Effects of Noise Exposure Across the Lifespan on Balance and Stability in Older Adults

一生中噪声暴露对老年人平衡和稳定性的影响

基本信息

批准号：
10833752
负责人：
Natela M. Shanidze
金额：
$ 3.59万
依托单位：
VETERANS EDUCATION AND RESEARCH ASSOCIATION OF MICHIGAN
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-30 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10833752
关键词：
Acceleration Accidents Acoustics Address Affect Age Aging Anatomy Animal Experimentation Animal Model Animals Basic Science Cells Cervical Cessation of life Characteristics Clinical Cochlea Compensation Control Groups Detection Devices Diagnosis Disease Dose Elderly Electrophysiology (science)Environment Epithelium Equilibrium Exhibits Exposure to FDA approved Force of Gravity Frequencies Functional disorder Genetic Goals Head Head Movements Hearing Human Impairment Individual Injury Investigation Judgment Labyrinth Life Link Longevity Maintenance Measurement Measures Methods Modeling Morphology Motion Motor Musculoskeletal Equilibrium Neurons Noise Noise-Induced Hearing Loss Organ Outcome Participant Performance Physical shape Physiological Play Population Posture Predisposition Prevention Proprioception Rattus Recommendation Recording of previous events Reflex action Rehabilitation therapy Risk Risk Factors Role Rotation Secondary to Semicircular canal structure Sensory Source Spinal Cord Structure Symptoms System Testing Time Training Variant Vestibular Nerve Vestibular loss Vision Walking age group age related aging population body position clinical application cohort comparison control cost disability equipment acquisition experimental study fall risk falls functional improvement human old age (65+)human subject improved insight motor impairment neglect noise exposure otoconia parent grant posture instability pressure response secondary analysis senescence sound treatment strategy vestibulo-ocular reflex

项目摘要

Abstract Loss of stability and falls is a major risk factor for injury and death in older adults. Previously overlooked, lifetime noise exposure has been shown to cause damage to the vestibular periphery; although, animal models and human studies that can provide a mechanistic basis connecting noise-induced vestibular dysfunction and age-related fall risk are limited. The vestibular system plays a critical role in detection of head movements and orientation with respect to gravity and is essential for normal vision and postural control. Due to their anatomical proximity to the cochlea, the otolith organs are exposed to sound pressure and are at risk for noise overstimulation, which may contribute to vestibular dysfunction. Recent studies have linked noise overstimulation to decreased vestibular nerve activity and loss of a specialized class of irregularly firing vestibular afferents which exhibit enhanced sensitivity to acceleration. It is likely that these afferents play an important role initiating postural compensation for abrupt changes in head or body position due to their physiological characteristics and their projection to secondary vestibular neurons that project to the spinal cord. Therefore, the effects of noise may accelerate disability associated with natural aging. The goal of this supplement is to purchase equipment to measure vestibular evoked myogenic potentials (VEMP) in human participants, and thus assess changes in otolith function associated with noise exposure. The inclusion of VEMP reflects Reviewer recommendation to use vestibular-evoked myogenic potentials to directly assess how noise exposure might affect otolith function in humans and compare to outcomes in the rat. The VEMP experiments will be performed in lieu of the dynamic tilt detection experiments proposed in the parent grant. VEMP testing can be done in the same, or shorter amount of time to assess otolith function under dynamic stimulation conditions. This supplement will allow us to incorporate a well-characterized physiological assessment in human subjects to evaluate the underlying mechanisms in increased falls and fall risk due to a history of noise exposure in older adults. The susceptibility of these individuals to potentially fatal falls underscores the need for a systematic approach, that can eventually result in improved training and rehabilitation methods to be used with this population.

抽象的失去稳定性和跌倒是老年人受伤和死亡的主要危险因素。之前被忽视的，事实证明，终生接触噪音会对前庭周边造成损害；虽然，动物模型和人类研究可以提供连接噪声引起的前庭功能障碍和与年龄相关的跌倒风险有限。前庭系统在检测头部运动和相对于重力的定向对于正常视力和姿势控制至关重要。由于他们的耳石器官在解剖学上靠近耳蜗，暴露于声压下，存在噪音风险过度刺激，可能导致前庭功能障碍。最近的研究表明噪音与过度刺激导致前庭神经活动减少和特殊类别的不规则放电丧失前庭传入神经对加速度表现出增强的敏感性。这些传入神经可能发挥着对于由于头部或身体位置的突然变化而启动姿势补偿的重要作用生理特征及其对投射到脊髓的次级前庭神经元的投射。因此，噪音的影响可能会加速与自然衰老相关的残疾。此举的目标补充是购买测量人体前庭诱发肌源电位（VEMP）的设备参与者，从而评估与噪声暴露相关的耳石功能的变化。纳入 VEMP 反映了审稿人建议使用前庭诱发肌源性电位来直接评估如何噪音暴露可能会影响人类的耳石功能，并与大鼠的结果进行比较。 VEMP 将进行实验来代替父资助中提出的动态倾斜检测实验。 VEMP 测试可以在相同或更短的时间内完成，以评估动态下的耳石功能刺激条件。该补充品将使我们能够融入一种充分表征的生理学对人类受试者进行评估，以评估由于跌倒和跌倒风险增加的潜在机制老年人有噪音暴露史。这些人容易遭受致命的跌倒强调需要采取系统性方法，最终能够改进培训和针对该人群使用的康复方法。