Improving Vaccine Delivery in Hospitalized Children

改善住院儿童的疫苗接种

• 批准号: 10806029
• 负责人: Mersine Alexis Bryan
• 金额: $ 15.56万
• 依托单位: SEATTLE CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-21 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10806029
• 关键词: Acceleration; Address; Applications Grants; Award; COVID-19 pandemic; Child; Childhood; Clinical; Clinical Trials; Clinical Trials Design; Communication; Communication Research; Competence; Consolidated Framework for Implementation Research; Coupled; Data; Dedications; Disease; Disease Outbreaks; Educational workshop; Electronic Health Record; Eligibility Determination; Ensure; Evaluation; Evidence based intervention; Evidence based practice; Future; Goals; Healthcare; Hospitalists; Hospitalization; Hospitalized Child; Hospitals; Immunization; Information Systems; Inpatients; Intervention; Interview; Maps; Measles; Mentors; Mentorship; Methods; Morbidity - disease rate; National Institute of Child Health and Human Development; Nurses; Parents; Pediatric Hospitals; Pediatric Research; Persons; Pharmacists; Phase; Physicians; Population; Primary Care; Public Health; Registries; Research; Research Personnel; Risk; Sampling; Site; Surveys; Technology; Testing; Training; Translating; Translations; United States Dept. of Health and Human Services; Vaccinated; Vaccination; Vaccines; Work; acceptability and feasibility; analytical method; care outcomes; career; career development; clinical practice; contextual factors; design; effectiveness-implementation randomized trial; health communication; health information technology; high risk; implementation outcomes; implementation science; implementation strategy; improved; informant; innovative technologies; intervention refinement; mortality; multidisciplinary; pilot test; point of care; population based; prototype; public health priorities; research and development; skills; success; therapy design; therapy development; transmission process; usability; user centered design; vaccine access; vaccine delivery; vaccine hesitancy

PROJECT SUMMARY/ABSTRACT: This proposal describes a five-year research and career development training plan that will prepare Dr. Bryan to achieve her career goal of becoming an independent pediatric clinical researcher focused on improving healthcare outcomes for hospitalized children by accelerating the translation of evidence-based interventions into clinical practice using innovative technologies. This proposal is focused on improving vaccination rates in hospitalized children, a high priority population and issue for NICHD. Up to 74% of hospitalized children are missing ≥1 non-influenza vaccines. Currently, hospitalization is a missed opportunity to vaccinate as ~2% of hospitalized children receive any non-influenza vaccines. Integrating implementation science and user- centered design methods, Dr. Bryan’s project goal is to design and test a user-centered intervention that optimizes the integration of Immunization Information Systems data into hospital Electronic Health Records to improve vaccine delivery for hospitalized children. In Aim 1, Dr. Bryan will conduct a mixed methods study of a local and national sample of pediatric hospitalists, nurses and pharmacists to identify determinants and contextual factors for an intervention to identify undervaccinated children and offer needed vaccines using the Consolidated Framework for Implementation Research (CFIR). In Aim 2, she will engage with parents, nurses, pharmacists, physicians, and health information technology experts through workshops and rapid cycle prototyping to develop a prototype for a user-centered intervention that meets the user needs and context identified in Aim 1. She will conduct usability testing and expert evaluation to ensure the design meets the requirements prior to the intervention build and workflow integration. In Aim 3, Dr. Bryan will deploy and pilot test the designed intervention to assess feasibility and acceptability for clinicians and parents. This pilot test will inform a future multicenter cluster-randomized effectiveness-implementation trial to improve vaccine delivery in hospitalized children. To complete this research, Dr. Bryan will develop new competencies in: 1) implementation science, 2) user-centered design methods, and 3) technology-based intervention design. To prepare for the future clinical trial to test the developed intervention, she will also develop skills in clinical trials design and analytic methods for vaccine communication during the award period. Dr. Bryan has assembled a multidisciplinary mentorship team with expertise in vaccine communication research, implementation science, user-centered design, and technology-based intervention design. Her mentors are dedicated to ensuring the success of this project and her career development into an independent researcher. By accomplishing the aims in this proposal, Dr. Bryan will address key gaps in our ability to increase vaccination rates in hospitalized children. Ultimately, this proposal will provide Dr. Bryan the skills she needs in implementation science, user- centered design, technology-based intervention design, clinical trials design and analytic methods for health communication for a research career dedicated to improving healthcare outcomes in hospitalized children.

项目概要/摘要： 该提案描述了一项为期五年的研究和职业发展培训计划，该计划将为布莱恩博士做好准备 实现成为一名独立儿科临床研究员的职业目标，专注于提高 通过加速循证干预措施的转化，改善住院儿童的医疗保健结果 该提案的重点是提高疫苗接种率。 住院儿童是 NICHD 的重点人群和问题。 高达 74% 的住院儿童属于此类。 目前，约有 2% 的人错过了 1 种非流感疫苗住院治疗的机会。 住院儿童接受任何非流感疫苗。 以用户为中心的设计方法，布莱恩博士的项目目标是设计和测试以用户为中心的干预措施 优化免疫信息系统数据与医院电子健康记录的集成，以 改善住院儿童的疫苗接种 在目标 1 中，布莱恩博士将对一项混合方法进行研究。 当地和国家的儿科住院医师、护士和药剂师样本，以确定决定因素和 采取干预措施的背景因素，以识别未接种疫苗的儿童并使用以下方法提供所需的疫苗： 在目标 2 中，她将与家长、护士、 通过研讨会和快速周期，药剂师、医生和健康信息技术专家 原型设计，开发满足用户需求和环境的以用户为中心的干预原型 目标 1 中确定的。她将进行可用性测试和专家评估，以确保设计满足 在目标 3 中，Bryan 博士将部署和试点干预措施构建和工作流程集成之前的要求。 测试设计的干预措施，以评估牧师和家长的可行性和可接受性。 将为未来的多中心集群随机有效性实施试验提供信息，以改进疫苗 为了完成这项研究，布莱恩博士将开发以下方面的新能力：1) 实施科学，2）以用户为中心的设计方法，3）基于技术的干预设计。 为未来的临床试验做好准备，以测试所开发的干预措施，她还将培养临床试验技能 布莱恩博士在获奖期间收集了疫苗通讯的设计和分析方法。 多学科指导团队在疫苗传播研究、科学实施、 她的导师致力于确保以用户为中心的设计和基于技术的干预设计。 该项目的成功以及她成为一名独立研究员的职业发展。 为了实现该提案的目标，布莱恩博士将解决我们提高住院疫苗接种率的能力方面的关键差距 最终，该提案将为布莱恩博士提供她在实施科学、用户方面所需的技能。 以健康为中心的设计、基于技术的干预设计、临床试验设计和分析方法 致力于改善住院儿童医疗保健结果的研究事业的沟通。