VERITY: Value and Evidence in Rheumatology using bioInformaTics, and advanced analYtics

VERITY：使用生物信息学和高级分析在风湿病学中的价值和证据

基本信息

批准号：
10705645
负责人：
Daniel Hal Solomon
金额：
$ 89.11万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-15 至 2027-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10705645
关键词：
Adult Behavioral Bioinformatics COVID-19 pandemic Case Study Childhood Clinical Clinical Investigator Clinical Research Communities Conduct Clinical Trials Data Economics Ensure Faculty Future Grant Hospitals Intervention Journals Learning Machine Learning Mentors Mentorship Methodology Methods Musculoskeletal Musculoskeletal Diseases National Institute of Arthritis, and Musculoskeletal, and Skin Diseases Paper Patients Perception Persons Phenotype Productivity Publications Research Research Personnel Research Project Grants Research Support Research Training Resources Rheumatism Rheumatology Services Stream Training Underrepresented Minority Woman Work advanced analytics behavioral economics bioinformatics resource cohort data integration design ethnic minority improved outcome minority investigator next generation phenotypic data programs racial minority recruit research study rheumatologist service utilization skills social health determinants success theories tool treatment effect

项目摘要

PROJECT SUMMARY The overarching long-term aims of VERITY are: 1) to develop state-of-the-art methods for clinical research in rheumatology and musculoskeletal diseases that are relevant for the Research Community, 2) to deliver methodologic and bioinformatic assistance to the Research Community, and 3) to train the Research Community in state-of-the-art methods through courses, seminars, and mentoring. During the last cycle, VERITY recruited a large and growing Research Community of rheumatic and MSK disease investigators who participate in courses, mentoring, and utilize the services of the three VERITY Cores. The Overall Section of the application describes: the progress and future directions for VERITY’s burgeoning Research Community; how VERITY has developed and delivered courses to respond to the Research Community’s needs, especially during the COVID pandemic; plans for future courses and mentoring of trainees and junior faculty; and the services offered and organization of the Methodology Core and the Bioinformatics Core. During the previous cycle, VERITY developed a diverse Research Community that has included many junior faculty and trainees, a good number of pediatric rheumatologists, and an increasing group of MSK investigators. These researchers represent the tremendous diversity of clinical investigators engaged with NIAMS-focused topics. In addition, the large group of investigators helps provide the Cores with a steady stream of activity and resources. During the prior cycle of the BWH CCCR, VERITY helped produce 160 original articles already cited 1,287 times. These original articles appeared in high impact journals. The VERITY Research Community has been successful with 109 grant submissions during the last 4+ years, tabulating a total of $40,073,225 in annual direct research revenues. The three Cores have been extremely productive and learned much about working effectively with the Research Community. The proposed aims build on the prior successes with: an enhanced Enrichment Program increasing the focus on URiM researchers in rheumatology; a Methodology Core that ensures methodologic rigor while incorporating behavioral theory and economics into studies focused on racial and ethnic minorities; and a Bioinformatics Core that provides bioinformatic support to better phenotype patient cohorts, allowing for studies of social determinants of health.

项目概要 VERITY 的总体长期目标是： 1) 开发最先进的临床研究方法与研究界相关的风湿病和肌肉骨骼疾病，2) 提供为研究界提供方法学和生物信息学援助，以及 3) 培训研究人员通过课程、研讨会和指导，以最先进的方式建立社区。 VERITY 招募了一个由风湿病和 MSK 疾病研究人员组成的大型且不断壮大的研究社区，他们参与课程、指导并利用三个 VERITY 核心的服务。该应用程序描述了： VERITY 蓬勃发展的研究社区的进展和未来方向； VERITY 如何开发和提供课程来满足研究界的需求，特别是在新冠疫情期间，未来的课程以及对学员和初级教师的指导；方法学核心和生物信息学核心提供的服务和组织。 VERITY 开发了一个多元化的研究社区，其中包括许多初级教师和实习生，大量的儿科风湿病专家，以及越来越多的 MSK 斯隆研究人员。此外，庞大的调查员团队有助于为核心提供源源不断的活动和资源。在 BWH CCCR 的上一周期中，VERITY 帮助制作了 160 篇原创文章，已被引用 1,287 篇这些原创文章出现在 VERITY 研究社区的高影响力期刊上。在过去 4 年多的时间里，已成功提交 109 笔赠款，总计金额为 40,073,225 美元三个核心的年度直接研究收入非常高产并且学到了很多东西。关于与研究界有效合作的建议目标建立在先前的成功基础上：强化的强化计划增加了对 URiM 研究人员在风湿病学方法学方面的关注；确保方法严谨性的核心，同时将行为理论和经济学纳入研究专注于少数族裔；以及生物信息学核心，为更好地提供生物信息支持表型患者队列，允许研究健康的社会决定因素。

项目成果

期刊论文数量（69）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Administrative Data Use in National Registry Efforts: Blessing or Curse?

国家登记工作中的行政数据使用：祝福还是诅咒？

DOI：
发表时间：
2022-10-19
期刊：
影响因子：
0
作者：
Bedard, Nicholas A;Katz, Jeffrey N;Losina, Elena;Opare;Kopp, Paul T
通讯作者：
Kopp, Paul T

Patterns in the Sequential Treatment of Patients With Rheumatoid Arthritis Starting a Biologic or Targeted Synthetic Disease-Modifying Antirheumatic Drug: 10-Year Experience From a US-Based Registry.

类风湿关节炎患者开始使用生物或靶向合成疾病缓解抗风湿药物的序贯治疗模式：来自美国登记处的 10 年经验。

DOI：
发表时间：
2024-01
期刊：
影响因子：
3.4
作者：
Matsson, Anton;Solomon, Daniel H;Crabtree, Margaux M;Harrison, Ryan W;Litman, Heather J;Johansson, Fredrik D
通讯作者：
Johansson, Fredrik D

Assessing clusters of comorbidities in rheumatoid arthritis: a machine learning approach.

评估类风湿关节炎的一系列合并症：一种机器学习方法。

DOI：
发表时间：
2023-11-22
期刊：
影响因子：
4.9
作者：
Solomon, Daniel H;Guan, Hongshu;Johansson, Fredrik D;Santacroce, Leah;Malley, Wendi;Guo, Lin;Litman, Heather
通讯作者：
Litman, Heather

The influence of meniscal pathology in the incidence of knee osteoarthritis: a review.

半月板病理学对膝骨关节炎发病率的影响：综述。