Intersubject Synchrony in Neural and Behavioral Representations of Social Uncertainty Among Adults and Adolescents

成人和青少年社会不确定性的神经和行为表征的主体间同步性

基本信息

批准号：
10828675
负责人：
William John Mitchell
金额：
$ 3.44万
依托单位：
TEMPLE UNIV OF THE COMMONWEALTH
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-20 至 2025-09-19
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10828675
关键词：
Adolescence Adolescent Adolescent Development Adult Affective Anxiety Anxiety Disorders Applications Grants Attention Automobile Driving Behavioral Belief Characteristics Cognition Cognitive Complex Computing Methodologies Crime Data Decision Making Dedications Development Drama Emotional Emotions Evaluation Exhibits Experimental Designs Familiarity Fellowship Functional Magnetic Resonance Imaging Future Goals Guilt Human Individual Instruction Judgment Knowledge Life Cycle Stages Literature Measurement Measures Memory Mental Depression Mentorship Methods Mood Disorders Moods Neurosciences Research Outcome Participant Pattern Peer Pressure Perception Phase Population Post-Traumatic Stress Disorders Postdoctoral Fellow Predisposition Process Psyche structure Research Research Design Research Personnel Research Project Grants Risk Taking Sampling Severities Social Development Source Stimulus Stressful Event Techniques Time Training Trust Uncertainty Vulnerable Populations Work age related autism spectrum disorder clinically relevant clinically significant computational neuroscience cost emotion dysregulation expectation experience luminance multimodality neural neural circuit neural model neural recruitment neuroimaging neuromechanism novel pre-doctoral response skills social social cognition social neuroscience social situation social stressor theories

项目摘要

Project Summary Uncertainty is an often pervasive, stressful experience that arises when making judgments about others' beliefs, intentions, or emotions (i.e., ambiguous social situations). Excessive uncertainty can have pernicious effects upon memory, mood, and physical and mental outcomes. Yet, we understand little of how judgments of social certainty form over time, the neural circuitry underlying these judgments, and how these judgments meaningfully differ from non-social uncertainty sources (e.g., calculations, perceptions). Uncertainty is featured in every developmental stage but adolescents and adults differ in their appraisals of and responses to ambiguity; both social and non-social. Traditional univariate neuroimaging analyses, which compare average magnitudes of activation across broad neural regions, are unresponsive to the subtle pattern differences that characterize complex social cognition. Novel multivariate techniques, such as intersubject correlations (ISC), applied to dynamic, feature-rich, and ecologically-valid sources of social ambiguity are crucial for understanding fundamental aspects of social cognition but have not yet been applied to answer these important questions. F99 Phase: My proposed pre-doctoral project uses a novel study design in which adult participants continuously rate their certainty of a given social (e.g., a character's innocence or guilt) and non-social (e.g., frame luminance) outcome while observing long-form narrative video stimuli (i.e., 45 min crime drama) during fMRI. This yields a continuous time course of concurrently-recorded neural and behavioral data which can be analyzed via ISC to determine the neural circuitry commonly implicated in uncertainty judgment formation among normative adult populations. Interdomain neural-behavioral synchrony can underscore how social and non-social certainty judgment formation mechanisms differ. Defining normative adult neural uncertainty responses provides a crucial comparison to vulnerable populations with pronounced uncertainty responses, including autism spectrum, anxiety, and mood disorders. Training during this phase includes instruction in computational methods relevant to the neuroscience of social decision-making and neurodevelopmental theory to prepare for the K00 Phase. K00 Phase: This phase extends my pre-doctoral research by applying the F99 Phase study design to adolescent populations. This approach could identify whether adults and adolescents are generally relying on distinct or similar neural circuitry to assess the same stimuli and inform subjective indicators of uncertainty (i.e., behavioral ratings). Adolescence is a period marked by intense attention towards social others. The presence of ambiguous social stressors during this period predicts susceptibility to and severity of anxiety and depression into adulthood. Thus, how social uncertainty is processed has notable implications for researchers working at any later developmental stage. The training plan in this phase of the proposal will focus on developing expertise in the developmental social neuroscience literature, computational methods that can be applied to developmental social neuroscience research, and mentorship skills to establish a diverse, inclusive independent research lab.

项目概要不确定性是一种普遍存在的、有压力的体验，在对他人的信念做出判断时会出现，意图或情感（即模糊的社交情境）。过度的不确定性可能会产生有害的影响取决于记忆、情绪以及身心结果。然而，我们对社会判断如何知之甚少。随着时间的推移，确定性会形成，这些判断背后的神经回路，以及这些判断如何有意义不同于非社会不确定性来源（例如计算、感知）。一切都存在不确定性发展阶段，但青少年和成人对模糊性的评价和反应有所不同；两个都社会性和非社会性。传统的单变量神经影像分析，比较了跨广泛神经区域的激活，对表征的微妙模式差异没有反应复杂的社会认知。新颖的多变量技术，例如主体间相关性（ISC），应用于动态的、特征丰富的、生态上有效的社会模糊性来源对于理解至关重要社会认知的基本方面，但尚未应用于回答这些重要问题。 F99阶段：我提出的博士前项目采用了一种新颖的研究设计，其中成人参与者不断评价他们对特定社交（例如，角色的清白或有罪）和非社交（例如，帧亮度）的确定性在功能磁共振成像期间观察长篇叙事视频刺激（即 45 分钟的犯罪剧）时的结果。这产生了一个同时记录的神经和行为数据的连续时间过程，可以通过 ISC 进行分析确定通常与规范成人不确定性判断形成有关的神经回路人口。域间神经行为同步可以强调社会和非社会确定性判断形成机制不同。定义规范的成人神经不确定性反应提供了至关重要的与具有明显不确定性反应的弱势群体（包括自闭症谱系）进行比较，焦虑和情绪障碍。此阶段的培训包括相关计算方法的指导社会决策的神经科学和神经发育理论，为 K00 阶段做准备。 K00 阶段：此阶段通过将 F99 阶段研究设计应用于青少年来扩展我的博士前研究人口。这种方法可以确定成年人和青少年是否普遍依赖不同或类似的神经回路来评估相同的刺激并告知不确定性的主观指标（即行为评级）。青春期是一个对社会他人高度关注的时期。暧昧的存在这一时期的社会压力源预示着成年后焦虑和抑郁的易感性和严重程度。因此，如何处理社会不确定性对于以后的研究人员具有显着的影响。发育阶段。该提案此阶段的培训计划将侧重于培养以下领域的专业知识：发展社会神经科学文献，可应用于发展的计算方法社会神经科学研究和指导技能，以建立一个多元化、包容性的独立研究实验室。