22nd Liver Sinusoid Meeting

第22次肝正弦波会议

• 批准号: 10805816
• 负责人: Natalia Nieto
• 金额: $ 2万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-20 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10805816
• 关键词: Acute; Alcoholic Liver Diseases; Alcohols; Anatomy; Area; Award; B-Lymphocytes; Basic Science; Biology; Biomedical Engineering; Cell Communication; Cell physiology; Cells; Cellular biology; Chicago; Clinical Investigator; Clinical Research; Collaborations; Communities; Complex; Country; Data; Development; Developmental Biology; Disabled Persons; Discipline; Discontinuous Capillary; Disease; Endothelial Cells; Environment; Event; Fibrosis; Functional disorder; Genetic; Goals; Health; Hepatic; Hepatic Stellate Cell; Hepatocyte; Hepatology; Illinois; Individual; Inflammation; International; Intoxication; Knowledge; Kupffer Cells; Liver; Liver Fibrosis; Liver Regeneration; Liver diseases; Macrophage; Medicine; Methodology; Microcirculation; Modality; Molecular; Nanotechnology; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Alcohol Abuse and Alcoholism; Natural Killer Cells; Nature; Oncology; Operative Surgical Procedures; Oral; Organoids; Participant; Pathogenesis; Pharmaceutical Preparations; Physicians; Physiology; Population; Postdoctoral Fellow; Primary carcinoma of the liver cells; Regulation; Request for Applications; Research; Research Personnel; Resolution; Resource Sharing; Role; Science; Scientist; Signal Transduction; Societies; Steatohepatitis; T-Lymphocyte; Therapeutic; Tissues; Translational Research; Travel; Universities; Woman; cell type; chronic liver disease; college; ethnic minority; frontier; hepatic sinusoid; immunoregulation; improved; innovation; interest; lectures; meetings; multidisciplinary; multiple omics; non-alcoholic fatty liver disease; novel; novel diagnostics; novel therapeutics; posters; pre-doctoral; racial minority; recruit; response; social; symposium; synergism; tool; translational scientist

ABSTRACT This R13 application requests support for the 22nd Liver Sinusoid Meeting from the International Society for Hepatic Sinusoidal Research (ISCHS), to be on April 24-26, 2024, in the College of Medicine at the University of Illinois at Chicago. The application requests support from NIAAA and NIDDK for the participation of trainees and non-funded early-stage investigators (ESI). The goal of the Liver Sinusoid Meeting is to bring together an international group of multidisciplinary scientists, including established and new investigators, pre- and post- doctoral trainees, who are interested in the common questions: 1) how hepatic sinusoidal liver cells and their crosstalk, contribute to the pathogenesis and resolution of alcohol-associated liver disease (AALD), non- alcoholic fatty liver disease (NAFLD), fibrosis, stimulation or suppression of liver regeneration, regulation of liver microcirculation, and hepatocellular carcinoma (HCC) onset and progression; and 2) how new knowledge from emerging tools applicable to all areas of liver research, such as multiomics, matrisomics, bioengineered liver tissue, organoids, nanotechnologies, and immunomodulation can be used to improve treatments of liver disease. Participants at the meeting will present cutting-edge, high-quality research, which begins to identify novel molecular and cellular interactions within the liver sinusoid. There are surprising gaps in our understanding of this basic unit of functional activity in the liver; advances in hepatic sinusoidal cell biology are critical to understanding the cellular basis of AALD, acute, and chronic liver disease. The ISCHS represents the only international organization, which gathers leading investigators in liver biology and hepatocellular cross talk from around the world. This meeting will facilitate and promote: 1) international collaborations among different countries with populations differing in their genetics and social backgrounds who suffer from AALD, acute, and chronic liver disease; 2) resource sharing among international investigators, generating synergy and unique ideas; and 3) interaction of trainees at the international level. Taken together, the unique environment of the Liver Sinusoid Meeting is an ideal format for cutting-edge interactions on the potential implications of their research into the pathogenesis of AALD, acute, and chronic liver disease, helping to synergize research that will fill these gaps and advance the frontier of research in liver disease, and development of preventative and therapeutic treatments.

抽象的 此 R13 申请请求国际肝病学会对第 22 届肝正弦波会议的支持 肝正弦研究 (ISCHS)，将于 2024 年 4 月 24 日至 26 日在大学医学院举行 伊利诺伊州芝加哥。该申请请求NIAAA和NIDDK支持学员参与 和非资助的早期研究人员（ESI）。肝正弦波会议的目标是汇集 由多学科科学家组成的国际小组，包括已建立的和新的研究人员、研究前和研究后 博士生们，感兴趣的常见问题有：1）肝窦肝细胞及其 串扰，有助于酒精相关性肝病（AALD）的发病机制和解决，非 酒精性脂肪肝病 (NAFLD)、纤维化、刺激或抑制肝再生、调节 肝脏微循环和肝细胞癌（HCC）的发病和进展； 2）新知识如何 来自适用于肝脏研究所有领域的新兴工具，例如多组学、基质组学、生物工程 肝组织、类器官、纳米技术和免疫调节可用于改善肝脏治疗 疾病。会议参与者将介绍尖端的、高质量的研究，这些研究开始确定 肝窦内新颖的分子和细胞相互作用。我们的差距令人惊讶 了解肝脏功能活动的基本单位；肝窦细胞生物学的进展 对于了解 AALD、急性和慢性肝病的细胞基础至关重要。 ISCHS 代表 唯一聚集肝脏生物学和肝细胞交叉领域顶尖研究人员的国际组织 来自世界各地的谈话。本次会议将促进和促进：1）国际合作 不同国家的人口遗传和社会背景不同，患有 AALD， 急性和慢性肝病； 2）国际研究者资源共享，产生协同效应 和独特的想法； 3) 学员在国际层面的互动。综合起来，独一无二 肝脏正弦波会议的环境是潜在的前沿互动的理想形式 他们的研究对 AALD、急性和慢性肝病的发病机制的影响，有助于 协同研究将填补这些空白并推进肝病研究的前沿，以及 预防和治疗方法的发展。