from 27 different Departments. These investigators have 230 extramurally funded nutrition/obesity-related research grants that total more than $74 million/yr in direct costs. To facilitate interdisciplinary research and the exchange of ideas, our NORC has created the following thematically related Teams: Team 1: Central Regulation of Energy Metabolism; Team 2: Adipocyte Biology and Energy Metabolism; Team 3: Obesity-induced Peripheral Organ Disease; and Team 4: Nutrition, Obesity, and Cancer. Within each team, we have integrated scientists from a wide spectrum of disciplines to comprehensively address the biochemical, metabolic, and clinical consequences of obesity and related diseases. Each Team has a mixture of senior, mid-level, and junior scientists, which will enhance the development of junior scientists and increase the likelihood of successful collaborations. The P&F program will support four new investigators/year who will also be assigned to one of the four research Teams. To support our research efforts, we have established four cores and a Clinical Element to provide state-of- the art services that exceed the capabilities, availability and/or budgets of individual NORC investigators. The Animal Phenotyping/Metabolism Core provides an extensive array of blood metabolites and hormones, 50+ metabolic cages, telemetry measurements of blood pressure, heart rate, core body temperature, and activity, multiple imaging modalities to characterize fat distribution, and hyperinsulinemic-euglycemic clamps and primary cell isolation. The Lipid Mass Spectrometry Core provides comprehensive quantification of lipids in cells, tissues, and blood. The Quantitative Metabolism and Imaging Core provides sophisticated flux measurements of metabolic pathways in vivo and 1H imaging and spectroscopy to characterize skeletal muscle and liver lipid content in humans. The Genetics, Single Cell Sequencing & RNA seq core provides exome sequencing and gene expression and analysis. All cores provide services for animal and human research, supporting the ability to translate findings more rapidly from animal models into testable hypothesis in humans. The UTSW NORC provides an important mechanism for a large group of diverse investigators to coalesce and focus their research efforts related to nutrition and obesity to accelerate translation of basic scientific discoveries into clinically relevant interventions in humans to improve public health.

项目摘要/摘要 - 概述： UTSW NORC的总体目标是通过通过 促进跨学科的互动，以加快基本科学发现转化为临床相关的 对改善公共卫生的人类干预措施。我们组装了高度互动和协作的 UT西南研究人员的跨学科团队利用潜水学科的专业知识， 以定义有助于肥胖的行为，代谢，遗传和分子机制 和肥胖引起的疾病。 UTSW NORC研究基础由来自27个不同部门的158名调查员组成。这些 研究人员拥有230个外部资助的营养/肥胖相关研究补助金，总计超过74美元 直接成本百万/年。为了促进跨学科研究和思想的交流，我们的NORC拥有 创建了以下主题相关的团队：团队1：能源代谢的中央法规；团队2： 脂肪细胞生物学和能量代谢；团队3：肥胖引起的外围器官疾病；和团队4： 营养，肥胖和癌症。在每个团队中，我们都综合了各种各样的科学家 学科全面解决肥胖和临床的生化，代谢和临床后果 相关疾病。每个团队都有高级，中级和初级科学家的混合体，这将增强 开发初级科学家并增加了成功合作的可能性。 P＆F计划将 支持四名新调查人员/年，他们还将被分配到四个研究团队之一。 为了支持我们的研究工作，我们建立了四个核心和一个临床因素，以提供最新 超出个人NORC调查人员能力，可用性和/或预算的艺术服务。这 动物表型/代谢核心提供了广泛的血液代谢产物和激素，50+ 代谢笼，血压，心率，核心体温和活动的遥测测量， 多种成像方式以表征脂肪分布，高胰岛素 - 毛囊夹具和 一级细胞分离。脂质质谱核心提供了脂质的全面量化 细胞，组织和血液。定量代谢和成像核心提供了复杂的通量 体内代谢途径的测量和1H成像和光谱法表征骨骼肌 和人类的肝脂质含量。遗传学，单细胞测序和RNA SEQ核心提供外显子组 测序和基因表达和分析。所有核心为动物和人类研究提供服务， 支持将发现从动物模型更快地转化为人类可检验的假设的能力。 UTSW NORC为大量潜水员调查员提供了重要的机制 并集中于与营养和肥胖有关的研究工作，以加速基本科学的翻译 在人类中发现与临床相关的干预措施，以改善公共卫生。